Relationship of solar keratosis and history of skin cancer to objective measures of actinic skin damage

Holman, Cheryl; Armstrong, Bruce K.; Evans, P. R.; Lumsden, G. J.; Dallimore, K. J.; Meehan, C.; Beagley, J.; Gibson, I. M.

doi:10.1111/j.1365-2133.1984.tb07458.x

Cited by 103 publications

(90 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…No consistent trends are seen for either the protective effect of increased average sun exposure of the two most recent time periods; however, for the 11 to 20 years prior to diagnosis was seen to be strongest time period 11 to 20 years prior to diagnosis, the risk ap-for subjects 20 sunburn with blistering (OR = 0.79), whereas for poor tanners there was an almost 3-fold risk (OR = 2.9, p < 0.01) associated with this type of exposure. Addition of interactive effects between tanning ability and severe sunburn with blistering to the multiple logistic analysis was significant (chi-square = 5.6, 1 df, p < 0.05).…”

Section: Consideration Of Potential Confounding Variablesmentioning

confidence: 89%

“…Other authors have also attempted to distinguish between total cumulative and intermittent sun exposure (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)20 (6,8,9). It is important to note that consistent patterns across several exposure variables and among levels of exposure are required if one is to guard against the fallacies inherent in unrestrained subgroup analysis (21).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Sun exposure and malignant melanoma among susceptible individuals.

Dubin

Moseson

Pasternack

1989

Environ Health Perspect

View full text Add to dashboard Cite

The purpose of this case-control study was to identify susceptible subgroups, primarily based on pigmentary characteristics, at higher risk of developing melanoma when exposed to the sun. The study group, which was interviewed from 1979 to 1982, consisted of 289 consecutive patients with melanoma and 527 randomly selected controls without cancer. In general, the risk of melanoma associated with sun exposure was greater for individuals expected to be susceptible on the basis of poor ability to tan, but not other pigmentary traits. There were, in addition, some noteworthy interactions between age and sun exposure.Among subjects with poor tanning ability, the risk of melanoma associated with outdoor occupation was more than 3-fold [odds ratio (OR) = 3.31 compared to indoor occupation. In contrast, the analogous OR was much less elevated among subjects with a good ability to tan (OR = 1.5). Mixed indoor and outdoor job exposure was protective among good tanners (OR = 0.80), but not among poor tanners (OR = 1.5). A similar pattern was seen for recreational sun exposure and, when applying multiple logistic regression, for the patient's overall subjective assessment of his lifetime sun exposure. However, quantitative assessment of average hours of sun exposure did not prove to be a good indicator of melanoma risk, even among susceptible individuals. A history of severe sunburn with blistering was associated with nearly 3-fold risk among poor tanners (OR = 2.9) but was protective among good tanners (OR = 0.79). A history of nonmelanoma skin cancer or solar keratosis was a very strong risk factor (OR = 7.3), which, however, did not significantly differ in magnitude among susceptibility subgroups.

show abstract

Section: Consideration Of Potential Confounding Variablesmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Sun exposure and malignant melanoma among susceptible individuals.

Dubin

Moseson

Pasternack

1989

Environ Health Perspect

View full text Add to dashboard Cite

show abstract

“…There have been epidemiological studies to establish the relationship between cumulative solar exposure and skin cancer such as SCC and BCC [23, 24, 25, 26]. Wulf et al [11]experimentally induced SCC by using a narrow-band UV light in hairless mice.…”

Section: Discussionmentioning

confidence: 99%

Solar Damage in Skin Tumors: Quantification of Elastotic Material

Moon

Oh²

2001

Dermatology

View full text Add to dashboard Cite

Background: The elastotic changes of the dermis are thought to be the primary indicator of the cumulative sun exposure of the dermis. The changes of elastotic material have been evaluated by several previous methods, but these did not quantitatively measure the amount of elastic tissue. Objective: The purpose of this study was to quantify dermal elastosis and to assess the significance of sun exposure in the pathogenesis of nonmelanomatous skin tumors such as basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and Bowen’s disease (BD). Methods: Ninety-nine sections from biopsy specimens of histopathologically proven BCC, SCC and BD were stained with Verhoeff-van Gieson stains. We studied the amount of elastotic material adjacent to the tumor by image analysis. Results: There was a 3- to 4-fold increase in the amount of elastotic material in BCC and SCC compared to the sun-exposed skin of normal controls (p < 0.0001). The amount of elastotic material was increased 1.3 times in BD as compared with the nonexposed skins of normal controls (p < 0.01). Conclusion: We demonstrated a quantitative relationship between cumulative solar exposure and skin cancer such as SCC, BCC and BD.

show abstract

“…Holman et al 19 , in a study in a community of the Australian West, detected in solar keratosis 17% of men and 8% of women below 40 years by age. These investigators stated that an increasing number of young people are being seen with signs of changes provoked by solar radiation and consequently with skin cancer.…”

Section: Skin Alterations Attributable To Solar Radiationmentioning

confidence: 99%

Risk factors for basal cell carcinoma: a case-control study

1995

View full text Add to dashboard Cite

A controlled trial was performed with the purpose of investigating which factors could be considered of significant risk for the development of basal cell carcinoma. A total of 259 cases of basal cell carcinoma diagnosed from July 1991 to July 1992 were compared with 518 controls matched for age and sex. All subjects in both groups were white. Protocol data were submitted to statistical analysis by the chi-square test and by multiple conditional logistic regression analysis and the following conclusions were reached: 1) light skin color (types I and II of the Fitzpatrick classification), odds ratio of 2.8; outdoor work under constant sunlight, odds ratio of 5.0; the presence of actinic lesions due to exposure to the sun, odds ratio of 4.9, are risk factors perse. 2) Type III skin in the Fitzpatrick classification only represents a risk factor when the patient reports a history of intense sunburns, but not in the absence of such a history. 3) Sunburns per se do not represent a risk factor althorig the point made in item 2 of these conclusions is valid. 4) Other suspected risk factors whose significance was not confirmed by multiple conditioned logistic regression analysis were: residence in rural areas, light eyes and blond hair color, extent of the awareness of the "sun x skin cancer" relationship, familial occurrence of skin cancer, excessive exposure to the sun, and freckles appearing in childhood.Carcinoma, basal cell, epidemiology.Risk factors.

show abstract

Relationship of solar keratosis and history of skin cancer to objective measures of actinic skin damage

Cited by 103 publications

References 13 publications

Sun exposure and malignant melanoma among susceptible individuals.

Sun exposure and malignant melanoma among susceptible individuals.

Solar Damage in Skin Tumors: Quantification of Elastotic Material

Risk factors for basal cell carcinoma: a case-control study

Contact Info

Product

Resources

About