Relationship of Red Cell Distribution Width With the Presence and Severity of Preeclampsia

Kurt, Raziye Keskin; Aras, Zinnur; Şilfeler, Dilek Benk; Kunt, Cigdem; Islimye, Mine; Kosar, Ozlem

doi:10.1177/1076029613490827

Cited by 56 publications

(77 citation statements)

References 25 publications

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“…They are the first blood cells responding to inflammation [4]. Kurt et al, reported higher neutrophil counts in preeclamptic patients, implying the presence of an increased inflammatory state [9]. Our findings are consistent with their results as we detected the mean neutrophil count in the first trimester to be significantly higher in the group with preeclampsia.…”

Section: Discussionsupporting

confidence: 92%

High first-trimester neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios are indicators for early diagnosis of preeclampsia

Gezer¹,

Ekin²,

Ertaş³

et al. 2016

Ginekol Pol

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Objectives: The aim of our study is to determine whether first-trimester neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) would be useful as new predictors of subsequent preeclampsia. Material and methods:Medical records of women with preeclampsia and healthy controls from a tertiary referral center were retrospectively evaluated. The two groups were compared in terms of clinical characteristics and first-trimester levels of hemoglobin, leukocyte, neutrophil, lymphocyte, platelet, NLR and PLR. Receiver operating characteristic curve (ROC) analysis was performed to identify the optimal NLR and PLR levels predicting preeclampsia.Results: Neutrophil (p < 0.001), platelet (p < 0.001), NLR (p < 0.001) and PLR (p < 0.001) levels were significantly elevated, whereas hemoglobin concentration (p = 0.003) was significantly lower in the group with preeclampsia as compared to the control group. On multivariate regression analysis, NLR (OR 1.43; 95% CI 1.21-1.76; p = 0.005) and PLR (OR 1.38; 95% CI 1.15-1.63; p = 0.008) were the most powerful predictive variables. The area under the ROC was 0.716 and 0.705 for NLR and PLR, respectively. The cut-off values of NLR ≥ 3.08 and PLR ≥ 126.8 predicted preeclampsia with the sensitivity of 74.6% and 71.8% and specificity of 70.1% and 72.4%, respectively. Conclusions:High NLR and PLR during the first trimester are independent predictors of subsequent preeclampsia.

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Section: Discussionsupporting

confidence: 92%

High first-trimester neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios are indicators for early diagnosis of preeclampsia

Gezer¹,

Ekin²,

Ertaş³

et al. 2016

Ginekol Pol

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“…The mean RDW and MPV were significantly low in preeclampsia group than the control group in our study, conflicting with the results of previous studies which have performed the CBC test after the diagnosis of preeclampsia 2,11,17 . However, in a study designed similar to ours, Myatt et al have reported higher first trimester MPV levels in patients who later developed preeclampsia 20 .…”

Section: Discussioncontrasting

confidence: 99%

“…Kurt et al and Oylumlu et al have reported higher WBC counts and neutrophil counts in preeclamptic patients, implying that there is an increased inflammatory state 11,18 . The relation between increased WBC and preeclampsia has been explained by increased inflammation in these patients.…”

Section: Discussionmentioning

confidence: 95%

“…Shortening of the lives of erythrocytes by defective erythropoiesis, by inflammation or hemolysis, results in elevation of RDW11. Elevated RDW level has been used as a marker for increased systemic inflammation 11 . Recent studies have reported that high RDW level is also associated with non-dipper hypertension, presence and severity of hypertension in nonpregnant people and poor prognosis in various clinical circumstances such as heart failure and coronary artery diseases6.…”

Section: Discussionmentioning

confidence: 99%

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The value of red cell distribution width for predicting subsequent preeclampsia

