2001
DOI: 10.1093/humrep/16.9.1814
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Relationship of ovarian stimulation response with vascular endothelial growth factor and degree of granulosa cell apoptosis

Abstract: Our findings showed that in patients with decreased ovarian response to controlled ovarian hyperstimulation, follicular fluid VEGF concentration is elevated, the concentration from granulosa cells culture supernatant is decreased and the percentage of apoptotic granulosa cells is increased, while opposite findings occurred in patients with normal or hyper-responses.

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Cited by 34 publications
(12 citation statements)
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“…A possible hypothesis [33] for this finding is that granulosa cells exposed to different oxygen conditions in vitro may suffer hypoxia and stimulate VEGF production [19]. In contrast, high VEGF levels produced by granulosa cells in culture are detected in patients with elevated plasma estradiol concentrations, with a larger number of follicles and retrieved oocytes and higher fertilization and pregnancy rates [34,35].…”
Section: Discussionmentioning
confidence: 99%
“…A possible hypothesis [33] for this finding is that granulosa cells exposed to different oxygen conditions in vitro may suffer hypoxia and stimulate VEGF production [19]. In contrast, high VEGF levels produced by granulosa cells in culture are detected in patients with elevated plasma estradiol concentrations, with a larger number of follicles and retrieved oocytes and higher fertilization and pregnancy rates [34,35].…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, in a previous report [21], we have demonstrated that the concentration of cytokines in follicular fluid does not correlate with the concentration in the supernatant of granulosa cell cultures. We found that the concentrations of VEGF in follicular fluid (FF) and in the supernatant of GC cultures were inversely proportional.…”
Section: Discussionmentioning
confidence: 58%
“…In summary, we conclude that the low response to gonadotropin stimulation as seen in hyporesponders, is likely the result of decreased angiogenesis in the gonad, and specifically in the perifollicular areas, resulting in an increased granulosa cell apoptosis and decreased production of IL-1β and VEGF [17,21]. The concentration of macrophages in hyporesponders is increased within the follicular aspirates, primarily in order to eliminate through phagocytosis the increased apoptotic bodies among the granulosa cells.…”
Section: Discussionmentioning
confidence: 84%
“…The apoptosis rate in mural cells has been proposed to be a predictor of ovarian reserves in women undergoing in vitro fertilization (during natural or gonadotropin-stimulated cycles), and high levels of apoptosis were evident in patients with low response, advanced age, and endometriosis (13)(14)(15)(16)(17).…”
mentioning
confidence: 99%