Relationships among N,N-dimethylformamide exposure, CYP2E1 and TM6SF2 genes, and non-alcoholic fatty liver disease

Zhou, Ziqi; Sang, Lingli; Wang, Jin; Song, Lin; Zhu, Lejia; Wang, Yangmei; Xiao, Jing; Lian, Yulong

doi:10.1016/j.ecoenv.2021.112986

Cited by 5 publications

(3 citation statements)

References 53 publications

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“…In this section, we present the results of simulating the binding of the inhibitor to the active TiCl 3 /Mg 8 Cl 16 center, as illustrated in Figure 7 a. The choice of this model is based on previous calculations that suggest that the coordination of TiCl 4 with the (104) plane is quite weak or even unstable, whereas the coordination of TiCl 4 with the (110) plane is energetically favored [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ].…”

Section: Resultsmentioning

confidence: 99%

“…All polymer samples were characterized using the MFI test method at a temperature of 230 °C and a load of 2.16 kg. The molecular weight distribution of PP was determined using the Branmer model, which has been used in other research and has shown excellent approximations [ 7 , 18 , 24 ].…”

Section: Methodsmentioning

confidence: 99%

“…One of the most notable conclusions is that an excessive addition of these substances contributes to the poisoning of the catalyst’s active sites [ 17 , 18 , 19 , 20 ]. Additionally, the chemical reactions involved in the formation of these active sites have been studied using DFT [ 20 , 21 , 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

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Dimethylformamide Impurities as Propylene Polymerization Inhibitor

Hernández-Fernández,

González-Cuello,

Ortega-Toro

2023

Polymers

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This research study examined how the use of dimethylformamide (DMF) as an inhibitor affects the propylene polymerization process when using a Ziegler–Natta catalyst. Several experiments were carried out using TiCl4/MgCl2 as a catalyst, aluminum trialkyl as a cocatalyst, and different amounts of DMF. Then, we analyzed how DMF influences other aspects of the process, such as catalyst activity, molecular weight, and the number of branches in the polymer chains obtained, using experimental and computational methods. The results revealed that as the DMF/Ti ratio increases, the catalyst activity decreases. From a concentration of 5.11 ppm of DMF, a decrease in catalyst activity was observed, ranging from 45 TM/Kg to 44 TM/Kg. When the DMF concentration was increased to 40.23 ppm, the catalyst activity decreased to 43 TM/Kg, and with 75.32 ppm, it dropped even further to 39 TM/Kg. The highest concentration of DMF evaluated, 89.92 ppm, resulted in a catalyst productivity of 36.5 TM/Kg and lost productivity of 22%. In addition, significant changes in the polymer’s melt flow index (MFI) were noted as the DMF concentration increased. When 89.92 ppm of DMF was added, the MFI loss was 75%, indicating a higher flowability of the polymer. In this study, it was found that dimethylformamide (DMF) exhibits a strong affinity for the titanium center of a Ziegler–Natta (ZN) catalyst, with an adsorption energy (Ead) of approximately −46.157 kcal/mol, indicating a robust interaction. This affinity is significantly higher compared to propylene, which has an Ead of approximately −5.2 kcal/mol. The study also revealed that the energy gap between the highest occupied molecular orbital (HOMO) of DMF and the lowest unoccupied molecular orbital (SOMO) of the Ziegler–Natta (ZN) catalyst is energetically favorable, with a value of approximately 0.311 eV.

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