Relationships between anthropometric adiposity indexes and bone mineral density in a cross-sectional Chinese study

Deng, Guijuan; Lu, Yin; Li, Kai; Hu, Bo; Xia, Cheng; Zhang, Yong; Xu, Liangzhi; Xu, Shaoqi; Zhu, Lei; Shao, Jiman; Hao, Xiaoyan; Zhou, Jun; Tang, Jingrong; Li, Wei; Jiang, Yu; Cheng, Xiaoguang

doi:10.1016/j.spinee.2020.10.019

Cited by 16 publications

(10 citation statements)

References 33 publications

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“…The results suggest that maintaining a BMI at a slightly overweight level (approximately 26 kg/m2) may obtain optimal BMD [ 34 ]. A study on the relationship between the obesity index and BMD in Chinese people found that BMI levels were positively correlated with LS-BMD in men aged over 60 years [ 35 ]. In our MR study, we found a positive causal relationship between BMI levels and HE bone mineral density in men.…”

Section: Discussionmentioning

confidence: 99%

Causal relationships between sex hormone traits, lifestyle factors, and osteoporosis in men: A Mendelian randomization study

Wang

Cheng²,

Wei³

et al. 2022

PLoS ONE

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Although observational studies have explored factors that may be associated with osteoporosis, it is not clear whether they are causal. Osteoporosis in men is often underestimated. This study aimed to identify the causal risk factors associated with bone mineral density(BMD) in men. Single nucleotide polymorphisms (SNPs) associated with the exposures at the genome-wide significance (p < 5x10-8) level were obtained from corresponding genome-wide association studies (GWASs) and were utilized as instrumental variables. Summary-level statistical data for BMD were obtained from two large-scale UK Biobank GWASs. A Mendelian randomization (MR) analysis was performed to identify causal risk factors for BMD. Regarding the BMD of the heel bone, the odds of BMD increased per 1-SD increase of free testosterone (FT) (OR = 1.13, P = 9.4 × 10−17), together with estradiol (E2) (OR = 2.51, P = 2.3 × 10−4). The odds of BMD also increased with the lowering of sex-hormone binding globulin (SHBG) (OR = 0.87, P = 7.4 × 10−8) and total testosterone (TT) (OR = 0.96, P = 3.2 × 10−2) levels. Regarding the BMD of the lumbar spine, the odds of BMD increased per 1-SD increase in FT (OR = 1.18, P = 4.0 × 10−3). Regarding the BMD of the forearm bone, the odds of BMD increased with lowering SHBG (OR = 0.75, P = 3.0 × 10−3) and TT (OR = 0.85, P = 3.0 × 10−3) levels. Our MR study corroborated certain causal relationships and provided genetic evidence among sex hormone traits, lifestyle factors and BMD. Furthermore, it is a novel insight that TT was defined as a disadvantage for osteoporosis in male European populations.

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Section: Discussionmentioning

confidence: 99%

Causal relationships between sex hormone traits, lifestyle factors, and osteoporosis in men: A Mendelian randomization study

Wang

Cheng²,

Wei³

et al. 2022

PLoS ONE

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“…WHtR is based on WC and reflects central obesity [ 60 ]. Abdominal obesity may increase BMD by stimulating bone growth and increasing the bones’ weight bearing capacity [ 61 ]. AVI and BRI are used to assess obesity and are associated with impaired glucose tolerance, and they have been reported to be good indicators of MetS status [ 34 , 62 ].…”

Section: Discussionmentioning

confidence: 99%

Associations between Metabolic Syndrome and Obesity-Related Indices and Bone Mineral Density T-Score in Hemodialysis Patients

