Relationship of prolactin response to meta‐chlorophenylpiperazine with severity of drug use in cocaine dependence

Patkar, Ashwin A.; Mannelli, Paolo; Hill, Kevin P.; Peindl, Kathleen; Pae, Chi‐Un; Lee, Tong H.

doi:10.1002/hup.780

Cited by 4 publications

(1 citation statement)

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“…Administration of the serotonergic drugs meta-chlorophenylpiperazine (m-CPP, a 5HT1 and 5HT2 receptor agonist (Potenza and Hollander, 2002)) and fenfluramine (a drug inducing 5HT release and having post-synaptic 5HT action (Curzon and Gibson, 1999)) is associated with an exacerbation of OC symptoms and enhanced prolactin release in subjects with OCD (Hollander et al, 1991; Monteleone et al, 1997; Gross-Isseroff et al, 2004). However, groups of children and adults characterized by impulsive aggression exhibit a blunted prolactin response to m-CPP and fenfluramine (Cocarro et al, 1997; Halperin et al, 2003; New et al, 2004b; Patkar et al, 2006). These findings are consistent with those from primates, in which an inverse relationship between aggression and serotonergic activity has been reported (Tiefenbacher et al, 2003)…”

Section: Intermittent Explosive Disorder (Ied)mentioning

confidence: 99%

The relationship between impulse-control disorders and obsessive–compulsive disorder: A current understanding and future research directions

Potenza

Koran

Pallanti

2009

Psychiatry Research

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Impulse control disorders (ICDs) constitute a heterogeneous group of conditions linked diagnostically by difficulties in resisting "the impulse, drive, or temptation to perform an act that is harmful to the person or to others." Specific ICDs share clinical, phenomenological and biological features with obsessive-compulsive disorder (OCD) that have suggested that these disorders might be categorized together. However, other data suggest significant differences between OCD and ICDs. In this article, clinical, phenomenological and biological features of the formal ICDs are reviewed and compared and contrasted with those of OCD. Available data indicate substantial differences between ICDs and OCD that suggest independent categorizations. Existing research gaps are identified and avenues for future research suggested.

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Section: Intermittent Explosive Disorder (Ied)mentioning

confidence: 99%

The relationship between impulse-control disorders and obsessive–compulsive disorder: A current understanding and future research directions

Potenza

Koran

Pallanti

2009

Psychiatry Research

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Quantitative Trait Locus Analysis Identifies Rat Genomic Regions Related to Amphetamine-Induced Locomotion and Gαi3 Levels in Nucleus Accumbens

Potenza

Brodkin

Yang

et al. 2008

Neuropsychopharmacol

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Identification of the genetic factors that underlie stimulant responsiveness in animal models has significant implications for better understanding and treating stimulant addiction in humans. F 2 progeny derived from parental rat strains F344/NHsd and LEW/NHsd, which differ in responses to drugs of abuse, were used in quantitative trait locus (QTL) analyses to identify genomic regions associated with amphetamine-induced locomotion (AIL) and G-protein levels in the nucleus accumbens (NAc). The most robust QTLs were observed on chromosome 3 (maximal log ratio statistic score (LRS max ) ¼ 21.3) for AIL and on chromosome 2 (LRS max ¼ 22.0) for Ga i3 . A 'suggestive' QTL (LRS max ¼ 12.5) was observed for AIL in a region of chromosome 2 that overlaps with the Ga i3 QTL. Noveltyinduced locomotion (NIL) showed different QTL patterns from AIL, with the most robust QTL on chromosome 13 (LRS max ¼ 12.2). Specific unique and overlapping genomic regions influence AIL, NIL, and inhibitory G-protein levels in the NAc. These findings suggest that common genetic mechanisms influence certain biochemical and behavioral aspects of stimulant responsiveness.

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Serotonin function in pathological gambling: blunted growth hormone response to Sumatriptan

et al. 2009

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Pathological gambling is a disruptive behaviour and an important public health concern that is classified as an impulse control disorder, and is also conceptualized as a prototype of 'behavioural addiction'. Its phenomenology cannot be reduced to a single neurobiological dysfunction; instead, it has been conceived as a complex chain of events in which the serotonergic system (5-HT) has often been suggested as one of the most prominent involved. Acute administration of Sumatriptan, a selective 5-HT(1B/1D) agonist, has been used to investigate the functional responsivity of 5-HT(1B/1D) receptors in alcoholics, resulting in a blunted growth hormone response. These findings have been interpreted as being due to the down-regulation of these receptors. However, previous studies could not rule out the possibility that the changes in receptor function were induced by chronic substance exposure. Twenty-two pathological gamblers and 19 healthy control subjects were evaluated in response to double-blind administration of both a single dose of oral Sumatriptan (100 mg) and of placebo in a crossover design. All participants were screened to ensure that they were negative for lifetime alcohol and drug addiction, and had been free of substance abuse for at least 6 months. Outcome measures included growth hormone, prolactin, gambling severity, mood, craving and 'high' change scales. A blunted growth hormone response was observed in pathological gamblers compared with healthy controls after Sumatriptan administration. No statistically significant differences were found for prolactin or behavioural measures, except for an increase in anxiety over time in pathological gamblers. These results, together with those obtained in our previous serotoninergic challenge study, document the presence of a serotonergic dysfunction in pathological gamblers similar to that reported in alcoholics.

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Relationship of prolactin response to meta‐chlorophenylpiperazine with severity of drug use in cocaine dependence

Abstract: The results indicate that disturbances in 5-HT function as reflected by a blunted response to m-CPP seem to be primarily associated with severity of drug use and to a lesser, although significant extent with behavioral traits in cocaine-dependent patients.

Cited by 4 publications

References 64 publications

The relationship between impulse-control disorders and obsessive–compulsive disorder: A current understanding and future research directions

The relationship between impulse-control disorders and obsessive–compulsive disorder: A current understanding and future research directions

Quantitative Trait Locus Analysis Identifies Rat Genomic Regions Related to Amphetamine-Induced Locomotion and Gαi3 Levels in Nucleus Accumbens

Serotonin function in pathological gambling: blunted growth hormone response to Sumatriptan

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