Relationship of obsessive-compulsive symptoms to clinical variables and cognitive functions in individuals at ultra high risk for psychosis

Soyata, Ahmet Zihni; Akışık, Selin; İnhanlı, Damla; Noyan, Handan; Üçok, Alp

doi:10.1016/j.psychres.2018.01.004

Cited by 16 publications

(12 citation statements)

References 39 publications

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“…In fact, a categorical approach might not be appropriate to capture such dual relationship of PS impairment along a severity continuum of OC dimension. The finding of a direct association between severe OCS and PS scores (the "obsessive paradox") is in line with previous studies, which suggested a positive effect of comorbid OCS on specific cognitive functions (especially executive functions and working memory) either in patients with schizophrenia (Borkowska et al, 2003;Kontis et al, 2016;Lee et al, 2009) or in individuals with at-risk mental states for psychosis (Soyata et al, 2018;Zink et al, 2014).…”

Section: Discussionsupporting

confidence: 91%

“…PS impairment is supposed to be a core feature in schizophrenia (Dickinson et al, 2007;Knowles et al, 2010;Ojeda et al, 2012), and it is also present either in individuals at high risk of schizophrenia (Chan et al, 2018;Niendam et al, 2007;Soyata et al, 2018) or in unaffected relatives of schizophrenia patients (Wang et al, 2007). PS appears to underlie higher cognitive processes, such as working memory and executive functions (Ojeda et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

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The “Obsessive Paradox”

Tonna¹,

Ottoni

Pellegrini

et al. 2019

J Nerv Ment Dis

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The objective of the study was to investigate the relationship between cognitive functions and obsessive-compulsive dimension in schizophrenia and a possible moderating effect of schizophrenia symptom dimensions on this association. Sixty-one schizophrenia patients were administered the Positive and Negative Syndrome Scale, the Yale-Brown Obsessive-Compulsive Scale (YBOCS), and the Matrics Consensus Cognitive Battery. A U-shaped curve described a gradual transition from an inverse association to a positive relationship between YBOCS and processing speed scores, along a severity gradient of obsessive dimension. This effect ("the obsessive paradox") was not moderated by other symptom dimensions. The present study suggests that severe obsessive-compulsive symptoms may participate to counterbalance processing speed impairment independently from other symptom dimensions. These results highlight the complexity of the relationship between cognitive and obsessive dimensions in schizophrenia.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

The “Obsessive Paradox”

Tonna¹,

Ottoni

Pellegrini

et al. 2019

J Nerv Ment Dis

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“…In a longitudinal study of CHR individuals, Fontenelle et al reported that, while remitted OCD did not increase the risk of conversion to syndromal psychosis, incident comorbid OCD did increase the risk of conversion to mood disorders with psychotic features or psychotic disorders not otherwise specified (Fontenelle et al, 2011). Moreover, subthreshold positive symptoms of psychosis have been shown to be longer standing in CHR individuals who also report OCS (Soyata, Akisik, Inhanli, Noyan, & Ucok, 2018), further supporting a relationship between these symptom categories.…”

Section: Introductionmentioning

confidence: 93%

Thematic content of obsessive and compulsive symptoms and conversion to psychosis in a clinical high‐risk cohort

Kennedy

Brucato

Lundgren

et al. 2020

Early Intervention Psych

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Aim We sought to explore the complex phenomenological overlap between obsessive and compulsive symptoms (OCS), and attenuated positive symptoms among 156 young people at clinical high‐risk (CHR) for psychosis. Methods In order to explore the hypothesis that OCS of an implausible nature might optimally predict future transition to syndromal psychosis, ideas associated with obsessive and compulsive experiences elicited by clinical measures were thematically categorized as “plausible” or “implausible.” Results While OCS were found to be common in our CHR sample, we did not find that implausible OCS themes were predictive of conversion. Conclusion Given the absence of qualitative differences between OCS and early psychotic symptoms, we propose that clinicians encountering adolescent or young adult patients with new‐onset OCD or OCS in the past year should monitor such symptoms for a minimum of 2 years to assess for the possible emergence of psychosis.

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“…The individuals were defined as with UHR if they met the criteria of at least one of the following conditions: (a) Brief limited intermittent psychotic symptoms (BLIPS); (b) Attenuated psychotic symptoms and (c) Family risk with functional decline. These criteria were also used in our previous studies (Soyata, Akisik, Inhanli, Noyan, & Ucok, 2018;Ucok et al, 2013). BLIPS and attenuated symptom groups were operationally defined using the Brief Psychiatric Rating Scale-Expanded (BPRS-E; Ventura, Green, Shaner, & Liberman, 1993).…”

Section: Participantsmentioning

confidence: 99%

Reliability and validity of the Turkish version of comprehensive assessment of at risk mental states

Yokuşoğlu

Ercis

Çağlar

et al. 2020

Early Intervention Psych

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Aims: To perform the validation of the Comprehensive Assessment at Risk Mental State (CAARMS) in Turkish.Methods: Sixty-five volunteers (15-24 years) were enrolled in this study. Concurrent validity was performed with Spearman's Correlation Test using Brief Psychiatric Rating Scale (BPRS). Median scores of the groups were compared using Mann-Whitney U Test. Interrater reliability was assessed by intragroup correlation coefficient method. Internal consistency was studied by the calculation of Cronbach Alfa Coefficient.Results: The correlation of the severity scores of the CAARMS with unusual thought content, suspiciousness, hallucinations and conceptual disorganization items of the BPRS showed that the concurrent validity was good. ROC analysis revealed that CAARMS could discriminate between individuals with UHR and healthy volunteers well. We found a good correlation between the raters. Internal consistency was at very high level. Conclusion:Analyses of concurrent validity, criterion validity, interrater reliability and internal consistency indicate that the Turkish version is valid and reliable.

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Relationship of obsessive-compulsive symptoms to clinical variables and cognitive functions in individuals at ultra high risk for psychosis

Cited by 16 publications

References 39 publications

The “Obsessive Paradox”

The “Obsessive Paradox”

Thematic content of obsessive and compulsive symptoms and conversion to psychosis in a clinical high‐risk cohort

Reliability and validity of the Turkish version of comprehensive assessment of at risk mental states

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