Relationship of Structural and Tissue Components of Full-Layer Skin Wound and Mathematical Modeling of the Healing Process

Шестакова, Валерия Геннадьевна; Nikityuk, D. B.; Bazhenov, D. V.; Банин, В. В.

doi:10.1007/s10517-020-04896-5

Cited by 3 publications

(2 citation statements)

References 2 publications

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“…Formation of the granulation tissue appeared to proceed more slowly than in normal open wounds (Gal et al, 2008;Shestakova et al, 2020). However, the newly formed collagen was similar to normal collagen of intact skin (Stern et al, 1990;Muangman et al, 2006).…”

Section: Discussionmentioning

confidence: 87%

Early Changes during Skin Repair Using Tissue-Engineered Dermal Template in a Full-Thickness Burn

Gál,

Fröhlichová,

Čoma

et al. 2020

Fol. Biol.

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Rapid wound closure in extensively burned patients has remained one of the major unresolved issues of medicine. Integra® is the most widely established artificial skin, which is composed of a porous matrix of cross-linked bovine collagen and chondroitin 6-sulphate covered by a semi-permeable silicone layer. We present here a (immuno)histological study of a severely burned patient with a full-thickness burn treated with a tissue-engineered dermal template (Integra®) and split-thickness skin graft-based protocol. Immunohistochemical investigation of the artificial dermis revealed that immune cell infiltration reached its peak on day 10. Tissue immunophenotyping found an increase in CD3+ cells over the course of the study as well as CD4 and CD8 positivity on day 40, indicating remaining T-cell subpopulations. We observed weak/no infiltration of NK cells (CD56+). In conclusion, the use of bi-layer Integra® represents a feasible and safe procedure resulting in formation of non-irritating dermal substitutes.

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Section: Discussionmentioning

confidence: 87%

Early Changes during Skin Repair Using Tissue-Engineered Dermal Template in a Full-Thickness Burn

Gál,

Fröhlichová,

Čoma

et al. 2020

Fol. Biol.

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“…Existing research data show that chronic wounds contain aging keratinocytes, endothelial cells, fibroblasts, and macrophages [35]. Vascular regeneration was slow [36], collagen deposition was delayed, and granulation tissue grew slowly [37].…”

Section: Histopathological Resultsmentioning

confidence: 99%

Preparation of W/O Hypaphorine–Chitosan Nanoparticles and Its Application on Promoting Chronic Wound Healing via Alleviating Inflammation Block

Zhu

et al. 2021

Nanomaterials

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Chronic wound repair is a common complication in patients with diabetes mellitus, which causes a heavy burden on social medical resources and the economy. Hypaphorine (HYP) has good anti-inflammatory effect, and chitosan (CS) is used in the treatment of wounds because of its good antibacterial effect. The purpose of this research was to investigate the role and mechanism of HYP-nano-microspheres in the treatment of wounds for diabetic rats. The morphology of HYP-NPS was observed by transmission electron microscopy (TEM). RAW 264.7 macrophages were used to assess the bio-compatibility of HYP-NPS. A full-thickness dermal wound in a diabetic rat model was performed to evaluate the wound healing function of HYP-NPS. The results revealed that HYP-NPS nanoparticles were spherical with an average diameter of approximately 50 nm. The cell experiments hinted that HYP-NPS had the potential as a trauma material. The wound test in diabetic rats indicated that HYP-NPS fostered the healing of chronic wounds. The mechanism was through down-regulating the expression of pro-inflammatory cytokines IL-1β and TNF-α in the skin of the wound, and accelerating the transition of chronic wound from inflammation to tissue regeneration. These results indicate that HYP-NPS has a good application prospect in the treatment of chronic wounds.

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Nanofibrous dressing with drug/electroactivity synergistic effect for wound healing

Chen,

Jia,

Wang

et al. 2024

Chemical Engineering Journal

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Relationship of Structural and Tissue Components of Full-Layer Skin Wound and Mathematical Modeling of the Healing Process

Cited by 3 publications

References 2 publications

Early Changes during Skin Repair Using Tissue-Engineered Dermal Template in a Full-Thickness Burn

Early Changes during Skin Repair Using Tissue-Engineered Dermal Template in a Full-Thickness Burn

Preparation of W/O Hypaphorine–Chitosan Nanoparticles and Its Application on Promoting Chronic Wound Healing via Alleviating Inflammation Block

Nanofibrous dressing with drug/electroactivity synergistic effect for wound healing

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