Relationships among Multifocal Electroretinogram Amplitude, Visual Field Sensitivity, and SD-OCT Receptor Layer Thicknesses in Patients with Retinitis Pigmentosa

Wen, Yuquan; Klein, Martin; Hood, Donald C.; Birch, David G.

doi:10.1167/iovs.11-8410

Cited by 58 publications

(55 citation statements)

References 29 publications

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“…7,8 In 2013, Birch et al 9 evaluated the progression rate of RP by serial measurements of the ellipsoid zone (EZ) band width using SD-OCT. They also showed that the mean rate of decline in the EZ band width (7%) translates into a mean rate of change of 13% for the equivalent area of functioning retina.…”

mentioning

confidence: 99%

Quantification of Ellipsoid Zone Changes in Retinitis Pigmentosa Using en Face Spectral Domain–Optical Coherence Tomography

Hariri

Zhang

et al. 2016

JAMA Ophthalmol

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mentioning

confidence: 99%

Quantification of Ellipsoid Zone Changes in Retinitis Pigmentosa Using en Face Spectral Domain–Optical Coherence Tomography

Hariri

Zhang

et al. 2016

JAMA Ophthalmol

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“…In spite of progressive ONL thinning, most studies showed that the inner retinal layers remained histologically intact, including the inner nuclear layer (INL) and the ganglion cell layer [23,36]. In a clinical study, a decreased outer segment thickness without a significant decrease in the total retinal thickness suggested the presence of inner retinal thickening [37], and morphological studies reported less cellular loss in the INL than in the photoreceptor layers, which was consistent with the presentation of OCT images [38,39]. …”

Section: Inner Retinamentioning

confidence: 99%

Optical Coherence Tomographic Analysis of Retina in Retinitis Pigmentosa Patients

Liu

Liu²,

Li³

et al. 2016

Ophthalmic Res

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Retinitis pigmentosa (RP) is a progressive inherited retinal disease characterized by nyctalopia, visual field constriction, and reduced full-field electroretinograms. The progressive loss of photoreceptors leads to vision loss at the end stage of RP. The prevalence of RP is approximately 1/4,000. Since it is one of the major causes of visual impairment worldwide, morphological and functional assessments are useful for estimating the retinal structure and function in RP. Optical coherence tomography (OCT) is a well-established method of examining retinal structure in situ, and the obtained images by OCT help to analyze morphological abnormalities. Changes revealed by OCT have provided insights into the pathology of RP as well as for predicting the prognosis of RP. In this review, we present the typical morphological changes in RP and their relationships with visual function in eyes with RP.

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“…6,7 This thinning of photoreceptor-attributable reflectivity layers in SD-OCT scans also corresponds to a reduction in multi-focal ERG amplitudes. 8 In short, the SW-AF rings are considered to reflect a transition between abnormal and normal retinal function, with function being relatively normal in retinal areas internal to the ring, reduced within the ring, and absent outside the ring. 9–13 These rings are not genotype specific and are observed in dominant, recessive, X-linked, and syndromic RP.…”

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Quantifying Fundus Autofluorescence in Patients With Retinitis Pigmentosa

Schuerch

Woods

Lee

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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PurposeUsing quantitative fundus autofluorescence (qAF), we analyzed short-wavelength autofluorescent (SW-AF) rings in RP.MethodsShort-wavelength autofluorescent images (486 nm excitation) of 40 patients with RP (69 eyes) were acquired with a confocal scanning laser ophthalmoscope equipped with an internal fluorescent reference. Mean qAF was measured in eight preset segments (qAF8) and in region of interest (ROI)-qAF (200–700 μm) within and external to the borders of the rings at superior, temporal, and inferior sites relative to the ring. For both groups, qAF in patients with RP was compared to age-similar and race/ethnicity-matched healthy eyes at equivalent retinal locations.ResultsIn 71% of eyes of RP patients, qAF8 acquired internal to the inner border of the ring, was within the 95% confidence interval (CI) for healthy eyes, while in the remaining RP eyes qAF8 was either higher or lower than the CI. Measured external to the ring, qAF8 values were within the CI in 47% of RP eyes with the other eyes being higher or lower. In 28% of sites measured by ROI-qAF within the SW-AF ring, values were above the 95% CI of healthy controls. Region of interest-qAF measured just external to the ring was within the CI of healthy eyes in 74% of locations. The average local elevation in qAF within the ring was approximately 15%. In SD-OCT scans, photoreceptor-attributable reflectivity bands were thinned within and external to the ring.ConclusionsIncreased fluorophore production may be a factor in the formation of the SW-AF rings in RP.

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Relationships among Multifocal Electroretinogram Amplitude, Visual Field Sensitivity, and SD-OCT Receptor Layer Thicknesses in Patients with Retinitis Pigmentosa

Cited by 58 publications

References 29 publications

Quantification of Ellipsoid Zone Changes in Retinitis Pigmentosa Using en Face Spectral Domain–Optical Coherence Tomography

Quantification of Ellipsoid Zone Changes in Retinitis Pigmentosa Using en Face Spectral Domain–Optical Coherence Tomography

Optical Coherence Tomographic Analysis of Retina in Retinitis Pigmentosa Patients

Quantifying Fundus Autofluorescence in Patients With Retinitis Pigmentosa

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