Relationship of subclinical hypothyroidism and obesity in polycystic ovarian syndrome patients

Nayak, Prasant; Mitra, Subarna; Sahoo, Jayaprakash; Mahapatra, Eli; Agrawal, Sarita; Lone, Zamir

doi:10.4103/jfmpc.jfmpc_654_19

Cited by 10 publications

(10 citation statements)

References 24 publications

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“…Glintborg, D. et al found an increased risk of hypothyroidism, Graves' disease, goiter, and thyroiditis in the Danish population with PCOS [3]. Similar ndings have been found in many studies [4][5][6][7][8][9]. A recent large sample meta-analysis study [10,11] also revealed a strong association between thyroid disease and PCOS.…”

Section: Introductionsupporting

confidence: 62%

“…Singh, J. et al found multiple causes of hypothyroidism leading to the development of PCOS, among which, there was a signi cant relationship between the incidence of polycystic ovary syndrome and thyroiditis [17]. A study by Nayak, P. K. et al found that patients with PCOS were more often associated with subclinical hypothyroidism [7]. Raj, D found similar ndings in an Asian population where SCH was more prevalent in patients with PCOS (43.5% vs. 20.5%; P < 0.001) [18].…”

Section: Discussionmentioning

confidence: 99%

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The influence of hypothyroidism, hyperthyroidism, autoimmune thyroiditis and thyroid cancer on the risk of polycystic ovary syndrome: a Mendelian Randomization study

2022

Preprint

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Background Observational studies have found a correlation between thyroid diseases and polycystic ovary syndrome (PCOS). However, their causal relationship remains uncertain. Our purpose was to investigate the causal relationship between four common thyroid diseases (hypothyroidism, hyperthyroidism, autoimmune thyroiditis, thyroid cancer) and PCOS risk. Methods In this study, using the Mendelian randomization (MR) approach, we obtained single nucleotide polymorphisms (SNPs) from the genome-wide association study (GWAS) database as instrumental variables (IVs) and used inverse variance weighting (IVW) to explore the causal relationship between four common thyroid diseases and PCOS. Results We found a significant causal association between hypothyroidism and increased risk of PCOS [OR = 34.90, 95% CI: (1.68, 724.53), P = 0.02]. However, hyperthyroidism, autoimmune thyroiditis, thyroid cancer has no significant causal association with PCOS. Conclusion Hypothyroidism may increase the risk of PCOS. Hyperthyroidism, autoimmune thyroiditis, thyroid cancer has no significant causal association with PCOS.

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Section: Introductionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

The influence of hypothyroidism, hyperthyroidism, autoimmune thyroiditis and thyroid cancer on the risk of polycystic ovary syndrome: a Mendelian Randomization study

2022

Preprint

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“…When TSH binds to the receptor in adipocytes, it stimulates interleukin-6 release from adipocytes and then mediates proliferation, differentiation, and leptin secretion of preadipocytes and adipocytes [16]. The growing evidence also suggests an association of altered thyroid function and obesity causes a lasting state of low-grade inflammation, while Nayak et al found no association between obesity and subclinical hypothyroidism among PCOS patients [17][18].…”

Section: Discussionmentioning

confidence: 99%

Correlation of Subclinical Hypothyroidism With Polycystic Ovary Syndrome (PCOS)

Fatima

Amjad

Ali

et al. 2020

Cureus

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Aim The correlation of subclinical hypothyroidism (SCH) and polycystic ovary syndrome (PCOS) is a still insufficiently explored entity. The aim of this study was to determine the correlation between SCH and PCOS along with the impact of SCH on metabolic and hormonal parameters in women with PCOS. Methodology This cross-sectional study was conducted at the Gynecology Outpatient Department of Ziauddin Hospital Kemari, Karachi, Pakistan, from June 2019 to December 2019. A total of 90 diagnosed cases of PCOS were enrolled in the study. A non-probability consecutive sampling technique was used. After taking informed consent, participants were evaluated through clinical interviews, a questionnaire, and anthropometric measurements. The participants underwent the following assessments, i.e., transabdominal ultrasonography, hormonal profile (free testosterone, follicle-stimulating hormone, luteinizing hormone), and fasting blood sugar. Participants were divided into two groups based on thyroid-stimulating hormone (TSH) into the euthyroid group and subclinical hypothyroid (SCH) group. The Mann-Whitney test was used for comparing the two groups. Results Our results showed a significant difference in weight, body mass index (BMI), insulin, homeostatic model assessment of insulin resistance (HOMA-IR), and TSH were found in the SCH group as compared to the euthyroid group. A significant correlation of TSH with waist-hip ratio (WHR), weight, body mass index (BMI), insulin, and the homeostatic model assessment of insulin resistance (HOMA-IR) in PCOS patients. Conclusion This study showed a significant correlation of subclinical hypothyroidism with polycystic ovary syndrome. We found subclinical hypothyroidism may aggravate the insulin resistance; therefore, PCOS patients must be screened with a thyroid profile.

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“…Various studies have shown a correlation between hypothyroidism and higher prevalence of obesity [ 35 , 36 ]. Major weight gain has been associated with even a mild to moderate decrease in thyroid function.…”

Section: Discussionmentioning

confidence: 99%

Effect of Hypovitaminosis D on Lipid Profile in Hypothyroid Patients in Saudi Arabia

Alsamghan

Alsaleem

Alzahrani

et al. 2020

Oxidative Medicine and Cellular Longevity

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Background. Hypothyroidism is believed to be associated with dyslipidemia and is considered a risk factor for the development of atherosclerotic cardiovascular diseases (ASCVD). Vitamin D, due to its steroid hormone action, retains cell function and controls the metabolism of lipids. Therefore, the present study was carried out to show the association of the risk factors of ASCVD and deficiency of thyroid hormones and vitamin D levels since no previous studies have been performed on Saudi patients before. Methodology. A retrospective cohort study was carried out on 400 hypothyroid patients. Medical records of those patients were followed up and were classified as normal and hypothyroid patients according to their thyroid-stimulating hormone levels. TSH, vitamin D, and lipid profiles were determined using the ELISA technique. Result. Total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels were significantly higher in hypothyroid patients than those in the normal group. We have found a significant correlation between TSH levels and the risk factors of ASCVD (total cholesterol, triglycerides, and LDL-C). Moreover, a significant correlation between vitamin D levels and the risk factors of ASCVD (total cholesterol, triglycerides, and LDL-C) has been found. In addition, there is a correlation between deficiency of Vit D and low-TSH levels (95% CI 1.092–4.05) indicating a higher risk for the development of ASCVD among those patients. Conclusion. Hypothyroid and vitamin D-deficient patients must be screened regularly at an early stage to predict and also to prevent cardiovascular diseases. Moreover, an adequate supply of vitamin D and TH should be given to those patients to prevent cardiovascular diseases at an early stage.

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Relationship of subclinical hypothyroidism and obesity in polycystic ovarian syndrome patients

Cited by 10 publications

References 24 publications

The influence of hypothyroidism, hyperthyroidism, autoimmune thyroiditis and thyroid cancer on the risk of polycystic ovary syndrome: a Mendelian Randomization study

The influence of hypothyroidism, hyperthyroidism, autoimmune thyroiditis and thyroid cancer on the risk of polycystic ovary syndrome: a Mendelian Randomization study

Correlation of Subclinical Hypothyroidism With Polycystic Ovary Syndrome (PCOS)

Effect of Hypovitaminosis D on Lipid Profile in Hypothyroid Patients in Saudi Arabia

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