Relationship of vitamin D deficiency to cardiovascular disease and glycemic control in patients with type 2 diabetes mellitus: The Silesia Diabetes-Heart Project

Abstract

There is no consistency in the literature between observational and interventional studies regarding vitamin D deficiency (VDD) and both cardiovascular disease (CVD) and glycemic control of diabetes. The outcomes of this observational study among Polish patients with type 2 diabetes revealed that 36% of participants have VDD. We did not find an association between VDD and CVD and the difference between groups in glycemic control of diabetes was insignificant.However we found that patients with VDD had higher prevalence of treatment with sodiumglucose co-transporter-2 inhibitors (SGLT-2i) compared to patients with vitamin D (VD) concentrations within the reference range, which is, to the best of our knowledge, a novel finding. This is of high importance given the concerns that SGLT-2i may possibly affect the bone turnover through a negative influence on VD concentration.