Relationship of Serum Total IgE and Cell-Mediated Immunity in Patients with Hodgkin’s Disease

Rubinstein, Elliot; Sokal, Joseph E.; Reisman, Robert E.; Arbesman, Carl E.

doi:10.1159/000231955

Cited by 9 publications

(6 citation statements)

References 8 publications

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“…The current analyses support the earlier results in relation to B-cell lymphoma, but not HL, where we found a protective effect for both total and specific serum IgE. The majority of previous studies have reported an increased risk of HL with elevated IgE levels (15,16). Nonetheless, a recent large case-control study, using data from population based registries, reported asthma to be associated with a significantly decreased risk of HL (OR, 0.6; 95% CI, 0.4-0.9; based on 18 exposed cases), which is in accordance with our current results; after an induction period of 10 years after first asthma diagnosis, the OR was still below unity (OR, 0.7), but the result was no longer statistically significant (8).…”

Section: Discussionsupporting

confidence: 92%

“…Several large cohort linkage studies have reported no association with cancer risk and atopy or allergy (11,12). Elevated serum IgE levels have been reported in HL (13,14) and advanced stage of HL disease has also been found to correlate with elevated IgE (15). Eosinophilia, a hallmark of atopy, is also frequently observed among HL patients (16).…”

Section: Introductionmentioning

confidence: 99%

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Immunoglobulin E Levels and Risk of Lymphoma in a Case-Control Study in Spain

Ellison‐Loschmann

Benavente

Douwes

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Epidemiologic studies have shown an inverse association between atopy and malignant lymphoma, but results are inconsistent. We investigated levels of IgE, before and after commencement of treatment, and evaluated lymphoma risk in relation to total and specific IgE levels. Serum levels of IgM, IgA, and IgG were also measured. We enrolled 467 newly diagnosed lymphoma cases and 544 hospital controls, matched for age, sex, and hospital. Lymphomas were histologically confirmed and categorized according to the WHO classification. Subjects provided blood for analysis of total and specific IgE levels, and total IgM, IgA, and IgG levels. Additional information was collected by intervieweradministered questionnaire. Controlling for age, sex, center, smoking status, and any treated asthma or eczema, we found that the overall risk of lymphoma was significantly lower in the high [odds ratio (OR), 0.39; 95% confidence interval (95% CI), 0.28-0.54] and middle (OR, 0.55; 95% CI, 0.40-0.74) tertiles for total serum IgE compared with the low tertile. Specific IgE to common aeroallergens (defined as z0.35 kU/L) was also inversely associated with risk of lymphoma (OR, 0.67; 95% CI, 0.45-1.00). Lymphoma was associated with IgA and IgM but not IgG. Mean levels of all immunoglobulins were decreased with more advanced malignancy, and total serum IgE levels were lower before treatment. The data suggest that the low levels of immunoglobulins seen in a wide range of lymphoma cases is likely to be linked to a lymphogenesis process rather than resulting from a selective protection due to an atopic process. Long-term cohort studies may be fundamental to fully evaluate these associations. (Cancer Epidemiol Biomarkers Prev 2007;16(7):1492 -8)

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Immunoglobulin E Levels and Risk of Lymphoma in a Case-Control Study in Spain

Ellison‐Loschmann

Benavente

Douwes

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Elevated IgE levels have been reported in Hodgkin's lymphoma (HL) and advanced stage of HL disease has also been found to be correlated with elevated IgE [78]. …”

Section: Discussionmentioning

confidence: 99%

Levels of certain tumor markers as differential factors between bilharzial and non-biharzial bladder cancer among Egyptian patients

Metwally

Ali

Mohamed

et al. 2011

Cancer Cell International

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Background/ObjectiveBladder cancer is the commonest type of malignant tumors as a result of schistosomaisis which is a major healthy problem in many subtropical developing countries. The aim of this study is to comparatively elucidate the underlying biochemical tumor markers in schistosomal bladder cancer versus non-schistosomal bladder cancer when compared to normal healthy ones.MethodsThis work was performed on tissue specimens from total 25 patients and serum samples from total 30 patients versus ten healthy individuals served as control. The investigated parameters in serum are: xanthine oxidase (XO), fructosamine, lactate dehydrogense (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), total proteins, essential and non- essential amino acids profile, hydroxyproline, total immunoglobulin E (IgE) and tumor necrosis factor alpha (TNF-α). In addition, the current investigation also extended to study some markers in tumor bladder tissues including, pyruvate kinase enzyme (PK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST) and alanine aminotransferase (ALT).ResultsResults showed that biharzial bladder cancer patients recored more significant elevation in serum XO, fructosamine, LDH, AST, ALT, hydroxyproline, IgE and TNF-α than in bladder cancer patients when compared to control ones. While, in tissues there were significant increase in PK, LDH, AST & ALT activities of schistosomal bladder cancer than in bladder cancer as compared to control healthy patients.ConclusionsIt could be concluded that, bilharzial and non-bilharzial bladder cancer showed distinct biochemical profile of tumor development and progression which can be taken into consideration in diagnosis of bladder cancer.

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“…Conversely, many observations report high TE levels in those situations where at least some T-cell functions are reduced. In diseases such as Hodgkin's disease (30), Wiskott-Aldrich syndrome (31), and infectious mononucleosis (32) where Tcell function is suppressed and after T-suppressive manipulations such as thymectomy (33), irradiation (34), and treatment with antilymphocyte serum (35), TE production is enhanced. Indeed, a soluble factor apparently obtained from thymocytes has been isolated that can suppress TE responses (36).…”

Section: Discussionmentioning

confidence: 99%

The effect of anti-mu suppression of gammaM and gammaG on the production of gammaE.

Dwyer

Rosenbaum

Lewis

1976

The Journal of Experimental Medicine

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Newbonr mice were treated from the day of birth with either bovine gamma globulin or anti-mu chain sera. The latter was administered using a protocol known to produce suppression of gammaM, gammaG, and gammaA production. Subsequent immunization with ovalbumin (OA) in alum was attempted to see if suppression of gammaM, gammaG, and gammaA classes of antibody would also be accompanied by suppression of gammaE-producing capacity. gammaG and gammaM antibody to OA and mercaptoethanol-resistant (gammaG) antibody to OA were measured by passive hemagglutination; gammaG and gammaE anti-OA antibodies were measured by passive cutaneous anaphylaxis. Anti-mu suppression was achieved with significant reduction in gammaM and gammaG antibodies. gammaE antibodies were not affected, suggesting an ontogenetic development for gammaE-bearing lymphocytes independent of the previously described gammaM to gammaG to gammaA ontogenetic sequence.

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Relationship of Serum Total IgE and Cell-Mediated Immunity in Patients with Hodgkin’s Disease

Cited by 9 publications

References 8 publications

Immunoglobulin E Levels and Risk of Lymphoma in a Case-Control Study in Spain

Immunoglobulin E Levels and Risk of Lymphoma in a Case-Control Study in Spain

Levels of certain tumor markers as differential factors between bilharzial and non-biharzial bladder cancer among Egyptian patients

The effect of anti-mu suppression of gammaM and gammaG on the production of gammaE.

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