Relationship of PROP (6-n-propylthiouracil) taster status with body mass index, food preferences, and consumption of Filipino adolescents

Villarino, Blanca J.; Magbuhat, Rizza Marie T.; Sabandal, Maria Lourdes

doi:10.1016/j.foodres.2011.06.034

Cited by 13 publications

(18 citation statements)

References 55 publications

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“…In the present study, the classification of the children's taste sensitivity based on PROP test strips led to 13% nontasters, 51% medium-tasters, and 36% supertasters (Table 6). This distribution is in accordance with a previous taste sensitivity study that reported the clusters of the taste phenotype consisting of 7% nontasters, 59% medium-tasters, and 34% supertasters in 13-17-year-old children [74]. Additionally, Mennella et al [75] also concluded that there are age differences in PROP responsiveness, suggesting that when matched for the TAS2R38 genotype, children tend to be more sensitive than adults.…”

Section: Relationships Between Taste Sensitivities Measured By Differsupporting

confidence: 90%

Investigating the Relationships between Basic Tastes Sensitivities, Fattiness Sensitivity, and Food Liking in 11-Year-Old Children

Ervina

Berget

Almli

2020

Foods

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This study investigates the relationships between basic tastes and fattiness sensitivity and food liking in 11-year-old children. The basic taste sensitivity of 106 children was measured using different methods, namely detection (DT) and recognition (RT) thresholds, and taste responsiveness. Caffeine and quinine (bitter), sucrose (sweet), citric acid (sour), sodium chloride (salty), and monosodium glutamate (umami) were investigated for DT and RT at five concentrations in water solutions. In addition, taste responsiveness and liking were collected for the high-intensity concentrations. PROP (6-n-propylthiouracil) responsiveness was tested on paper strips. Fattiness sensitivity was measured by a paired comparison method using milk samples with varying fat content. Liking for 30 food items was recorded using a food-list questionnaire. The test was completed in a gamified “taste detective” approach. The results show that DT correlates with RT for all tastes while responsiveness to PROP correlates with overall taste responsiveness. Caffeine and quinine differ in bitterness responsiveness and liking. Girls have significantly lower DTs than boys for bitterness and sweetness. Food liking is driven by taste and fattiness properties, while fatty food liking is significantly influenced by fattiness sensitivity. These results contribute to a better holistic understanding of taste and fattiness sensitivity in connection to food liking in preadolescents.

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Section: Relationships Between Taste Sensitivities Measured By Differsupporting

confidence: 90%

Investigating the Relationships between Basic Tastes Sensitivities, Fattiness Sensitivity, and Food Liking in 11-Year-Old Children

Ervina

Berget

Almli

2020

Foods

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“…Goldstein and colleagues (60) did not find a relationship between PROP status and BMI percentile in preadolescent children, even though nontasters in this study reported consuming more daily energy compared with supertasters. In addition, no relationship was found between PROP taster status and BMI in a sample of 120 Filipino adolescents ages 13 to 17 (22), but null results may be due to ethnic and cultural differences. Other studies conducted in ethnically and socioeconomically diverse cohorts also dispute the notion that PROP insensitivity is a marker for higher body weights in children.…”

Section: Prop Status Tas2r38 and Body Weightmentioning

confidence: 81%

“…The majority of studies that have found differences between dietary intake as a function of PROP status have utilized food frequency questionnaires (77,78) or measured ad libitum intake (15,54,75). Most studies that have used self-report diet recalls or food diaries have not seen any relationship with PROP status (5,22,50,101,102,134). The biases inherent in methods for dietary reporting have been thoroughly discussed, and all methods have obvious strengths and limitations.…”

Section: Conclusion and Directions For Future Studiesmentioning

confidence: 99%

Variation in the Ability to Taste Bitter Thiourea Compounds: Implications for Food Acceptance, Dietary Intake, and Obesity Risk in Children

Keller

Adise

2016

Annu. Rev. Nutr.

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The ability to taste bitter thiourea compounds, such as phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP), is inherited. Polymorphisms in the bitter-taste receptor TAS2R38 explain the majority of phenotypic variation in the PROP phenotype. It has been hypothesized that the PROP phenotype is a marker for perception of a variety of chemosensory experiences. In this review, we discuss studies that have investigated the relationship between bitter-taste response and dietary behaviors and chronic health in children. Investigators have hypothesized that children who are PROP tasters have lower liking and consumption of bitter foods, such as cruciferous vegetables. Additionally, several studies suggest that children who are unable to taste PROP (i.e., nontasters) like and consume more dietary fat and are prone to obesity. The relationship between the PROP phenotype and obesity is influenced by multiple confounders, including sex, food access, ethnicity, and socioeconomic status. Future studies that adjust for these variables are needed.

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“…Taste perception was assessed in all 13 papers: 5 papers conducted taste phenotype measures [40][41][42]47,52], 3 papers conducted taste genotype measures [45,50,51], and 5 papers measures both phenotype and genotype [43,44,46,48,49].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Bitter was the most studied taste in 9 papers. 6 papers used 6-n-propylthiouracil (PROP) [40,41,43,44,48,49] and 1 used phenylthiocarbamide (PTC) [52] to test bitter taste, while 6 papers genotyped the following single-nucleotide polymorphisms (SNPs): rs713598, rs1726866, and rs10246939 in the gene TAS2R38 [43][44][45][46]48,49].…”

Section: Study Characteristicsmentioning

confidence: 99%

Impact of Taste on Food Choices in Adolescence—Systematic Review and Meta-Analysis

et al. 2020

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Studies of adults report that perceived taste affects food choices and intake, which in turn may have an impact on health. However, corresponding evidence on adolescents is limited.  Our aim was to summarize current evidence of the impact of taste perception on food choice preferences or dietary intakes among adolescents (mean age 10–19.9 years). Systematic searches identified 13 papers, 12 cross-sectional and one cohort study published between 1 January 2000 to 20 February 2020 assessing the impact of taste (using phenotypic and/or genotypic markers) on food choices in adolescents without any disease conditions. Qualitative assessment in the current review indicated that individuals sensitive to bitter tastes often have a lower preference of bitter-tasting food and higher preference for sweet-tasting food. A meta-analysis of three studies on bitter-taste sensitivity revealed no difference in preference for bitter-tasting vegetables between bitter tasters and non-tasters (standardized mean difference (SMD) = 0.04; 95% CI: −0.18, 0.26; p = 0.72). Overall, a limited number of studies were available for review. As a result, we report no clear relationship between taste perception and food choices or intake in adolescents. More studies are needed to evaluate the link between adolescents’ taste perceptions and dietary intake.

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Relationship of PROP (6-n-propylthiouracil) taster status with body mass index, food preferences, and consumption of Filipino adolescents

Cited by 13 publications

References 55 publications

Investigating the Relationships between Basic Tastes Sensitivities, Fattiness Sensitivity, and Food Liking in 11-Year-Old Children

Investigating the Relationships between Basic Tastes Sensitivities, Fattiness Sensitivity, and Food Liking in 11-Year-Old Children

Variation in the Ability to Taste Bitter Thiourea Compounds: Implications for Food Acceptance, Dietary Intake, and Obesity Risk in Children

Impact of Taste on Food Choices in Adolescence—Systematic Review and Meta-Analysis

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