Relationship of social support to stress responses and immune function in healthy and asthmatic adolescents

Kang, Duck Hee; Coe, Christopher L.; Karaszewski, Joseph W.; McCarthy, Donna O.

doi:10.1002/(sici)1098-240x(199804)21:2<117::aid-nur3>3.0.co;2-m

Cited by 43 publications

(17 citation statements)

References 37 publications

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“…Skewed Th1/Th2 ratio and reduced NK cell numbers were detected in atopic rather than normal students in association with large exams indicating that atopics may be more strongly affected by stress than others (Höglund et al, 2006;Marshall et al, 2000). Reduction in NK cells was also detected in nursing students in response to academic exam whether healthy or asthmatic (Kang et al, 1988).…”

Section: Introductionsupporting

confidence: 77%

“…This result goes in hand with previous reports that described low count and or cytotoxicity of NK cells during stress (Bellingrath et al, 2010;Nakata et al, 2011;Duggal et al, 2015). Similarly, a decrease in NK cell number was reported in allergic students in context to exam stress (Kang et al, 1988;Höglund et al, 2006). Also the psychological stress that accompany the experience of diagnostic breast biopsy was accompanied by decrease in NK cell activity that lasts up to one month after the procedure (WitekJanusek et al, 2007) and similar results were detected in geriatric age group who are subjected to psychological stress after hip fracture (Duggal et al, 2005) .…”

Section: Discussionmentioning

confidence: 99%

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Chronic Mental Stress Induces Reversible Reduction of Natural Killer Cells and CD56<sup>dim </sup>Subpopulation

Ismail¹

2017

American Journal of Immunology

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Generally, studying to be a health care provider is a stressful and demanding field and the students have to face many stressors that may affect their general health status including the immune system. This work aimed at studying the effect of prolonged naturalistic life-stress exposure on the percentage of peripheral blood T-lymphocytes and Natural Killer (NK) cells in female laboratory medicine students. 52 peripheral blood samples in the last week of the final written exam (stress time point) and 27 samples after 12 weeks rest (control) were withdrawn and analyzed by flow cytometry. At the stress time point, there was a significant high T helper cells percentage with elevation of T helper/T cytotoxic ratio, P value <0.001. Also, significant low percentages of NK cells and CD56 dim together with high CD56 bright subpopoulations were detected, P value <0.001. Lymphocyte analysis of the subgroup that had an attach of common cold (34.6%) revealed significant reduction in the number of T cytotoxic and NK cells, P values 0.042 and 0.001 respectively. This study concluded that in humans, naturalistic chronic stress as expressed in academic exams has the potential to negatively affect the immune system, but normality is regained after sufficient stress relieve measures. Replication in larger and more diverse sample populations with inclusion of males for comparison is required, Also assessments of NK cell cytotoxicity and T helper cell subsets especially T regulatory cells are required for future studies.

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Section: Introductionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Chronic Mental Stress Induces Reversible Reduction of Natural Killer Cells and CD56<sup>dim </sup>Subpopulation

Ismail¹

2017

American Journal of Immunology

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“…Loneliness affects NK cell activity not only in psychiatric patients (Kiecolt-Glaser et al 1984b), but also in young and healthy medical students indicating general importance of social relationships for individuals' wellbeing (Kang et al 1998;Kiecolt-Glaser et al 1984a). Marital quality and recent separation among young women were associated with depressive symptoms and poorer immune function, seen through poorer proliferation of lymphocytes after stimulation with different mitogens (concavalin A and phytohemagglutinin) (Kiecolt-Glaser et al 1987).…”

Section: Psychological Stress and Immunitymentioning

confidence: 99%

Stress, ageing and their influence on functional, cellular and molecular aspects of the immune system

Vitlić

Lord

Phillips

2014

AGE

103

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The immune response is essential for keeping an organism healthy and for defending it from different types of pathogens. It is a complex system that consists of a large number of components performing different functions. The adequate and controlled interaction between these components is necessary for a robust and strong immune response. There are, however, many factors that interfere with the way the immune response functions. Stress and ageing now consistently appear in the literature as factors that act upon the immune system in the way that is often damaging. This review focuses on the role of stress and ageing in altering the robustness of the immune response first separately, and then simultaneously, discussing the effects that emerge from their interplay. The special focus is on the psychological stress and the impact that it has at different levels, from the whole system to the individual molecules, resulting in consequences for physical health.

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“…Cells were resuspended at the final concentration of 2×10 6 cells/ml with complete medium (RPMI 1640 supplemented with HEPES 25 mM, L-glutamine 2 mM, Penicillin 50 unit and Streptomycin 50µg/ml). The cell viability was determined using trypan blue staining, which is known to yield >98% viability of PBMCs 42,43…”

Section: Methodsmentioning

confidence: 99%

Objective and Subjective Breast Cancer Risk

2010

Self Cite

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Background Breast cancer (BC) risk, based on either known risk factors (objective) or self-assessment (subjective), may influence natural killer cell activity (NKCA) directly or through psychological distress. Objective The main objective of this study was to examine the relationships of objective and subjective BC risk with NKCA and a mediating role of psychological distress in a community sample of healthy women. Methods In a cross-sectional descriptive study, a convenience sample of 117 healthy women (mean age 36.5 years) completed questionnaires for BC risk and psychological distress and provided blood for NKCA measurement. Results Objective and subjective BC risk were positively correlated (p < .001). Regression analyses revealed that objective BC risk had a significant negative relationship with NKCA at the 12.5:1 effector-to-target (E:T) cell ratio (p = .011), whereas subjective risk was not associated with NKCA at any E:T cell ratio tested. Only subjective risk had a positive association with both BC-specific (p = .002) and general (p < .001) psychological distress. Psychological distress failed to mediate the relationship between subjective risk and NKCA. Conclusions Objective BC risk had a limited but significant relationship with NKCA. Subjective risk was highly associated with psychological distress but was not associated with NKCA. Implications for Practice Despite the limited relationships between BC risk and NKCA, the impact of BC risk on other tumor defense mechanisms needs to be further explored. Collective findings in this area will suggest early preventive strategies for monitoring BC risk and maintaining better tumor defense in healthy women.

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Relationship of social support to stress responses and immune function in healthy and asthmatic adolescents

Cited by 43 publications

References 37 publications

Chronic Mental Stress Induces Reversible Reduction of Natural Killer Cells and CD56<sup>dim </sup>Subpopulation

Chronic Mental Stress Induces Reversible Reduction of Natural Killer Cells and CD56<sup>dim </sup>Subpopulation

Stress, ageing and their influence on functional, cellular and molecular aspects of the immune system

Objective and Subjective Breast Cancer Risk

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