Relationships between age-related biochemical markers of bone turnover and OPG, TGF-β1 and TGF-β2 in native Chinese women

Chen, Chao; Liang, Meng-Ke; Zhang, Hong; Peng, Yi-Qun; Wu, Xuesong; Wu, Xi-Yu; Liao, Er-Yuan

doi:10.3109/07435800.2013.840654

Cited by 7 publications

(5 citation statements)

References 32 publications

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“…This review is focused on the diagnostic value of several new serum markers of bone metabolism, including bonespecific alkaline phosphatase (bAP. Some researchers find similar results to ours, their studies have highlighted the correlation between the BAP and the sexual hormones during menopause; they showed that the concentration of BAP is related to the concentration of the follicle stimulating hormone (FSH) among menopausal women (13)(14)(15) . A Chinese investigation reported that the concentration of FSH explained 1.9-11.8% of BAP concentration among postmenopausal women (13).…”

Section: Discussionsupporting

confidence: 82%

“…Some researchers find similar results to ours, their studies have highlighted the correlation between the BAP and the sexual hormones during menopause; they showed that the concentration of BAP is related to the concentration of the follicle stimulating hormone (FSH) among menopausal women (13)(14)(15) . A Chinese investigation reported that the concentration of FSH explained 1.9-11.8% of BAP concentration among postmenopausal women (13). A Moroccan study, among menopausal women found an correlation between ovarian hormones Estradiol and the Osteocalcin but the authors didn't consider the BAP in their study (5).…”

Section: Discussionsupporting

confidence: 82%

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Association between the bone turnover markers and the gynecologic factors among Moroccan women

Nejjar

Bour

Sfendla³

et al. 2017

AABS

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Background:The action of bone cells on the bone mineral density can be highlighted from their enzymatic activities, by the bone alkaline phosphates (BAP) and the Cross Laps-telopeptide terminal of the collagen type 1 (β-CTX). They are reliable to explore the activity of bone turnover. We aim to put in perspective the association between gynecological factors and the concentration of bone turnover markers (BTMs) among Moroccan women.Methods: This is a cross-sectional study of 125 women from February to April 2015. A randomized sample was made. The biochemical parameters of bone metabolism concerned serum calcium, 25 hydroxyvitamin D (25OHD), parathyroid hormone (PTH), phosphorus , BAP and β-CTX. All data related to gynecologic, sociodemographic and anamnesis parameters was collected by standardized questionnaire.Result: Among 125 women, 64(51.42) were menopausal, the mean BAP was 22.1±7.6 ng/L, the median of the interval between successive births "IBSB" and of β-CTX were 36.0 [24.0-58.0] months, 368.5 [237.0-504.8]ng/L. A positive correlation was observed between the β-CTX and IBSB (r=0.2,p=0.05). The BAP concentration was higher in menopausal women (p<0.001). The linear regression showed that 12% of BAP concentration was associated to the menopause (R 2 =0.12, p=0.001) but no associated factors was founded with concentration of β-CTX. Conclusion:Our study shows that the menopause is associated factor with concentration of BAP and IBSB is correlated with the concentration of β-CTX. Keywords IntroductionThe bone remodeling is a complex physiological process during which the osteoclasts, cells of bone resorption, and the osteoblasts, cells of bone formation, act in sequential and coupled frequencies to destruct and renew the bone matrix. The objective of this physiological process is to lead an adequate bone mineral density (BMD) depending on the age and the sex (1). This bone remodeling process is under the action of several factors such as biological mediators, cited the vitamin D and the calcium, also under the action of sexual hormones and under the action of some external parameters related to the lifestyle of the person (1, 2).The action of these cells on the bone can be highlighted from their enzymatic activities by the biochemical markers of bone turnover: Bone Alkaline Phosphatase (BAP) and C-telopeptide Terminal Collagen type 1 (β-CTX). The BAP is an enzyme of the bone formation specific to the osteoblasts whereas the β-CTX is an enzyme of bone resorption specific to the osteoclasts (2). The use of these enzymes are reliable to their non invasive exploration of bone turnover (3), they allow in association with the bone densitometry to estimate the loss of bone and to monitor the response of therapeutic effect of several bone diseases (4).The trend to establish a link between markers and BMD was also subject to research among Moroccan researchers (5,6). Yet, to our knowledge, no study so far in Morocco has been undertaken to study the associated factors with the concentration of biochemical of bo...

