Relationship of Possible Stress-Related Biochemical Markers to Oxidative/Antioxidative Status in Obsessive-Compulsive Disorder

Behl, Ajay S.; Swami, G.; Sircar, Sabyasachi; Bhatia, Mandeep; Banerjee, B. D.

doi:10.1159/000306591

Cited by 78 publications

(47 citation statements)

References 49 publications

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“…A causal link between these two was also very recently demonstrated by several authors [50][51][52][53][54]. Moreover, different cell types studied in anxious mice showed a strong accumulation of intracellular ROS, in comparison to non-anxious mice, suggesting that oxidative stress is present in various cortex areas, as well as in hippocampus and cerebellum [55,56].…”

Section: Discussionsupporting

confidence: 57%

Effects of angiotensin II receptor antagonists on anxiety and some oxidative stress markers in rat

Ciobîcă

Bild²,

Hrițcu

et al. 2011

Open Medicine

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AbstractIn addition to its known classical roles, the renin angiotensin system (RAS) has more subtle functions which include the regulation of emotional responses. Previous studies regarding the anxiety related behavior of RAS have showed controversial results. There is also evidence that oxidative stress accompanies angiotensin II infusion, but the role of AT1/AT2 specific receptors is not clear. The aim of this study was to evaluate the effects of central angiotensin II receptor blockers on anxiety state and oxidative stress. Behavioral testing included elevated plus maze, while oxidative stress status was measured though the extent of a lipid peroxidation product (malondialdehyde-MDA) and the specific activity of some defense antioxidant enzymes (superoxide dismutase-SOD and glutathione peroxidase-GPx). The rats treated with angiotensin II spent significantly less time in the open-arms of elevated-plus-maze, while the administration of losartan resulted in a significant increase of this time. We observed a significant increase of MDA concentration in the angiotensin II group and a decrease of MDA levels in both losartan and PD-123177 groups. In addition, a significant correlation was seen between the time spent in the open arms and oxidative stress markers. These findings could lead to important therapeutic aspects regarding the use of angiotensin II receptor blockers in anxiety-related disorders.

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Section: Discussionsupporting

confidence: 57%

Effects of angiotensin II receptor antagonists on anxiety and some oxidative stress markers in rat

Ciobîcă

Bild²,

Hrițcu

et al. 2011

Open Medicine

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“…34 Cholesterol deficiency in neuronal membranes may also have a direct negative impact on synapse formation, dendritic outgrowth, and neuronal survival. 35 Moreover, as several studies have 36,37 shown that OCD patients may have increased oxidative stress and that this correlates with disease severity, we may speculate that lipid peroxidation might be one of the causes of reduced serum HDL-C and altered lipid profile in these patients. Alexithymia probably results from an inhibitory mechanism that could contribute to a suppression of emotional processing within the right hemisphere and to poorer verbalization of emotional contents (within the left hemisphere).…”

Section: Discussionmentioning

confidence: 89%

Alexithymia, suicidal ideation, and serum lipid levels among drug-naïve outpatients with obsessive-compulsive disorder

Berardis

Serroni

Marini

et al. 2014

Rev. Bras. Psiquiatr.

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Objective: As obsessive-compulsive disorder (OCD) is a relatively common psychiatric disorder with a significant suicide risk, the individuation of potential biomarkers of suicidality, such as cholesterol levels, may enable recognition of at-risk subjects. Therefore, the aims of this study were to: 1) evaluate potential differences in clinical and laboratory parameters between patients with and without alexithymia and compare them with healthy controls; and 2) investigate which clinical and laboratory variables were associated with suicidal ideation. Methods: 79 drug-naïve adult outpatients with a DSM-IV diagnosis of OCD were recruited. Alexithymia was measured with the 20-item Toronto Alexithymia Scale (TAS-20), suicidal ideation was assessed with the Scale for Suicide Ideation, and depressive symptoms were evaluated with the Montgomery-Å sberg Depression Rating Scale (MADRS). Serum lipid levels of 40 healthy controls were also evaluated. Results: Alexithymic patients had altered serum lipid levels in comparison with non-alexithymics and healthy controls. Using a linear regression model, the presence of symmetry/ordering obsessions and compulsions, lower HDL-C levels, and difficulty in identifying feelings dimension of the TAS-20 were associated with higher suicidal ideation. Conclusions: Alexithymic individuals with OCD may exhibit dysregulation of the cholesterol balance, which in turn may be linked to suicidal ideation. Further prospective studies are required to elucidate this potential association.

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“…One such mechanism may involve oxidative stress, evidence of which has been described in OCD (Behl et al, 2010; Chakraborty et al, 2009; Selek et al, 2008). OCD is associated with polymorphisms of the neuronal glutamate transporter (EAAC1) gene, which mediates cysteine uptake necessary for neuronal glutathione (GSH) production (Aoyama et al, 2006; Monteiro and Feng, 2016).…”

Section: Insights Into Ocd From the Deer Mouse: A Platform For Resmentioning

confidence: 99%

Obsessive-compulsive disorder: Insights from animal models

Szechtman

Ahmari

Beninger

et al. 2017

Neuroscience & Biobehavioral Reviews

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Research with animal models of obsessive-compulsive disorder (OCD) shows the following: (1) Optogenetic studies in mice provide evidence for a plausible cause-effect relation between increased activity in cortico-basal ganglia-thalamo-cortical (CBGTC) circuits and OCD by demonstrating the induction of compulsive behavior with the experimental manipulation of the CBGTC circuit. (2) Parallel use of several animal models is a fruitful paradigm to examine the mechanisms of treatment effects of deep brain stimulation in distinct OCD endophenotypes. (3) Features of spontaneous behavior in deer mice constitute a rich platform to investigate the neurobiology of OCD, social ramifications of a compulsive phenotype, and test novel drugs. (4) Studies in animal models for psychiatric disorders comorbid with OCD suggest comorbidity may involve shared neural circuits controlling expression of compulsive behavior. (5) Analysis of compulsive behavior into its constitutive components provides evidence from an animal model for a motivational perspective on OCD. (6) Methods of behavioral analysis in an animal model translate to dissection of compulsive rituals in OCD patients, leading to diagnostic tests.

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Relationship of Possible Stress-Related Biochemical Markers to Oxidative/Antioxidative Status in Obsessive-Compulsive Disorder

Cited by 78 publications

References 49 publications

Effects of angiotensin II receptor antagonists on anxiety and some oxidative stress markers in rat

Effects of angiotensin II receptor antagonists on anxiety and some oxidative stress markers in rat

Alexithymia, suicidal ideation, and serum lipid levels among drug-naïve outpatients with obsessive-compulsive disorder

Obsessive-compulsive disorder: Insights from animal models

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