Relationship of regional adiposity to insulin resistance and serum triglyceride levels in nonobese Japanese type 2 diabetic patients

Taniguchi, Ataru; Nakai, Yoshikatsu; Sakai, Masahiko; Yoshii, Satoru; Hamanaka, D; Hatae, Yasuhiko; Kawata, Mayumi; Yamanouchi, Kazufumi; Okumura, Takako; Doi, Kentaro; Tokuyama, Kumpei; Nagasaka, Shoichiro; Fukushima, Mitsuo

doi:10.1053/meta.2002.31984

Cited by 67 publications

(57 citation statements)

References 36 publications

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“…In recent years, the association of obesity, diabetes mellitus, hypertriglycedemia, and hypertension with insulin resistance has been well recognized [4]. [5] It has also been reported that the patients with fatty liver was associated with insulin resistance and obesity. [10], [12] This study showed that elevations in plasma ALT and Ch-E levels could represent fatty liver, so that fatty liver played an important role of insulin sensitivity in the lean men as well as in the normal weight or the obese men.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Insulin Resistance in Japanese Men Working Abroad.

Iizuka¹,

Uchikoshi²,

Koga³

et al. 2003

HEP

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Section: Discussionmentioning

confidence: 99%

Characteristics of Insulin Resistance in Japanese Men Working Abroad.

Iizuka¹,

Uchikoshi²,

Koga³

et al. 2003

HEP

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“…Martin et al (1985) also noted that the high backfat Ossabaw sows had higher serum triglyceride levels. In healthy men, high fat content was associated with elevated total serum triglyceride (Walton et al, 1995), and visceral abdominal fat was also positively associated with serum triglyceride level in Japanese (Taniguchi et al, 2002). The above studies indicated that fat deposition can be -E-mail: nyxu@zju.edu.cn influenced by the concentration of circulating triglyceride and APOA5 may play an important role in fat deposition.…”

Section: Introductionmentioning

confidence: 95%

Molecular cloning, expression and polymorphism of the porcine apolipoprotein A5 gene in a Jinhua × Pietrain F2 reference population

Zhang

Jiang

Hua

et al. 2010

Animal

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As a newly described member of the apolipoprotein gene family, apolipoprotein A5 (APOA5) has been suggested to play a key role in the triglyceride metabolism in both human and mice. The aim of this study was to identify the porcine (Sus scrofa) APOA5 gene, determine its mRNA and its mutations that are associated with lipid accumulation. The porcine APOA5 cDNA was amplified by reverse transcriptase polymerase chain reaction using the information of the mouse or other mammals. It had been determined that the open reading frame of the porcine APOA5 gene consists of 1092 bp, which encodes a predicted protein composed of 363 amino acids with a similarity to bovine (80.43%) and to human (78.47%). The expression analysis indicated that the porcine APOA5 gene was expressed in hypophysis, fat and liver. Twelve single nucleotide polymorphisms (SNPs), including 4 SNPs in the 5 0 end, 1 SNP in second intron, 1 SNP in third exon and 6 SNPs in the 3 0 end, were identified in the porcine APOA5 gene and genotyped on the Jinhua 3 Pietrain F 2 reference population, it had revealed that the SNP of C1834T was significantly associated with average backfat thickness and leaf fat weight ( P , 0.01 and P , 0.05, respectively). In conclusion, this study has got basic information of the porcine APOA5 gene and provides evidence that the APOA5 gene could be a potential candidate gene for fat deposition.

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“…The importance of obesity as a risk factor for hyperlipidemia, type 2 diabetes, and hypertension is well recognized (1)(2)(3). Also, visceral fat accumulation is a well-known risk factor for cardiovascular disease (4)(5)(6). Restriction of lipid intake is an efficient strategy for preventing weight gain/fat deposition (7).…”

Section: Introductionmentioning

confidence: 99%

Effects of Margarine Containing Medium-chain Triacylglycerols on Body Fat Reduction in Humans

Nosaka

Maki

Suzuki

et al. 2003

JAT

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We found previously that the ingestion of margarine containing medium-chain triacylglycerols (MCT) resulted in a significant increase in postprandial thermogenesis when compared with long-chain triacylglycerols (LCT). Diets that included margarine containing MCT and LCT were compared for 12 weeks in 73 subjects to investigate the effects on body weight, body fat, areas of subcutaneous and visceral fat, serum total cholesterols, triglycerides, lipoproteins, plasma glucose, serum insulin, total ketone bodies, and the activities of aspartate aminotransferase, alanine aminotransferase, and γ-glutamyltranspeptidase. We conducted a double-blind, controlled study and used blended rapeseed oil and soybean oil (LCT) as a comparison. Two groups ingested 2,100-2,400 kcal/day of energy, 65-73 g/day of total fat, and 14 g/day of test margarine (5 g/day of MCT or LCT). The subjects on the MCT diet demonstrated significant decreases in body fat weight (-3.8 ± 2.4 kg vs -2.4 ± 1.7 kg; MCT vs LCT, mean ± SD), subcutaneous fat (-38.2 ± 29.9 cm 2 vs -22.6 ± 19.3 cm 2 ), and visceral fat (-12.2 ± 11.2 cm 2 vs -1.6 ± 12.8 cm 2 ) after 12 weeks. There were no clinical differences in measured blood parameters. We suggest that the postprandial increase in thermogenesis and control of postprandial triglyceride levels may explain these results. J Atheroscler Thromb, 2003; 10: 290-298.

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Relationship of regional adiposity to insulin resistance and serum triglyceride levels in nonobese Japanese type 2 diabetic patients

Cited by 67 publications

References 36 publications

Characteristics of Insulin Resistance in Japanese Men Working Abroad.

Characteristics of Insulin Resistance in Japanese Men Working Abroad.

Molecular cloning, expression and polymorphism of the porcine apolipoprotein A5 gene in a Jinhua × Pietrain F2 reference population

Effects of Margarine Containing Medium-chain Triacylglycerols on Body Fat Reduction in Humans

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