Relationship of Temporal Lobe Seizures to Sleep and Arousal: A Combined Scalp-Intracranial Electrode Study

Malow, Beth A.; Bowes, Robert; Ross, Donald A.

doi:10.1093/sleep/23.2.1j

Cited by 49 publications

(48 citation statements)

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“…Comparing with our results, in a retrospective study most of the sleep related temporal lobe seizures preceded arousals but that study examined patients with invasive recordings [12]. Scalp EEG is difficult to use for the exact definition of ictal onsets; time onset of seizures can be earlier [25].…”

Section: Discussionsupporting

confidence: 43%

“…Scalp EEG is difficult to use for the exact definition of ictal onsets; time onset of seizures can be earlier [25]. Depth or subdural electrodes covering the epileptogenic area can show the real time onset and localization of ictal changes [12]. In the study by Malow et al, 60 temporal lobe onset seizures preceded clinical arousals from sleep and 7 seizures followed arousals [12].…”

Section: Discussionmentioning

confidence: 99%

“…Depth or subdural electrodes covering the epileptogenic area can show the real time onset and localization of ictal changes [12]. In the study by Malow et al, 60 temporal lobe onset seizures preceded clinical arousals from sleep and 7 seizures followed arousals [12]. There is no information about FLE patients with intracranial EEG recordings.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, in patients with focal epilepsy, 83% of temporal lobe seizures were recorded during times of mini-arousals in a cycling alternating pattern (CAP) [9,10]. Although there are suggestions about seizures in mesial TLE occurring during sleep, related to awakening [11], intracranial recordings showed that arousal actually follows the onset of the seizure rather than preceding it [12]. A close relationship between frontal lobe related events and the EEG synchronized patterns of CAP has also been reported [13].…”

Section: Introductionmentioning

confidence: 99%

“…Our main aim, however, was to determine the time between onset of seizures and awakening. There are a few studies about relationship between arousal-awakening and seizures [10,[12][13][14]. But to the best of our knowledge there is no study about effect of partial seizures, including both FLE and TLE on awakening.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Temporal relationship between awakening and seizure onset in nocturnal partial seizures

Yıldız¹,

Tezer²,

Saygı

2012

Journal of the Neurological Sciences

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Section: Discussionsupporting

confidence: 43%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Temporal relationship between awakening and seizure onset in nocturnal partial seizures

Yıldız¹,

Tezer²,

Saygı

2012

Journal of the Neurological Sciences

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Paradoxical effects of optogenetic stimulation in mesial temporal lobe epilepsy

Lévesque

Chen

Etter

et al. 2019

Annals of Neurology

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Objective: To establish the effects induced by long-term, unilateral stimulation of parvalbumin (PV)-positive interneurons on seizures, interictal spikes, and high-frequency oscillations (80-500Hz) occurring after pilocarpine-induced status epilepticus (SE)-a proven model of mesial temporal lobe epilepsy (MTLE)-in transgenic mice expressing or not expressing ChR2. Methods: PV-ChR2 (n = 6) and PV-Cre (n = 6) mice were treated with pilocarpine to induce SE. Three hours after SE onset, unilateral optogenetic stimulation (450nm, 25mW, 20-millisecond pulses delivered at 8Hz for 30 seconds every 2 minutes) of CA3 PV-positive interneurons was implemented for 14 continuous days in both groups. Results: Rates of seizures (p < 0.01), interictal spikes (p < 0.001), and interictal spikes with fast ripples (250-500Hz) (p < 0.001) were lower in PV-ChR2 than in PV-Cre mice. Ripples (80-200Hz) occurring outside of interictal spikes had higher rates in the PV-ChR2 group (p < 0.01), whereas isolated fast ripples had lower rates (p < 0.01). However, seizure probability was higher during optogenetic stimulation in PV-ChR2 compared to PV-Cre animals (p < 0.05). Interpretation: Our findings show that the unilateral activation of CA3 PV-positive interneurons exerts anti-ictogenic effects associated with decreased rates of interictal spikes and fast ripples in this MTLE model. However, PV-positive interneuron stimulation can paradoxically trigger seizures in epileptic animals, supporting the notion that γ-aminobutyric acid type A signaling can also initiate ictogenesis. ANN NEUROL 2019;86:714-728 View this article online at wileyonlinelibrary.com.

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Sleep Disruption in Epilepsy: Ictal and Interictal Epileptic Activity Matter

Peter‐Derex

Klimeš

Latreille

et al. 2020

Annals of Neurology

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Objective: Disturbed sleep is common in epilepsy. The direct influence of nocturnal epileptic activity on sleep fragmentation remains poorly understood. Stereo-electroencephalography paired with polysomnography is the ideal tool to study this relationship. We investigated whether sleep-related epileptic activity is associated with sleep disruption. Methods: We visually marked sleep stages, arousals, seizures, and epileptic bursts in 36 patients with focal drugresistant epilepsy who underwent combined stereo-electroencephalography/polysomnography during presurgical evaluation. Epileptic spikes were detected automatically. Spike and burst indices (n/sec/channel) were computed across four 3-second time windows (baseline sleep, pre-arousal, arousal, and post-arousal). Sleep stage and anatomic localization were tested as modulating factors. We assessed the intra-arousal dynamics of spikes and their relationship with the slow wave component of non-rapid eye-movement sleep (NR) arousals. Results: The vast majority of sleep-related seizures (82.4%; 76.5% asymptomatic) were followed by awakenings or arousals. The epileptic burst index increased significantly before arousals as compared to baseline and postarousal, irrespective of sleep stage or brain area. A similar pre-arousal increase was observed for the spike index in NR stage 2 and rapid eye-movement sleep. In addition, the spike index increased during the arousal itself in neocortical channels, and was strongly correlated with the slow wave component of NR arousals (r = 0.99, p < 0.0001). Interpretation: Sleep fragmentation in focal drug-resistant epilepsy is associated with ictal and interictal epileptic activity. The increase in interictal epileptic activity before arousals suggests its participation in sleep disruption. An additional increase in the spike rate during arousals may result from a sleep-wake boundary instability, suggesting a bidirectional relationship.

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Relationship of Temporal Lobe Seizures to Sleep and Arousal: A Combined Scalp-Intracranial Electrode Study

Cited by 49 publications

References 0 publications

Temporal relationship between awakening and seizure onset in nocturnal partial seizures

Temporal relationship between awakening and seizure onset in nocturnal partial seizures

Paradoxical effects of optogenetic stimulation in mesial temporal lobe epilepsy

Sleep Disruption in Epilepsy: Ictal and Interictal Epileptic Activity Matter

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