Relationships among delay of diagnosis, extent of disease, and survival in patients with abdominal carcinoid tumors

Toth-Fejel, Su Ellen; Pommier, Rodney F.

doi:10.1016/j.amjsurg.2004.01.019

Cited by 40 publications

(22 citation statements)

References 8 publications

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“…This finding is supported by several oncology studies in other cancer models [4,6,10,11,13,16,[18][19][20][21]26] and three sarcoma studies [23,24,27]. In 2007, we published our findings of bone and soft tissue sarcoma [24].…”

Section: Discussionsupporting

confidence: 76%

Length of Symptoms Before Referral: Prognostic Variable for High-grade Soft Tissue Sarcoma?

Rougraff¹,

Lawrence²,

Davis³

2012

Clinical Orthopaedics &Amp; Related Research

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Section: Discussionsupporting

confidence: 76%

Length of Symptoms Before Referral: Prognostic Variable for High-grade Soft Tissue Sarcoma?

Rougraff¹,

Lawrence²,

Davis³

2012

Clinical Orthopaedics &Amp; Related Research

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“…Delayed diagnosis for abdominal carcinoid tumors and rectal cancers showed no evidence of compromising disease-free survival or overall survival. 6,14,32 Contrary to general opinion, the recent English literature does not support the contention that duration of symptoms before diagnosis affects the outcome of nonscreenable cancers.…”

mentioning

confidence: 83%

“…1,12,13,15,18,25,28,31 Many studies on survival for patients with nonscreened cancers have not found any adverse effect on cancer outcome. 4,6,14,20,22,23,26,27,32 Bladder tumors that involve the deep muscular layer actually have an inverse relationship between length of hematuria before diagnosis and survival. 20 Patients with the shortest duration of symptoms had the worst outcome, which was attributed to the more biologically aggressive nature of these lesions.…”

mentioning

confidence: 99%

Does Length of Symptoms Before Diagnosis of Sarcoma Affect Patient Survival?

Rougraff

Davis²,

Lawrence³

2007

Clinical Orthopaedics &Amp; Related Research

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It generally is accepted that earlier diagnosis of sarcoma is associated with a better disease-free survival. Because the legal community is convinced this is true, a delay in cancer diagnosis is a frequent source of medical malpractice lawsuits. We asked whether symptom duration before diagnosis affected sarcoma outcome. We compiled prospective data from 624 consecutive patients with sarcoma treated from 1992 to 2003. The data included length of symptoms before diagnosis, tumor size and grade, presence of metastatic disease at diagnosis, anatomic location, disease-free survival, overall survival, and local recurrence. Length of symptoms did not predict presence of metastatic disease at diagnosis, survival, or disease-free survival. We found no correlation between the length of a patient's symptoms and the tumor size or anatomic site of disease (axial, proximal, and distal). Tumors were larger at diagnosis in axial and proximal locations than in more peripheral locations, despite no difference in length of symptoms before diagnosis. Patients with sarcoma with long-standing symptoms did not have a worse prognosis than those with a shorter length of symptoms before diagnosis in terms of disease-free survival, overall survival, and presence of metastatic disease at diagnosis.

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“…Average diagnostic delay is up to 5-7 years from the initial onset of symptoms (3). The most common misdiagnosis for abdominal NET is irritable bowel syndrome (37%), followed by food intolerance (18%) and psychiatric disorders (17%) (17). Five percent are misjudged to be caused by menopause (17).…”

Section: Discussionmentioning

confidence: 99%

Carcinoid syndrome caused by a serotonin-secreting pituitary tumour

Lynggård

Laurberg

2014

European Journal of Endocrinology

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Background: Neuroendocrine tumours are most frequently located in the gastrointestinal organ system or in the lungs, but they may occasionally be found in other organs. Case: We describe a 56-year-old woman suffering from a carcinoid syndrome caused by a large serotonin-secreting pituitary tumour. She had suffered for years from episodes of palpitations, dyspnoea and flushing. Cardiac disease had been suspected, which delayed the diagnosis, until blood tests revealed elevated serotonin and chromogranin A in plasma. The somatostatin receptor (SSR) scintigraphy showed a single-positive focus in the region of the pituitary gland and MRI showed a corresponding intra-and suprasellar heterogeneous mass. After pre-treatment with octreotide leading to symptomatic improvement, the patient underwent trans-cranial surgery with removal of the tumour. This led to a clinical improvement and to a normalisation of SSR scintigraphy, as well as serotonin and chromogranin A levels. Conclusion: To our knowledge, this is the first reported case of a serotonin-secreting tumour with a primary location in the pituitary.

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Relationships among delay of diagnosis, extent of disease, and survival in patients with abdominal carcinoid tumors

Cited by 40 publications

References 8 publications

Length of Symptoms Before Referral: Prognostic Variable for High-grade Soft Tissue Sarcoma?

Length of Symptoms Before Referral: Prognostic Variable for High-grade Soft Tissue Sarcoma?

Does Length of Symptoms Before Diagnosis of Sarcoma Affect Patient Survival?

Carcinoid syndrome caused by a serotonin-secreting pituitary tumour

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