Relationship of white matter network topology and cognitive outcome in adolescents with d-transposition of the great arteries

Panigrahy, Ashok; Schmithorst, Vincent J.; Wisnowski, Jessica L.; Watson, Christopher G.; Bellinger, David C.; Newburger, Jane W.; Rivkin, Michael J.

doi:10.1016/j.nicl.2015.01.013

Cited by 83 publications

(122 citation statements)

References 89 publications

(112 reference statements)

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“…2014) and is mediated by global differences in white matter structural network topology (Panigrahy et al. 2015). These findings suggest that alteration of large‐scale network organization can adversely affect cognitive dysfunction in children with surgically treated CHD.…”

Section: Discussionmentioning

confidence: 99%

“…The topology differences involving network segregation (transitivity) differed, however, from those (modularity and small‐worldness) found to mediate poorer neurocognitive outcomes (Panigrahy et al. 2015). This suggests that different structural features may underlie cognitive as compared to behavioral deficits such as inattentiveness and hyperactivity in d‐TGA subjects.…”

Section: Discussionmentioning

confidence: 99%

“…2015). With regard to network segregation, however, transitivity was found to mediate worse ADHD outcome, in contrast to small‐worldness and modularity mediating worse neurocognitive outcome.…”

Section: Discussionmentioning

confidence: 99%

“…A flow diagram for the construction of WM structural networks from DTI including registration, segmentation, generation of WM fiber tracts using deterministic tractography, and generation of adjacency matrix and nodes (see Panigrahy et al. 2015 for more details).…”

Section: Methodsmentioning

confidence: 99%

“…A previous publication (Panigrahy et al. 2015) focused on relations between d‐TGA, structural network topology, and neurocognitive outcomes (e.g., WISC‐IQ, WIAT scores, memory tests, etc.) Here we focus on inattentiveness and hyperactivity.…”

Section: Methodsmentioning

confidence: 99%

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Organizational topology of brain and its relationship to ADHD in adolescents with d‐transposition of the great arteries

et al. 2016

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ObjectiveLittle is currently known about the impact of congenital heart disease (CHD) on the organization of large‐scale brain networks in relation to neurobehavioral outcome. We investigated whether CHD might impact ADHD symptoms via changes in brain structural network topology in a cohort of adolescents with d‐transposition of the great arteries (d‐TGA) repaired with the arterial switch operation in early infancy and referent subjects. We also explored whether these effects might be modified by apolipoprotein E (APOE) genotype, as the APOE ε2 allele has been associated with worse neurodevelopmental outcomes after repair of d‐TGA in infancy.MethodsWe applied graph analysis techniques to diffusion tensor imaging (DTI) data obtained from 47 d‐TGA adolescents and 29 healthy referents to construct measures of structural topology at the global and regional levels. We developed statistical mediation models revealing the respective contributions of d‐TGA, APOE genotype, and structural network topology on ADHD outcome as measured by the Connors ADHD/DSM‐IV Scales (CADS).ResultsChanges in overall network connectivity, integration, and segregation mediated worse ADHD outcomes in d‐TGA patients compared to healthy referents; these changes were predominantly in the left and right intrahemispheric regional subnetworks. Exploratory analysis revealed that network topology also mediated detrimental effects of the APOE ε4 allele but improved neurobehavioral outcomes for the APOE ε2 allele.ConclusionOur results suggest that disruption of organization of large‐scale networks may contribute to neurobehavioral dysfunction in adolescents with CHD and that this effect may interact with APOE genotype.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Organizational topology of brain and its relationship to ADHD in adolescents with d‐transposition of the great arteries

et al. 2016

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Interplay of brain structure and function in neonatal congenital heart disease

Birca

Vakorin

Porayette

et al. 2016

Ann Clin Transl Neurol

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ObjectiveTo evaluate whether structural and microstructural brain abnormalities in neonates with congenital heart disease (CHD) correlate with neuronal network dysfunction measured by analysis of EEG connectivity.MethodsWe studied a prospective cohort of 20 neonates with CHD who underwent continuous EEG monitoring before surgery to assess functional brain maturation and network connectivity, structural magnetic resonance imaging (MRI) to determine the presence of brain injury and structural brain development, and diffusion tensor MRI to assess brain microstructural development.ResultsNeonates with MRI brain injury and delayed structural and microstructural brain development demonstrated significantly stronger high‐frequency (beta and gamma frequency band) connectivity. Furthermore, neonates with delayed microstructural brain development demonstrated significantly weaker low‐frequency (delta, theta, alpha frequency band) connectivity. Neonates with brain injury also displayed delayed functional maturation of EEG background activity, characterized by greater background discontinuity.InterpretationThese data provide new evidence that early structural and microstructural developmental brain abnormalities can have immediate functional consequences that manifest as characteristic alterations of neuronal network connectivity. Such early perturbations of developing neuronal networks, if sustained, may be responsible for the persistent neurocognitive impairment prevalent in adolescent survivors of CHD. These foundational insights into the complex interplay between evolving brain structure and function may have relevance for a wide spectrum of neurological disorders manifesting early developmental brain injury.

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Disrupted White Matter Topology Organization in Preschool Children with Tetralogy of Fallot

Liu,

Hu,

Zhu

et al. 2024

Brain and Behavior

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Background: Cognitive impairment is the most common long‐term complication in children with congenital heart disease (CHD) and is closely related to the brain network. However, little is known about the impact of CHD on brain network organization. This study aims to investigate brain structural network properties that may underpin cognitive deficits observed in children with Tetralogy of Fallot (TOF).Methods: In this prospective study, 29 preschool‐aged children diagnosed with TOF and 19 without CHD (non‐CHD) were enrolled. Participants underwent diffusion tensor imaging (DTI) scans alongside cognitive assessment using the Chinese version of the Wechsler Preschool and Primary Scale of Intelligence—fourth edition (WPPSI‐IV). We constructed a brain structural network based on DTI and applied graph analysis methodology to investigate alterations in diverse network topological properties in TOF compared with non‐CHD. Additionally, we explored the correlation between brain network topology and cognitive performance in TOF.Results: Although both TOF and non‐CHD exhibited small‐world characteristics in their brain networks, children with TOF significantly demonstrated increased characteristic path length and decreased clustering coefficient, global efficiency, and local efficiency compared with non‐CHD (p < 0.05). Regionally, reduced nodal betweenness and degree were found in the left cingulate gyrus, and nodal efficiency was decreased in the right precentral gyrus and cingulate gyrus, left inferior frontal gyrus (triangular part), and insula (p < 0.05). Furthermore, a positive correlation was identified between local efficiency and cognitive performance (p < 0.05).Conclusion: This study elucidates a disrupted brain structural network characterized by impaired integration and segregation in preschool TOF, correlating with cognitive performance. These findings indicated that the brain structural network may be a promising imaging biomarker and potential target for neurobehavioral interventions aimed at improving brain development and preventing lasting impairments across the lifetime.

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Relationship of white matter network topology and cognitive outcome in adolescents with d-transposition of the great arteries

Cited by 83 publications

References 89 publications

Organizational topology of brain and its relationship to ADHD in adolescents with d‐transposition of the great arteries

Organizational topology of brain and its relationship to ADHD in adolescents with d‐transposition of the great arteries

Interplay of brain structure and function in neonatal congenital heart disease

Disrupted White Matter Topology Organization in Preschool Children with Tetralogy of Fallot

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