Relationship of paternal age with outcome of percutaneous epididymal sperm aspiration–intracytoplasmic sperm injection, in cases of congenital bilateral absence of the vas deferens

Elhanbly, Samir; Elsaied, Moustafa A.; Fawzy, Mohamed; El-Refaeey, A.; Mostafa, Taymour

doi:10.1016/j.fertnstert.2015.06.020

Cited by 15 publications

(8 citation statements)

References 36 publications

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“…Our study found that male age did not influence fertilization, embryo cleavage, or pregnancy rate, which is consistent with previous research 45 . However, another study reported significant correlations between male age and pregnancy and birth rates 47 .…”

Section: Discussionsupporting

confidence: 93%

Factors Influencing Success Rate of Intracytoplasmic Sperm Injection with Azoospermic Male Patients

Rehnitz

Rösner

Harsch

et al. 2020

Geburtshilfe Frauenheilkd

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Introduction Azoospermia affects about 1% of men, of whom up to 15% inquire about infertility treatment. Information about predictive factors for these couples is very limited. Patients, Materials and Methods We performed a retrospective analysis of the clinical records of 118 cycles of intracytoplasmic sperm injection treatment after testicular sperm extraction for male azoospermia carried out between January 2008 and October 2015. Of those, 66 were first, 35 second, and 17 third cycles. Statistical significance was set at p < 0.05. Predictive factors for successful pregnancy were evaluated and included male/female age, male/female body mass index, male/female nicotine use, and histological results of testes biopsies. Results Embryo quality and the number of embryos transferred were positively associated with pregnancy success (p = 0.003). Males whose partners conceived had a significantly lower body mass index than those whose partners did not conceive (p = 0.023). Neither female weight nor age nor smoking status of the male or female were significant factors. In cases with tubular atrophy ≥ SIGG grade 4 the chance of pregnancy was poor, irrespective of the existence of mature sperm and the number of cycles performed. Conclusion Overweight male patients should be advised about weight reduction prior to treatment, and counseling about success rates should include histological and sperm-positive biopsy results.

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Section: Discussionsupporting

confidence: 93%

Factors Influencing Success Rate of Intracytoplasmic Sperm Injection with Azoospermic Male Patients

Rehnitz

Rösner

Harsch

et al. 2020

Geburtshilfe Frauenheilkd

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“…By analyzing 85 CBAVD patients who had undergone PESA-ICSL, Elhanbly et al demonstrated that paternal age was negatively correlated with sperm count, motility, vitality, and normal sperm morphology. They estimated a reduction in the number of retrieved-sperm of 0.53 million per 10 years (Elhanbly et al, 2015). In addition to age and CBAVD, a variety of metabolic (e.g.…”

Section: Discussionmentioning

confidence: 99%

Report of a Father With Congenital Bilateral Absence of the Vas Deferens Fathering a Child With Beare–Stevenson Syndrome

Ferreira

Dantas

2020

Front. Genet.

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Background: Apert, Pfeiffer, and Crouzon syndromes are autosomal dominant diseases characterized by craniosynostosis. They are paternal age effect disorders. The association between paternal age and Beare-Stevenson syndrome (BSS), a very rare and severe craniosynostosis, is uncertain. Gain-of-function mutations in FGFR2 become progressively enriched in testes as men age and were shown to cause these syndromes. Case report: Here, we describe a child affected with BSS, whose father was 36 years old and had congenital bilateral absence of the vas deferens (CBAVD). The child was heterozygous for the pathogenic FGFR2 variant c.1124A > G p.Tyr375Cys. By reviewing the literature, we found that BSS fathers are older than BSS mothers (mean age in years: 39 ± 10 vs 30 ± 6, p = 0.006). Male age greater than 34 years and CBAVD are both factors associated with poor spermogram parameters, which may represent an additional selective pressure to sperm carrying FGFR2 gain-of-function mutations. Conclusion: These findings are consistent with the hypothesis that BSS is a paternalorigin genetic disorder. Further experimental studies would be needed to confirm this hypothesis.

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“…From the perspective of andrology, the primary treatment purpose of CBAVD is to solve the problem with the goal of enabling the conception of genetic offspring, and CBAVD is often discovered and diagnosed because of long-term male infertility. With the development of sperm extraction technology and ART, CBAVD patients can achieve fertility with the aforementioned two technologies (Elhanbly et al, 2015;Fang et al, 2020;Jixiang et al, 2021). For CBAVD patients, the first step of ART methods, such as intracytoplasmic sperm injection (ICSI), is the procedure for obtaining sperm.…”

Section: Treatment and Art Outcomesmentioning

confidence: 99%

Congenital Bilateral Absence of the Vas Deferens

Cai

2022

Front. Genet.

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Congenital bilateral absence of the vas deferens (CBAVD) is clinically characterized by the absence of the bilateral vas deferens; the main clinical manifestation is infertility, accounting for 1–2% of male infertility cases. CBAVD may be accompanied by congenital abnormalities in the urogenital system and cystic fibrosis (CF)-related clinical manifestations. CBAVD can develop as a mild manifestation of CF or can be isolated. The main pathogenic mechanism of CBAVD is gene mutation, and CBAVD and CF have a common genetic mutation background. CFTR mutation is the main pathogenic cause of CBAVD and CF, and ADGRG2 mutation is the second most common cause. Although lack of the vas deferens in CBAVD patients causes infertility due to the inability to release sperm, the testes of CBAVD patients have spermatogenic function. Therefore, CBAVD patients can achieve fertility through sperm retrieval surgery and assisted reproductive technology (ART). However, gene mutations in CBAVD patients can have an impact on the ART outcome, and there is a risk of passing on gene mutations to offspring. For CBAVD patients and their spouses, performing genetic counseling (which currently refers mainly to CFTR mutation screening) helps to reduce the risks of genetic mutations being passed on to offspring and of offspring having CF with concomitant CBAVD.

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Relationship of paternal age with outcome of percutaneous epididymal sperm aspiration–intracytoplasmic sperm injection, in cases of congenital bilateral absence of the vas deferens

Cited by 15 publications

References 36 publications

Factors Influencing Success Rate of Intracytoplasmic Sperm Injection with Azoospermic Male Patients

Factors Influencing Success Rate of Intracytoplasmic Sperm Injection with Azoospermic Male Patients

Report of a Father With Congenital Bilateral Absence of the Vas Deferens Fathering a Child With Beare–Stevenson Syndrome

Congenital Bilateral Absence of the Vas Deferens

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