Relationship of Torch Profile in First Trimester Spontaneous Miscarriage

Abstract

Background TORCH is a group of organisms like Toxoplasma, Rubella, Cytomegalo virus and Herpes simplex virus. These groups of organisms causing infections in pregnant lady leads to various degree of adverse pregnancy outcomes in the form of spontaneous abortion, preterm delivery, intrauterine growth restriction, severe congenital defect with syndromic babies. So, to observe the relationship of TORCH infection in first trimester spontaneous miscarriage in our population and to treat them, this study was performed. Materials and MethodsA total of 103 patients with spontaneous abortion meeting inclusion criteria were taken in the study. TORCH profile was sent for those patients and observed the sero-prevalance for IgM and IgG. Thereafter organism was identified and the results were interpreted. Results Out of total 103 patients enrolled 58.25 % of patients were sero-positive for TORCH complex. IgM or IgG Sero-positive for Toxoplasma, Rubella, Cytomegalo virus and Herpes Simplex virus were 11.65% /17.47% ;7.76% / 43.68%; 19.41% / 41.74% and 31.06% / 54.36% respectively. ConclusionIn the present study on analyzing the association of TORCH antibodies in women with spontaneous abortion, infection with Herpes simplex virus was most commonly associated.

Prevalence and Determinants of Toxoplasma Seropositivity among Women Who had Spontaneous Abortion in Gombe, North-Eastern Nigeria

“…The IgM seroprevalence in the current study is comparable to 1/352 (0.3%) found by Onadeko et al [22]. It is, however, lower than 7.6%, 8.9%, 11.7% by Deji-Agboola et al Nasir et al and Lamichhane et al respectively [14,20,35]. This difference may be attributable to the different population studied.…”

“…The seroprevalence was higher than 12.3% and 17.5% by Xiao et al and Lamichhane et al respectively, who used direct agglutination test [35,36]. The difference in the population studied, and diagnostic technique, may account for the difference in seroprevalence.…”

Prevalence of Infectious Agents Causing Abortion in Pregnant Women Using Serological Tests and Histopathological Analysis

“…Because the developing fetus' immune system is unable to fight off the infectious organism, maternal infections, particularly those that occur early in pregnancy, can cause fetal loss or abnormalities. Numerous investigations have revealed a strong connection between maternal TORCH infections and pregnancy loss [13]. Pregnant women experience a decline in immunity due to changes in their endocrine systems, particularly a weakening of T lymphocyte immunological function, which makes them more vulnerable to contracting TORCH or having the virus reactivate in the future.…”

“…A study performed at Nobel Medical College Teaching Hospital by Lamichhane et al [13] revealed that 41.74% were negative and 58.25% were positive for TORCH infections. In contrast to this study, the herpes virus was found to be among the most common causes of first-trimester spontaneous miscarriage in the eastern region of Nepal.…”