Relationship of Structural Magnetic Resonance Imaging, Magnetic Resonance Perfusion, and Other Disease Factors to Neuropsychological Outcome in Sickle Cell Disease

Grueneich, Royal; Ris, M. Douglas; Ball, William S.; Kalinyak, Karen; Noll, Robert B.; Vannatta, Kathy; Wells, Robert J.

doi:10.1093/jpepsy/jsh012

Cited by 41 publications

(34 citation statements)

References 33 publications

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“…In addition to detrimental effects on general cognitive functioning, SCD has been associated with deficits in specific areas of neurocognitive functioning including executive functioning [1,[9][10][11][12][13][14] and visuo-motor functions [15,16]. Deficits in these two areas are expected, given that silent infarcts commonly occur in frontal lobe white matter, within the border zone between the middle and anterior cerebral artery distribution [17,18].…”

Section: Introductionmentioning

confidence: 99%

“…Although deficits on this neurocognitive domain have been recognized in children with SCD, findings remain inconsistent [1]. Some researchers have reported average motor skills in children with SCD [10,20] while others found clear deficits compared to healthy controls [15,16]. Many studies investigated either visual-spatial or motor skills, but not both [1].…”

Section: Introductionmentioning

confidence: 99%

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Neurocognitive deficits in children with sickle cell disease: a comprehensive profile

Hijmans

Fijnvandraat

Grootenhuis

et al. 2010

Pediatric Blood & Cancer

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BackgroundSickle cell disease (SCD) can lead to profound cerebral damage, associated with neurocognitive deficits. The aim of the current study was to evaluate a broad range of neurocognitive functions in children with SCD compared to a SES‐matched control group, in order to gain more insight into the specific deficits of these patients.MethodsForty‐one children with homozygous SCD (HbSS or HbS‐β0‐thalassemia) and 38 controls were assessed on a comprehensive set of well‐defined and validated measures of neurocognitive functioning. Besides general intelligence, we evaluated executive functioning extensively (including response inhibition, sustained attention, planning, visuo‐spatial working memory, and verbal working memory) as well as visuo‐motor functioning.ResultsSCD was clearly associated with lower IQ scores. More than one in three children with SCD had a Full‐scale IQ below 75. Furthermore, children with SCD showed deficits in visuo‐motor functioning. Some evidence was found for executive dysfunction: Children with SCD displayed poor visuo‐spatial working memory, as well as subtle deficits in sustained attention and planning. No significant differences were found between children with SCD and controls in terms of response inhibition and verbal working memory.ConclusionsChildren with SCD are at increased risk of lower intelligence, visuo‐motor impairments, and executive dysfunction. These neurocognitive deficits may underlie high rates of scholastic impairments in these children. The present findings further illuminate the importance of regular neurocognitive evaluations and future neurocognitive rehabilitation programs for children with SCD. Pediatr Blood Cancer 2011;56:783–788. © 2010 Wiley‐Liss, Inc.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neurocognitive deficits in children with sickle cell disease: a comprehensive profile

Hijmans

Fijnvandraat

Grootenhuis

et al. 2010

Pediatric Blood & Cancer

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“…13 In children with SCA, the association between cerebrovascular lesions and IQ is well established. 5,6,8,9,14,15 However, because a significant proportion of both children and adults with SCA do not have cerebrovascular lesions, 5,13,16 additional CNS factors likely contribute to cognitive dysfunction. Frontal lobe cortical atrophy [17][18][19][20][21] and gray matter growth delays in the basal ganglia and thalamus reported in children and adolescents with SCA [22][23][24] may represent factors contributing to poorer intellectual function in adults with SCA.…”

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confidence: 99%

Neuroimaging abnormalities in adults with sickle cell anemia

Mackin

Insel²,

Truran³

et al. 2014

Neurology

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Objective: This study was conducted to determine the relationship of frontal lobe cortical thickness and basal ganglia volumes to measures of cognition in adults with sickle cell anemia (SCA).Methods: Participants included 120 adults with SCA with no history of neurologic dysfunction and 33 healthy controls (HCs). Participants were enrolled at 12 medical center sites, and raters were blinded to diagnostic group. We hypothesized that individuals with SCA would exhibit reductions in frontal lobe cortex thickness and reduced basal ganglia and thalamus volumes compared with HCs and that these structural brain abnormalities would be associated with measures of cognitive functioning (Wechsler Adult Intelligence Scale, 3rd edition). Results:

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“…The scoring system [16,17] classifies 12 abnormal features by location. Abnormal features include volume loss, leukomalacia/gliosis, other white matter lesion, encephalomalacia, heterotopia, cortical dysplasia, other gray matter lesion, mass lesion, increased or decreased (restricted) diffusion, hemorrhage, and vascular lesion.…”

Section: Mri Scoring Systemmentioning

confidence: 99%

Findings of MR Imaging and it's necessity in Children with First Recognized Seizure: A Tertiary Center Based prospective Cohort Study

Biswas¹,

Mohapatra²,

Mishra³

et al. 2017

IOSR JDMS

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identified in 34 (12%). The most common abnormalities were ventricular enlargement (51%), leukomalacia/gliosis (23%), gray matter lesions such as heterotopias and cortical dysplasia (12%), volume loss (12%), various other white matter lesions (9%), and encephalomalacia (6%). Abnormalities defined as significant, or potentially related to seizures, occurred in 40 (14%). Temporal lobe and hippocampal abnormalities were detected at a higher frequency than in previous studies (13/87

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Relationship of Structural Magnetic Resonance Imaging, Magnetic Resonance Perfusion, and Other Disease Factors to Neuropsychological Outcome in Sickle Cell Disease

Abstract: These results corroborate the high rate of rheologic and vascular pathology in SCD and underscore the importance of representing neuropsychological functioning in multiple ways.

Cited by 41 publications

References 33 publications

Neurocognitive deficits in children with sickle cell disease: a comprehensive profile

Neurocognitive deficits in children with sickle cell disease: a comprehensive profile

Neuroimaging abnormalities in adults with sickle cell anemia

Findings of MR Imaging and it's necessity in Children with First Recognized Seizure: A Tertiary Center Based prospective Cohort Study

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