Gezer¹,

Ekin²,

Solmaz³

et al. 2016

Cukurova Med J

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AbstractÖz Purpose: The purpose of our study was too assess the diagnostic value of red cell distribution width and other inflammatory markers such as white blood cell count and mean platelet volume during the first trimester of gestation for predicting the subsequent development of preeclampsia. Material and Methods: A retrospective study was performed on 137 patients with preeclampsia and 150 normotensive pregnant women. Study group was assessed for presence of preeclampsia and the values of first trimester red cell distribution width, white blood cell count and mean platelet volume. The receiver operator curve was used to evaluate cut-off, sensitivity and specificity values. Results:The optimal cut-off points to predict preeclampsia were a white blood cell count 10200 cells/mm3 or higher with a sensitivity of 75.1% and specificity of 44.1%, a mean platelet volume 8.6fL or lower with a sensitivity of 62.5% and specificity of 64.4% and a red cell distribution width 15.3% or lower with a sensitivity of 31.2% and specificity of 79.7%. Conclusion: Regarding the association between first trimester red cell distribution width, white blood cell count and mean platelet volume, statistical analysis revealed that these markers were weak predictors of preeclampsia.Amaç: Bu çalışmanın amacı ilk trimester eritrosit dağılım genişliği, lökosit sayısı ve ortalama platelet hacmi gibi inflamatuar markerların sonradan gelişen preeklampsiyi belirlemedeki tanısal değerini belirlemektir. Gereç ve Yöntem: Preeklampsili 137 hasta ve 150 normal tansiyonlu hasta retrospektif olarak incelendi. Çalışma grubu preeklampsinin varlığına ve ilk trimester eritrosit dağılım genişliği, lökosit sayısı ve ortalama platelet hacmi açısından değerlendirildi. Eşik değeri, sensitivite ve spefisite değerlerini belirmek için ROC eğrisi kullanıldı. Bulgular: Preeklampsiyi öngörmede lökosit için optimal eşik değeri ≥10200 hücre/mm3, sensitivite %75.1 ve spesifisite %44.1; ortalama platelet hacmi için optimal eşik değeri ≤ 8.6fL, sensitivite %62.5 ve spesifisite %64.4; eritrosit dağılım genişliği için optimal eşikd eğeri %15.3, sensitivite %31.2 ve spesifisite %79.7 olarak belirlendi. Sonuç: İlk trimester eritrosit dağılım genişliği, ortalama platelet hacmi ve lökosit değerleri preeklampsiyi öngörmede zayıf öngörücü belirteçlerdir.

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“…Erdoğan et al found no association between RDW levels and gestational diabetes mellitus [24]. Kurt et al found that RDW was associated with preeclampsia and with severity of the disease [25] .Otherwise Abdullahi et al could not find an association between serum RDW level and the presence of preeclampsia [26]. However, little is known and there is no study about if there is an association between RDW level and ICP.…”

Section: Discussionmentioning

confidence: 99%

Elevated red blood cell distribution width is associated with intrahepatic cholestasis of pregnancy

Yılmaz¹,

Türkmen²,

Dağlar³

et al. 2017

Ginekol Pol

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Objectives: Intrahepatic cholestasis of pregnancy is the most common pregnancy specific liver disease and related with adverse maternal and perinatal outcome. Red blood cell distribution width, an anisocytosis marker in a complete blood count, has been used as an inflammation marker in various diseases. However the association of red blood cell distribution width with intrahepatic cholestasis of pregnancy is unknown. We aimed to evaluate the relationship between red blood cell distribution width and intrahepatic cholestasis of pregnancy. Material and methods:Ninety pregnant women with intrahepatic cholestasis of pregnancy and ninety healthy pregnant women were included in the study. Their clinical and laboratory characteristics including red blood cell distribution width, liver function tests, fasting and postprandial bile acid concentrations were analyzed.Results: Serum red blood cell distribution width cell levels were significantly higher in pregnants with intrahepatic cholestasis of pregnancy than healthy pregnants. We also demonstrated that red blood cell distribution Width levels were higher in severe disease than mild disease and was significantly correlated with fasting and postprandial bile acid concentration in intrahepatic cholestasis of pregnancy group. Conclusions:Our study showed that red blood cell distribution width, an easy and inexpensive marker; were associated with intrahepatic cholestasis of pregnancy and can be used as a diagnostic and prognostic marker in intrahepatic cholestasis of pregnancy.

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Relationship of Red Cell Distribution Width With the Presence and Severity of Preeclampsia

Abstract: Our study results revealed that RDW levels were associated with both the presence and the severity of preeclampsia.

Cited by 56 publications

References 25 publications

High first-trimester neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios are indicators for early diagnosis of preeclampsia

High first-trimester neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios are indicators for early diagnosis of preeclampsia

The value of red cell distribution width for predicting subsequent preeclampsia

Elevated red blood cell distribution width is associated with intrahepatic cholestasis of pregnancy

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