Relationship of prognostic factors in stomach cancer with helicobacter pylori: a retrospective study

Abstract

Background and study aims: The prognostic value of H. pylori, which infects more than half of the human population living in the world and plays a role in gastric cancer pathogenesis, is controversial. Our aim is to investigate the relationship between H. pylori and prognostic factors in gastric cancer. Patients and methods: The data of 110 patients (38 females and 72 males) that underwent surgeries due to gastric cancer between 2014 and 2017 were retrospectively analyzed. The relationships between survival (disease-free and overall) and factors such as p53, HER2/neu, Ki-67, neutrophil and platelet lymphocyte ratio (NLR / PLR), histopathological and demographic characteristics were examined. In addition, the results of H. pylori positive and negative groups were compared. Results: Sixty-one (55%) patients were H. pylori negative and 49 (45%) were positive. In multivariate analysis, TNM stage, lymph node capsule invasion and NLR were determined as independent prognostic factors in both disease-free and overall survival. Age>62 and PLR>14.3 were determined as independent predictive factors of poor prognosis in overall survival. In univariate analysis, tumor diameter of >4.3 cm, lymphovascular and perineural invasion, and diffuse p53 expression were determined as predictive factors of poor prognosis in disease-free and overall survival. The effectiveness of these markers in prognosis was not different between H. pylori negative and positive groups. Conclusion: While age, tumor diameter, TNM stage, lymph node capsule invasion, perineural and lymphovascular invasion, diffuse p53, PLR, and NLR were determined as prognostic factors in gastric cancer, these factors were not affected by the presence of H. pylori.

The Survival Relationship between Preoperative Inflammation Markers and Patients with Special Pathological Types of Gastric Cancer

“…At present, Helicobacter pylori ( H. pylori ) has been identified as a carcinogen of gastric cancer [ 34 ]. Remarkably, one out of every two people is infected with Helicobacter pylori worldwide [ 35 ]. Similarly, cancers caused by Helicobacter pylori infection have a higher incidence compared to other various cancers [ 36 ].…”

High prevalence of dermatophytosis of the feet in acral melanoma of the foot

“…9 Chronic infection is potentially related to clinical or subclinical persistent inflammation associated with tumor necrosis factor α, transforming growth factor β (TGFβ), interleukin (IL) 6, and IL-10, which are reported to be involved in both initiation and progression of malignancies. 10 Previous studies have found that persistent inflammation is closely associated with the development of some malignancies, including chronic gastritis due to Helicobacter pylori infection, a cause of gastric cancer 11 ; ulcerative colitis, a cause of colorectal cancer 12,13 ; irritation due to frequent exposure to alcohol and/or tobacco, a cause of esophageal cancer 14,15 ; and hidradenitis suppurativa, a cause of cutaneous squamous cell carcinoma. 16 On the other hand, the sole of the foot is a predilection site of melanoma unlike other cutaneous malignancies such as squamous cell carcinoma and basal cell carcinoma.…”