Relationship of serum salusin beta levels with coronary slow flow

Akyüz, Aydın; Aydin, Fatma; Alpsoy, Şeref; Gür, Demet Özkaramanlı; Güzel, Savaş

doi:10.14744/anatoljcardiol.2019.43247

Cited by 4 publications

(5 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several possible mechanisms have been proposed, such as the endothelial dysfunction theory 28 , early atherosclerosis 29 , microvascular disease 5 , 30 , platelet dysfunction 31 , changes in hemorheology 32 , 33 , and oxidative stress and local/systemic inflammatory response 3 – 5 . Recently, some studies have indicated that lipoprotein-associated phospholipase A2 34 , plasma choline 35 , or serum salusin beta level 36 could be a predictive or diagnostic biomarker for CSF.…”

Section: Discussionmentioning

confidence: 99%

The effect of coronary slow flow on left atrial structure and function

Shui

Sun

Gao

et al. 2021

Sci Rep

View full text Add to dashboard Cite

The coronary slow flow phenomenon (CSFP) is common in coronary angiography, however its impact on left atrial (LA) function is still controversial. This study aims to evaluate the LA structure and function of patients with CSFP using two-dimensional speckle tracking echocardiography (2D-STE). Consecutive patients scheduled for coronary angiography from January 2016 to September 2017 were enrolled in this study. Patients’ demographic data, clinical histories, laboratory and angiographic findings were collected and recorded. Diagnostic criteria for CSFP is based on Beltrame et al. proposed in 2012. Meanwhile 139 patients who have no significant stenosis (≤ 40%) and normal blood flow were selected as control. All patients received an echocardiographic examination 24 h before coronary angiography. LA structure and function were measured with echocardiography and 2D-STE. Our results showed that among the 1,954 patients who had received coronary angiography, 512 patients were included in the analysis after the exclusion criteria was implemented. Of those, 101 patients met the CSFP criteria (5.5%). CSFP is mainly seen in LAD (~ 70%). There was no statistical difference in baseline characteristics between the CSFP group and control group, except for a higher proportion of smokers in the CSFP group (P = 0.001). The percentage of monocytes is an independent risk factor for the occurrence of CSFP (P = 0.036) after binary logistic regression analysis. The LA global longitudinal strain (LA-GLS, represents reservoir functions) decreased and LA strain rate at late diastole (LA-SRa, represents booster function) increased in patients with CSFP compared to the control group (P < 0.05). Correlation test of continuous variables by Pearson test suggested that LA-GLS was negatively correlated with TIMI frame count (TFC). We concluded that the percentage of monocytes is an independent risk factor for the CSFP; the LA reservoir and booster functions were impaired in patients with CSFP; LA-GLS is negatively correlated with TFC.

show abstract

Section: Discussionmentioning

confidence: 99%

The effect of coronary slow flow on left atrial structure and function

Shui

Sun

Gao

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…We read the study entitled "Relationship of serum salusin beta levels with coronary slow flow" by Akyüz et al (1) with great interest. In their study, they reported that salusin-β concentrations were associated with the coronary slow-flow phenomenon.…”

Section: Letters To the Editormentioning

confidence: 99%

“…If not, the reliability of the results is doubtful. Therefore, we wish to make the following contributions to this study conducted by Akyüz et al (1).…”

Section: Letters To the Editormentioning

confidence: 99%

“…In their studies, the authors examined solely the levels of salusin-β and did not follow an optimal way to collect samples during sample collection. For example, because salusin-β studied by them adhered to the edges of propylene biochemistry tubes, its concentrations were measured to be extremely low if low doses of NP-40 or Tween-20 were not included (2), which has not been mentioned in the Material and Method section of the study by Akyüz et al (1). Furthermore, the authors stated that they received 500 Kallikrein Inhibitor Units (KIU) in biochemistry tubes containing aprotinin to protect them from salusin-β protease enzymes.…”

Section: Letters To the Editormentioning

confidence: 99%

“…To the Editor, NP-40 and Tween-20 are two detergents for cell lysis and protein extraction that have hydrophobic-hydrophilic interactions among molecules in biological specimens. They are used to lyse cells to release soluble proteins that are present in a cell and are used in both immunoassay and electrophoresis procedures (1,2). We measured salusin-β levels using ELISA in serum samples (3).…”

Section: Author`s Replymentioning

confidence: 99%

See 2 more Smart Citations

Measurement of salusin-ß twithout addition of NP-40 or Tween-20 in coronary slow flow

Aydın¹,

Yardım

Akkoç

2019

Anatol J Cardiol

View full text Add to dashboard Cite

Salusin beta, atherosclerosis and coronary slow flow

Akıncı

Çoner²

2019

Anatol J Cardiol

View full text Add to dashboard Cite

To the Editor, We have read the paper written by Akyüz et al. (1) titled "Relationship of serum salusin beta levels with coronary slow flow" with great interest. In this research, the authors compared serum salusin-β levels between two patient groups, those with normal coronary arteries and those with coronary slow flow (CSF) pattern in the absence of significant coronary artery disease. They concluded that serum salusin-β levels could play a role as a biomarker for the evaluation of CSF. In previous studies, salusin-β has been reported to be related to the development and progression of atherosclerosis, and it has been shown that the circulating levels are high in patients with documented atherosclerosis (2, 3). On the other hand, atherosclerotic plaques are also abundant for consistent salusin-β release. In a previous intravascular ultrasound study, Cin et al. (4) have demonstrated the association of subclinical atherosclerosis with CSF. Therefore, we believe that the increased serum salusin-β levels in patients with CSF may be the effect of subclinical atherosclerosis and can not be evaluated as a biomarker for CSF. Morever, in the study group, patients with nonsignificant atherosclerosis have not been excluded, and this might be a factor for the increased serum salusin-β levels observed in this group. The hypothesis regarding the role of serum salusin-β levels in CSF should be tested between patient groups with similar atherosclerotic plaque burden.

show abstract

Relationship of serum salusin beta levels with coronary slow flow

Cited by 4 publications

References 42 publications

The effect of coronary slow flow on left atrial structure and function

The effect of coronary slow flow on left atrial structure and function

Measurement of salusin-ß twithout addition of NP-40 or Tween-20 in coronary slow flow

Salusin beta, atherosclerosis and coronary slow flow

Contact Info

Product

Resources

About