Relationship of Vitamin a and Estrogens

Brody, Henry; Goldman, Stanley

doi:10.1210/endo-29-1-164

Cited by 8 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Initial reports suggested that high doses of vitamin A or carotene disrupted the oestrous cycle in rats (Sherwood, Brend & Roper, 1936;Sherwood, Depp, Birge & Dotson, 1937;Burrill & Greene, 1941 ;Brody & Goldman, 1941), but the data were inadequate to warrant such a conclusion and other work showed that chronic feeding of excessive levels of ß-carotene to rats for several generations had no effect on fertility (Bagdon, Zbinden & Studer, 1960). Initial reports suggested that high doses of vitamin A or carotene disrupted the oestrous cycle in rats (Sherwood, Brend & Roper, 1936;Sherwood, Depp, Birge & Dotson, 1937;Burrill & Greene, 1941 ;Brody & Goldman, 1941), but the data were inadequate to warrant such a conclusion and other work showed that chronic feeding of excessive levels of ß-carotene to rats for several generations had no effect on fertility (Bagdon, Zbinden & Studer, 1960).…”

Section: Introductionmentioning

confidence: 99%

Inhibition of cyclic ovarian activity in rats treated chronically with vitamin A

Rj¹

1977

Reproduction

View full text Add to dashboard Cite

The effects of altering the dietary level of vitamin A on cyclic ovarian activity, and serum and hepatic vitamin A concentrations were studied in female rats. High but non-toxic oral doses of retinyl palmitate (5000 i.u., 3 times/week) significantly advanced the age at vaginal opening but had no effect on vaginal and ovarian cycles after 15 weeks of treatment. Hepatic stores of vitamin A were significantly elevated but serum levels were unchanged. Retinol-deficient rats given a supplement of retinoic acid had a normal vaginal opening age but displayed cornified vaginal cells for many of the days that smears were taken. Hepatic and serum vitamin A concentrations were markedly reduced. When treatment with high doses of retinyl palmitate was continued for 9 months, animals developed polycystic anovulatory ovaries which were significantly lighter than those of controls. Retinol-deficient rats given retinoic acid and demonstrating depleted hepatic vitamin A reserves had ovaries of normal weight and containing corpora lutea, indicating that retinol is not necessary for ovulatory activity. Short-term treatment (16 days) of rats with toxic doses of retinyl palmitate (50,000 i.u. daily) sufficient to raise serum and hepatic retinol levels significantly did not alter ovarian cyclicity; corpora lutea were present and ovarian weight was normal.These data indicate that long-term treatment with high but non-toxic doses of vitamin A inhibits cyclic ovulatory activity, perhaps via alteration of a steroidogenic mechanism in the ovary or adrenal since other studies indirectly support the existence of such a relationship. Furthermore, retinoic acid is a sufficient form of vitamin A replacement to maintain cyclic ovarian activity.

show abstract

Section: Introductionmentioning

confidence: 99%

Inhibition of cyclic ovarian activity in rats treated chronically with vitamin A

Rj¹

1977

Reproduction

View full text Add to dashboard Cite

show abstract

Effect of locally applied vitamin a and estrogen on the rat vagina

Khan

1954

Am. J. Anat.

View full text Add to dashboard Cite

The rodent vaginal epithelium is of special interest as a target organ for studying the interaction of endocrine and dietary factors. One of the earliest and most reliable manifestations of a deficiency of vitamin A is the continued cornification of the vaginal epithelium in the rat. Similarly, the rodent vaginal epithelium undergoes marked keratinization and stratification under the influence of estrogenic stimulation.Little is known regarding the basic factors underlying normal and abnormal vaginal cornification. Sherwood et al. ('36, '37) reported that oral administration of large doses of carotene suppressed the estrous vaginal smear picture in the normal rat. However, excessive doses of vitamin A administered orally (Burrill and Greene, '41) or subcutaneously (Brody and Goldman, '41) failed to affect either the normal estrous cycle or the response of the vaginal epithelium to estrogen administration. De Venanzi and Montenegro ( '45) reported that either cod liver oil o r P-carotene administered subcutaneously to the rat modified the vaginal smear so that epithelial cells predominated. Similarly, Thorborg ( '48) noted ' F r o m a thesis submitted to

show abstract

The relationship between vitamin A deficiency and estrogen in producing uterine metaplasia in the rat

1956

Anat. Rec.

View full text Add to dashboard Cite

SIX FIGURESMetaplasia of the lining and glandular epithelium of the uterus has been reported in intact vitamin A deficient rats (Wolbach and Howe, ' 2 5 ) . McCullough and Dalldorf ( '37) maintained that vitamin A deficiency was the primary requisite for uterine metaplasia and that estrone acted solely as a secondary factor. Bo ('55) did not observe metaplasia of uterine epithelium in ovariectomized vitamin A deficient rats and the results obtained indicated that before the manifestations of vitamin A deficiency can be expressed in the uterus, the ovaries by their endocrine function, must stimulate normal growth and function of that organ. It was, therefore, thought advisable to determine whether or not estrogen supplied to ovariectomized vitamin A deficient rats can effectively substitute for the ovary in the production of metaplasia of the uterine epithelium. This is a report of results of administration of estrogen to ovariectomized vitamin A deficient rats. MATERIALS AND METHODSNinety female rats of the Wistar strain were used in these experiments. The animals were 20 to 22 days of age and weighed approximately 35 to 40 gm when placed on the vita-

show abstract

Relationship of Vitamin a and Estrogens

Cited by 8 publications

References 0 publications

Inhibition of cyclic ovarian activity in rats treated chronically with vitamin A

Inhibition of cyclic ovarian activity in rats treated chronically with vitamin A

Effect of locally applied vitamin a and estrogen on the rat vagina

The relationship between vitamin A deficiency and estrogen in producing uterine metaplasia in the rat

Contact Info

Product

Resources

About