Relationships among lymphocyte subsets, cytokines, and the pulmonary inflammation index in coronavirus (COVID‐19) infected patients

Abstract

We explored the relationships between lymphocyte subsets, cytokines, pulmonary inflammation index (PII) and disease evolution in patients with (corona virus disease 2019) COVID-19. A total of 123 patients with COVID-19 were divided into mild and severe groups. Lymphocyte subsets and cytokines were detected on the first day of hospital admission and lung computed tomography results were quantified by PII. Difference analysis and correlation analysis were performed on the two groups. A total of 102 mild and 21 severe patients were included in the analysis. There were significant differences in cluster of differentiation 4 (CD4 + T), cluster of differentiation 8 (CD8 + T), interleukin 6 (IL-6), interleukin 10 (IL-10) and PII between the two groups. There were significant positive correlations between CD4 + T and CD8 + T, IL-6 and IL-10 in the mild group (r 2 = 0Á694, r 2 = 0Á633, respectively; P < 0Á01). After 'five-in-one' treatment, all patients were discharged with the exception of the four who died. Higher survival rates occurred in the mild group and in those with IL-6 within normal values. CD4 + T, CD8 + T, IL-6, IL-10 and PII can be used as indicators of disease evolution, and the PII can be used as an independent indicator for disease progression of COVID-19.

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Pathogenicity, tissue tropism and potential vertical transmission of SARSr-CoV-2 in Malayan pangolins

“…Many of the transcriptomic profiling studies of COVID-19 have been conducted using peripheral blood, often revealing the upregulation of chemokines and cytokines having a direct association with the severe patient condition with SARS-CoV-2 and SARS-CoV (36,37). Expression of CXCL8 (IL-8) is an attractant for neutrophils and associated with SARS-CoV-2 infection (26).…”

Association of immunological features with COVID-19 severity: a systematic review and meta-analysis

“…The variations of immune cells levels are inconsistent in different reports. Most of our included studies found signi cant lower levels of immune cells (CD8 + T, CD4 + T, CD3 + T, B and NK cells) in severe cases compared with mild cases [2,8,12]. Only two studies reported no signi cant decrease in CD8 + T cell level [3,16], while one study reported higher levels of B cell [11] in severe cases.…”