Relationship of serum vitamin D, D-dimer and uric acid levels with attacks in children with familial Mediterranean fever

Ates, Belen; Sazak, Soner; Türkmenoğlu, Yelda; İrdem, Ahmet; Dursun, Hasan

doi:10.1016/j.ejr.2022.03.004

Cited by 6 publications

(5 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In agreement with our findings, a previous study in Iranian patients showed that vitamin D intake lower than 25 ng/ml (66). Some studies showed that higher levels of vitamin D were associated with lower levels of D-dimer and thrombotic complications (67,68). Hence, vitamin D may regulate thrombotic pathways (69).…”

Section: Discussionsupporting

confidence: 92%

“…Additionally, vitamin D3 can control the cytokine storm by downregulating the release of inflammatory cytokines, such as TNF-alpha and Interleukin 6 ( 66 ). Some studies showed that higher levels of vitamin D were associated with lower levels of D-dimer and thrombotic complications ( 67 , 68 ). Hence, vitamin D may regulate thrombotic pathways ( 69 ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Association between dietary antioxidant quality score and severity of coronavirus infection: a case–control study

et al. 2023

View full text Add to dashboard Cite

The purpose of this study was to examine the association between the dietary antioxidant quality score (DAQS) and the severity of Coronavirus disease 2019 (COVID-19). The present case–control study was carried out on 295 patients diagnosed with COVID-19 (≥18 years old), including 104 critical patients (Intensive care unit [ICU] admission) and 191 COVID-19 patients without severe complications (Non-intensive care unit [Non-ICU] patients) as cases. Dietary intake was assessed by a 147-item, semi-quantitative food frequency questionnaire (FFQ). Logistic regression was performed to calculate the odds ratio (OR) and 95% confidence interval (CI) for the considered risk factors. Our outcomes (after multivariate adjustment) suggested that higher adherence to DAQS was significantly associated with a decreased risk of COVID-19 infection severity (OR = 0.12; 95% CI: 0.04–0.29, p < 0.001). Similar results were seen when analyzed by sex [men (OR = 0.02; 95% CI: 0.002–0.15, p < 0.001) and women (OR = 0.21; 95% CI: 0.06–0.68, p = 0.012)]. A significant association between vitamin D3 intake and decreased risk of COVID-19 severity (OR = 0.91; 95% CI: 0.89–0.94, p < 0.001) was also observed. Moreover, multivariate results revealed that there were no significant associations between vitamin C (OR = 1.00; 95% CI: 0.99–1.00, p = 0.067), vitamin E (OR = 0.98; 95% CI: 0.86–1.11, p = 0.798), zinc (OR = 1.02; 95% CI: 0.86–1.20, p = 0.805), and selenium (OR = 0.99; 95% CI: 0.99–1.00, p = 0.077) intakes with the risk of COVID-19 severity. However, subgroup analyses by sex suggested a significant association between vitamin C intake and the risk of COVID-19 infection severity in women (OR = 1.00; 95% CI: 1.00–1.00, p = 0.028). Our findings showed a negative association between DAQS adherence and the risk of COVID-19 infection severity. Our results may be used to develop potential dietary therapies to decrease COVID-19 severity.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Association between dietary antioxidant quality score and severity of coronavirus infection: a case–control study

et al. 2023

View full text Add to dashboard Cite

show abstract

“…54 Notably, statistically significant deviations in uric acid levels came to light specifically among patients presenting with fever. This observation aligns with established clinical knowledge, 55 undergoing febrile states due to chronic or reactive inflammatory conditions often display fluctuations in this specific marker. Uric acid, which results from purine metabolism, tends to surge during instances of inflammation.…”

Section: Discussionsupporting

confidence: 90%

Evaluation of renal markers and liver enzymes in patients infected with the Chikungunya virus

Soares,

de Lima Neto,

Pour

et al. 2023

Journal of Medical Virology

View full text Add to dashboard Cite

Chikungunya virus (CHIKV) is an arbovirus (Togaviridae family, Alphavirus genus) that was first identified in 1953 in Tanzania. In 2014, the Asian and East/Central/South/African (ECSA) genotypes were identified in Brazil, although the genotype that spread the most in the following years across the Brazilian territory was the ECSA. The clinical symptoms associated with the infection caused by CHIKV include mainly fever, myalgia, headache, and arthralgia. In infections caused by other arboviruses (such as the ones caused by Dengue and West Nile viruses), changes in biochemical markers are often observed. This study aims to evaluate the biochemical markers profile of kidney and liver injury in acute patients infected with CHIKV. Two groups of correlations were found between the variables analyzed, namely, one between liver enzymes (r = 0.91), and another for kidney markers (r = 0.54–0.66). A significant elevation in the percentage of altered creatinine in CHIKV‐infected patients was observed, followed by uric acid and AST. Altogether, in 8 different comparisons, it was possible to observe statistically significant differences between the levels of the markers when compared to the manifestation of symptoms (presence and absence). These noticeable changes in marker measurements could potentially be connected to the range of clinical symptoms seen in the disease.

show abstract

“…In one study, there was no statistically significant difference in serum uric acid levels between FMF patients with and without an attack, even though uric acid levels were higher in patients with FMF than in healthy controls (19). Another study that compared serum uric acid levels in pediatric FMF patients during the attack period and FMF patients during the attack-free period showed that serum uric acid levels were higher during the attack period (20). Previous research in adults found that SUA levels were higher in FMF patients with metabolic syndrome (21); in contrast, our study did not find a correlation between SUA levels and BMI Z score among children with FMF.…”

Section: Discussionmentioning

confidence: 98%

Serum Uric Acid Level Among Children with Familial Mediterranean Fever

Marzouk,

Atef,

El-Khity

et al. 2024

Pediatric Sciences Journal

View full text Add to dashboard Cite

Background: Familial Mediterranean fever (FMF) is the most frequent form of inherited periodic fever syndromes. It is caused by a mutation in the MEFV gene and is transmitted by autosomal recessive mode. It is marked by recurring fever episodes with a range of symptoms due to inflammation in the pleura, synovium, and peritoneum. In FMF patients, subclinical inflammation frequently persists throughout the attack-free periods. Uric acid is a product of purine nucleotides catabolism. It is elevated in tissue damage. Aim of the work:To assess uric acid levels and glomerular filtration rate (GFR) in children with FMF during the attack-free period. Subjects and Methods: This cross-sectional study assessed uric acid levels and GFR in 40 children with FMF during the attack-free period. They were enrolled from the

show abstract

Relationship of serum vitamin D, D-dimer and uric acid levels with attacks in children with familial Mediterranean fever

Cited by 6 publications

References 33 publications

Association between dietary antioxidant quality score and severity of coronavirus infection: a case–control study

Association between dietary antioxidant quality score and severity of coronavirus infection: a case–control study

Evaluation of renal markers and liver enzymes in patients infected with the Chikungunya virus

Serum Uric Acid Level Among Children with Familial Mediterranean Fever

Contact Info

Product

Resources

About