2009
DOI: 10.1016/j.jpedsurg.2009.01.043
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Relationship of serum C-reactive protein and blood glucose levels with injury severity and patient morbidity in a pediatric trauma population

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Cited by 16 publications
(10 citation statements)
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“…Additionally, rRV physiology was associated with higher CRP levels in the early postoperative period, indicating a greater systemic inflammatory response. CPB‐associated systemic inflammatory response has mostly been attributed to intraoperative factors, such as interaction of blood components with the artificial surfaces of the extracorporeal circuit, surgery trauma, and myocardial ischemia–reperfusion injury . However, few studies have shown a positive correlation between the duration of CPB and the peak levels of CRP, and no correlation was found between CRP levels and CPB or ACC time in our data.…”
Section: Discussioncontrasting
confidence: 67%
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“…Additionally, rRV physiology was associated with higher CRP levels in the early postoperative period, indicating a greater systemic inflammatory response. CPB‐associated systemic inflammatory response has mostly been attributed to intraoperative factors, such as interaction of blood components with the artificial surfaces of the extracorporeal circuit, surgery trauma, and myocardial ischemia–reperfusion injury . However, few studies have shown a positive correlation between the duration of CPB and the peak levels of CRP, and no correlation was found between CRP levels and CPB or ACC time in our data.…”
Section: Discussioncontrasting
confidence: 67%
“…C‐reactive protein (CRP) is a marker of systemic inflammatory response in critically ill patients, including heart failure patients and those who have recently undergone cardiopulmonary bypass surgery (CPB) . CRP has been demonstrated to be an independent predictor of morbidity and mortality in children undergoing noncardiac and cardiac surgeries . Changes in levels of CRP after CPB have been attributed in part to the different conditions of systemic oxygen transport in different circulations after complete repair or palliation…”
Section: Introductionmentioning
confidence: 99%
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“…Their growth was observed in several studies concerning single and multiple injuries, and also the reaction to planned surgery. The highest levels were observed during the first 2–3 days after injury with subsequent decrease on the fifth day [ 4 , 7 , 16 18 ]. In our research the same course of changes in the levels of IL-6 and IL-8 was observed.…”
Section: Discussionmentioning
confidence: 99%
“…Metabolic responses to surgical injury are partly regulated by two processes, the acute phase and the glycemic response. During the first phase, Interleukin (IL)-6 stimulates the liver to produce proteins, such as C-reactive protein (CRP), proportionally to the dimension of the injury and typically reaching a peak within 72 h [1]. Soon after, the glycemic response occurs, resulting in hyperglycemia proportional to the extent of the injury [2].…”
Section: Introductionmentioning
confidence: 99%