Wung

Chung

et al. 2021

JPM

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Previous studies have reported inconsistent results regarding the associations between metabolic syndrome (MetS) and obesity-related indices and bone mineral density (BMD). However, no previous studies have reported these associations among hemodialysis (HD) patients. The aims of this study were to investigate associations between MetS and its components and BMD T-score in HD patients and also between obesity-related indices and BMD T-score in HD patients with and without MetS. MetS was defined according to the Adult Treatment Panel III for Asians, and BMD T-score was calculated using dual-energy X-ray absorptiometry. Eight obesity-related indices were evaluated, including lipid accumulation product (LAP), visceral adiposity index (VAI), body adiposity index, conicity index (CI), body roundness index (BRI), abdominal volume index (AVI), waist-to-height ratio (WHtR), waist–hip ratio, and body mass index (BMI). One hundred and sixty-four patients undergoing HD were enrolled, and the prevalence of MetS was 61.6%. MetS was significantly associated with high lumbar spine and total hip T-scores. Regarding the MetS components, abdominal obesity and low HDL-C were significantly associated with high lumbar spine, femoral neck, and total hip T-scores; hypertriglyceridemia was significantly associated with high lumbar spine and total hip T-scores; hyperglycemia was significantly associated with a high lumbar spine T-score, whereas high blood pressure was not associated with T-score at any site. In the patients with MetS, BMI, WHtR, AVI, and BRI were significantly associated with T-score at all sites, and high CI, VAI, and LAP were also related to a high lumbar T-score. However, these indices were not associated with T-score at any site in patients without MetS. This study demonstrated positive associations between MetS and its five components and BMD T-score among HD patients. MetS, abdominal obesity, hypertriglyceridemia, and low HDL-cholesterol were associated with low risk of osteoporosis among the HD patients. Furthermore, we found that some obesity-related indices were associated with BMD T-score among HD patients with MetS but not in those without MetS. Our study highlights the importance of BMI, WHtR, AVI, and BRI in predicting the risk of osteoporosis among HD patients with MetS. In clinical practice, they can be easily calculated through simple anthropometric measurements and routine laboratory examinations and be used to quickly and conveniently assess the risk of osteoporosis among HD patients.

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“…When dealing specifically with central adiposity, the reported results from several observational studies are not consistent. In terms of WC, a cross-sectional study of 4663 Chinese adult men and another cross-sectional study of 3457 Chinese adults found that WC was a negative predictor of BMD [ 19 , 20 ]. This relationship was also found in a Korean study of 8981 individuals [ 21 ] and a small study of 271 overweight adolescents [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…In contrast to the HCadjBMI trait, we observed the protective effect of WHR, not WHRadjBMI, on BMD in this study. A Chinese cross-sectional study and another small study found that WHR was inversely related to bone mass [ 20 , 27 ]. However, the results from another Chinese cohort study supported the protective effect of WHR on BMD [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

The relationship between central obesity and bone mineral density: a Mendelian randomization study

Jing

Zhang

et al. 2022

Diabetol Metab Syndr

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Background The relationship between obesity and osteoporosis is an important public health issue. The goal of this study was to investigate whether and to what extent central obesity traits affect bone mineral density (BMD). Methods We conducted a two-sample Mendelian randomization analysis. Genomewide significant single nucleotide polymorphisms associated with waist circumference, hip circumference, waist-to-hip ratio, waist circumference adjusted by body mass index (WCadjBMI), hip circumference adjusted by BMI (HCadjBMI) and waist-to-hip ratio adjusted by BMI (WHRadjBMI) were obtained from a large-scale database containing 224,459 samples. The BMD summary dataset was obtained from a UK Biobank database including 265,627 participants. Results The results provided strong evidence that the HCadjBMI trait was causally and negatively associated with BMD (β: − 0.135, 95% CI − 0.216 to − 0.054; P = 0.001), while the WHR trait was causally and positively associated with BMD (β: 0.194, 95% CI 0.062 to 0.325, P = 0.004). No significant effects were observed for other traits on BMD. Conclusions This study indicates variations in the abilities of different central obesity traits to influence BMD. These results should be considered in further studies and public health measures on obesity and osteoporosis prevention strategies.

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Relationships between anthropometric adiposity indexes and bone mineral density in a cross-sectional Chinese study

Cited by 16 publications

References 33 publications

Causal relationships between sex hormone traits, lifestyle factors, and osteoporosis in men: A Mendelian randomization study

Causal relationships between sex hormone traits, lifestyle factors, and osteoporosis in men: A Mendelian randomization study

Associations between Metabolic Syndrome and Obesity-Related Indices and Bone Mineral Density T-Score in Hemodialysis Patients

The relationship between central obesity and bone mineral density: a Mendelian randomization study

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