Relationships among Maternal Diet, Serotonin Metabolism at Weaning, and Protein Selection of Progeny

Leprohon, Carol E.; Anderson, G. Harvey

doi:10.1093/jn/112.1.29

Cited by 11 publications

(4 citation statements)

References 24 publications

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“…Furthermore, many BAPs have been identified in casein and soy protein, and these BAPs are known to affect release of peptide hormones in the GI tract (11,29,30,42) and to be absorbed and present in blood (38). The digestion kinetics of proteins also influence their metabolic activities (3) and brain amino acid concentrations and neural activity (24). Furthermore, increased homocysteine concentrations have been observed at weaning in offspring of S diet-fed dams (unpublished observations).…”

Section: Discussionmentioning

confidence: 99%

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Effect of protein source in diets fed during gestation and lactation on food intake regulation in male offspring of Wistar rats

Jahan-Mihan

Smith

Anderson

2011

American Journal of Physiology-Regulatory, Integrative and Comp

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We hypothesized that protein source in the nutritionally adequate AIN-93G diets fed during gestation, lactation, and weaning influences food intake (FI) regulation in male offspring of Wistar rats. Pregnant rats were fed the recommended casein-based (C) or soy protein-based (S) diet during gestation (experiment 1) or during gestation and lactation (experiment 2). Pups (n = 12 per group) weaned to C or S diets were followed for 9 wk (experiment 1) or 14 wk (experiment 2). At termination, body weight was 5.4% and 9.4% higher, respectively, in offspring of dams fed the S diet. Altered FI regulation was shown by failure of devazepide (a CCK-A receptor blocker) to block FI reduction after protein preloads in offspring of S diet-fed dams, whereas it had a strong effect on offspring of C diet-fed dams (P < 0.005). Similarly, naloxone (an opioid receptor blocker) blocked FI reduction more after casein than after soy protein preloads (P < 0.01). In experiment 2, offspring of dams fed the S diet had higher hypothalamic gene expression of agouti related protein at weaning (P < 0.05), and higher FI was found throughout postweaning (P < 0.0001). FI reduction after protein preloads at week 7 and after glucose preloads at week 13 was greater in offspring of C diet-fed dams (P < 0.05). Plasma insulin at weaning and insulin, ghrelin, and glucagon-like peptide-1 at week 15 were higher in offspring of S diet-fed dams (all P < 0.05). In conclusion, nutritionally complete C and S diets consumed during gestation and lactation differ in their effects on body weight and FI regulation in the offspring. Extending the diet from gestation alone to throughout gestation and lactation exaggerated the adverse effects of the S diet. However, the diet consumed postweaning had little effect on the outcome.

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Section: Discussionmentioning

confidence: 99%

“…Possibly the latter is explained by exposure of the pups to the diet, as rats start to eat a solid diet by postnatal day 15 (22). Previous studies have shown that the protein composition of diets fed to rats at postnatal day 17 affects food selection behavior (24).…”

Section: Discussionmentioning

confidence: 99%

Effect of protein source in diets fed during gestation and lactation on food intake regulation in male offspring of Wistar rats

Jahan-Mihan

Smith

Anderson

2011

American Journal of Physiology-Regulatory, Integrative and Comp

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“…The rate of digestion of the proteins and the resulting hormonal responses in the dams and peak amino acid concentrations in the fetus may also influence the development of regulatory systems. The digestion and absorption kinetics of dietary proteins influence catabolic and anabolic activities at the whole-body level [ 158 ] and in the liver [ 159 ] and brain amino acid concentrations and neural activity [ 160 , 161 ]. Based on their rate of digestion and absorption, proteins can be classified as either “fast” or “slow” proteins [ 159 , 161 ].…”

Section: Proposed Mechanisms Of Fetal Programming By Proteinsmentioning

confidence: 99%

The Role of Maternal Dietary Proteins in Development of Metabolic Syndrome in Offspring

et al. 2015

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The prevalence of metabolic syndrome and obesity has been increasing. Pre-natal environment has been suggested as a factor influencing the risk of metabolic syndrome in adulthood. Both observational and experimental studies showed that maternal diet is a major modifier of the development of regulatory systems in the offspring in utero and post-natally. Both protein content and source in maternal diet influence pre- and early post-natal development. High and low protein dams’ diets have detrimental effect on body weight, blood pressure191 and metabolic and intake regulatory systems in the offspring. Moreover, the role of the source of protein in a nutritionally adequate maternal diet in programming of food intake regulatory system, body weight, glucose metabolism and blood pressure in offspring is studied. However, underlying mechanisms are still elusive. The purpose of this review is to examine the current literature related to the role of proteins in maternal diets in development of characteristics of the metabolic syndrome in offspring.

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“…Proteins exhibit their functions in a source-dependent manner. Characteristics of proteins including amino acid composition, (11)(12)(13)(14)(15)(16)(17) amino acid sequence, and bioactive peptides (BAPs) (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) encrypted in protein structures and their digestion kinetics (31)(32)(33)(34)(35) are determinant factors in their effects.…”

Section: Introductionmentioning

confidence: 99%

The effect of source of protein fed during pregnancy and lactation on the development of characteristics of metabolic syndrome in male offspring of obese Wistar rats

Jahan-mihan

2023

J Nutr Sci

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Gestational obesity has major negative impacts on both mothers and their offspring. More than two-thirds of women of reproductive age in the United States are overweight and/or obese. We previously reported that the source of protein in the maternal diet influences the phenotype of offspring born to normal-weight dams. However, whether it has the same effect in obese mothers was unclear. The casein- and soya protein-based diets were fed to obese pregnant Wistar rats and compared for their effects on characteristics of the metabolic syndrome in male offspring. Dams randomized to either a casein (CD) or soya protein (SD) diet (n 12). Pups were weaned to either a CD or SD for 16 weeks. Offspring of SD dams had higher birthweight (P < 0⋅01). Glucose metabolism was not altered at birth but fasting blood glucose (FBG) (P < 0⋅02), insulin (P < 0⋅0002), insulin/glucose ratio (P < 0⋅03), and HOMA-IR index (P < 0⋅0002) were higher in offspring of SD dams at week 17. The pulse rate was higher in dams (P < 0⋅03). Food intake and body weight of offspring were affected by interactive effects of time and dams’ diet (P < 0⋅05). Food intake was not influenced by maternal diet, but it was higher in pups weaned to SD dams (P < 0⋅03) The results of this study indicate that although the source of protein in the maternal diet is still an influencing factor in the outcome of the pregnancy in obese mothers, gestational obesity may mask this effect possibly by imposing general detrimental effects on measured parameters regardless of the source of protein in maternal diet.

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Relationships among Maternal Diet, Serotonin Metabolism at Weaning, and Protein Selection of Progeny

Cited by 11 publications

References 24 publications

Effect of protein source in diets fed during gestation and lactation on food intake regulation in male offspring of Wistar rats

Effect of protein source in diets fed during gestation and lactation on food intake regulation in male offspring of Wistar rats

The Role of Maternal Dietary Proteins in Development of Metabolic Syndrome in Offspring

The effect of source of protein fed during pregnancy and lactation on the development of characteristics of metabolic syndrome in male offspring of obese Wistar rats

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