Objective: The present study investigates the relationship between BMI and allcause mortality among middle-aged and older adults with or without pre-existing diseases.Design: A population-based cohort study. Setting: The Taiwan Longitudinal Study on Aging is a nationwide prospective cohort study comprising a representative random sample of middle-aged and older adults. The study period was 1996-2007. Subjects: We followed 4145 middle-aged and older adults, totalling 42 353 personyears. Results: Overweight and mildly obese participants showed a 16 % and 30 % decrease in the risk of death, respectively, compared with those of normal weight after adjusting for potential covariates (e.g. demographic characteristics, health behaviour, co-morbidities and physical function). Underweight adults showed a 1·36-fold increased adjusted hazard ratio of death compared with normal-weight adults. Adults with a BMI of 27·0-28·0 kg/m 2 showed a significantly lower adjusted hazard ratio of all-cause mortality rate compared with adults who had normal BMI values when they had coexisting hypertension or diabetes (adjusted hazard ratio = 0·50; 95 % CI 0·30, 0·81 for hypertension and adjusted hazard ratio = 0·41; 95 % CI 0·18, 0·89 for diabetes). Conclusions: The study demonstrates that underweight people have a higher risk of death, and overweight and mildly obese people have a lower risk of death, compared with people of normal weight among middle-aged and older adults. An optimal BMI may be based on the individual, who exhibits pre-existing diseases or not.
Keywords
BMI Mortality Middle-aged and older adultsProspective cohort studyThe prevalence of overweight and obesity is progressively increasing worldwide (1,2) . Overweight and obesity are major risk factors for numerous co-morbidities (3) . However, the effects of overweight and obesity on the risk of death are controversial (4,5) . Jee et al. showed that underweight, overweight and obese men and women have higher death rates than men and women with normal body weight (4) . Flegal et al. performed a systematic review and meta-analysis, and reported a significantly higher risk for all-cause mortality for obese compared with people of normal weight, especially for class II and class III obesity. However, mortality was significantly lower among overweight people compared with people of normal weight (5) . Overweight refers to an excess amount of body weight that may come from muscle, bone, fat and water. Obesity refers to an excess amount of body fat.BMI is a simple index of weight to height that is commonly used to classify overweight and obesity in adults. It is calculated as a person's weight in kilograms divided by the square of his or her height in metres (kg/m