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 82%

Association between the bone turnover markers and the gynecologic factors among Moroccan women

Nejjar

Bour

Sfendla³

et al. 2017

AABS

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“…Results can vary with time of day, season, diet and exercise. Reference intervals for bone turnover markers across ethnic groups have been reported for example in UK and Europe, [147][148][149] China [150][151][152] and Japan. 153,154 In Table 7, representative reference intervals for bone markers pre-and postmenopause are summarized.…”

Section: Skeletonmentioning

confidence: 99%

Biochemistry of the menopause

Honour

2017

Ann Clin Biochem

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The life of a human female is characterized from teenage years by monthly menstruation which ceases (the menopause) typically between the age of 40 and 60 years. The potential for reproduction declines and ceases as the ovaries become depleted of follicles. A transition period in mid-life, for 2 to 10 years, when menstruation is less regular is called the perimenopause. The menopause is associated with a significant decline in plasma concentrations of sex hormones, an increase in the concentrations of the gonadotrophins and changes in other hormones such as the inhibins. These changes are superimposed with effects of aging, social and metabolic factors, daily activity and well-being. Although the menopause is entirely natural, in some cases ovarian failure can occur earlier than usual; this is pathological and warrants careful biochemical investigations to distinguish it from conditions causing infertility. Elderly females are affected by a range of clinical disorders including endocrine, cardiovascular, skeletal, urogenital tract and immunological systems, body mass, vasomotor tone, mood and sleep pattern. Reference intervals for many diagnostic biochemical tests for the menopause need to be used when interpreting results in clinical investigations for patient management. The standardization and harmonization of assays are being addressed. Many women now choose to develop their career before bearing children, and the health service has had to change services around this. This review does not cover screening for and tests during pregnancy. The review is timely since the population is aging and there will be more demand on healthcare services.

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“…Here, several classical SASP proteins, including TGF-β2, OPG, MMP9, TIMP1, MIF1, PRDXs, and IGFBP3, were found to be upregulated in aged OLCS exosomes. Among them, TGF-β2 and OPG are important mediators of bone metabolism; serum levels of TGF-β2 and OPG have shown significant positive correlations with bone turnover markers in Chinese women [52]. TIMP1, a tissue inhibitor of metalloproteinases (MMPs), is expressed in both osteocytes and osteoblasts and maintains the balance of bone matrix degradation by regulating MMP levels [53].…”

Section: Discussionmentioning

confidence: 99%

Ageing characteristics of bone indicated by transcriptomic and exosomal proteomic analysis of cortical bone cells

Zhang

et al. 2019

J Orthop Surg Res

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Background Degenerative changes in the skeleton play an important role in ageing. As the foremost sensors and orchestrators of bone remodelling, osteocytes contribute significantly to the health of the skeleton. Embedded in a mineralized bone matrix, the osteocyte network and the surrounding lacunar canaliculae work together as a functional syncytium—the osteocytic lacunar-canalicular system (OLCS). However, changes in the OLCS during ageing and related mechanisms cannot be fully understood by using traditional histological analysis. Methods To link the phenotypes of aged osteocytes and their functional changes during ageing, we analysed the changes in the gene expression profiles of bone cells and the proteomic profiles of OLCS exosomes derived from aged and young cortical bone. Results Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of differentially expressed genes (DEGs) suggested that a decline in cell energy metabolism and an increased level of the proinflammatory state are major characteristics of bone ageing. Moreover, some DEGs were key regulators of bone mechanical sensation and bone remodelling, which are indicative of reduced bone-specific function with age. Further, the identified proteins in OLCS exosomes showed potential changes in the secretory function bone. Compared with young controls, the decreased functional proteins in aged OLCS exosomes were enriched mainly in GO terms that included regulating bone development and remodelling, cell-matrix adhesion, and cell clearance and homeostasis. Notably, several functions of exosomal proteins of the aged group revealed potential new roles, such as regulating innate and adaptive immunity, wound healing, and angiogenesis and eliminating oxidative stress. Conclusion The information obtained from bone cells and OLCS exosomes will help us discover new features of bone ageing. Electronic supplementary material The online version of this article (10.1186/s13018-019-1163-4) contains supplementary material, which is available to authorized users.

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Relationships between age-related biochemical markers of bone turnover and OPG, TGF-β1 and TGF-β2 in native Chinese women

Cited by 7 publications

References 32 publications

Association between the bone turnover markers and the gynecologic factors among Moroccan women

Association between the bone turnover markers and the gynecologic factors among Moroccan women

Biochemistry of the menopause

Ageing characteristics of bone indicated by transcriptomic and exosomal proteomic analysis of cortical bone cells

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