“…Currently, the determinants of relationship between asymptomatic PAD (as characterized by ABI values <0.9 in generally healthy subjects without claudication or other related symptoms) and MetS as the accelerators of subclinical atherosclerosis in general disease-free population is unclear. Although solid evidence suggests central obesity as one of the defining components of MetS to be a better correlate of PAD rather than general obesity [10,11], conflicting reports in the literature have found different types of negative [12], positive [13], or non-associations [3] between obesity and PAD. Therefore, despite the strongly positive associations of both asymptomatic and symptomatic PADs with MetS, the main derivers behind this relationship are still very much debated.…”