Relationships between atopy and bacterial infections

Mucha, Samantha M.; Baroody, Fuad M.

doi:10.1007/s11882-003-0045-2

Cited by 18 publications

(9 citation statements)

References 42 publications

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“…As in asthma, eosinophils are also characteristically implicated in seasonal and perennial rhinitis [6], chronic rhinosinusitis [7], nasal polyposis [8], idiopathic eosinophilic syndromes and atopic dermatitis [9][10][11][12]. Accumulation of eosinophils also occurs in some other disorders such as parasitic infections and cancer [13,14].…”

Section: Introductionmentioning

confidence: 99%

Pharmacological Regulation of Human Eosinophil Apoptosis

Kankaanranta

Moilanen²,

Zhang

2005

CDTIA

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Eosinophilic inflammation of the airways is a key characteristic of asthma. The balance between eosinophil recruitment into the lung and their removal from the lungs determines the number of eosinophils in the airways. Apoptosis or programmed cell death is of importance in the removal of eosinophils from the lungs. In asthma, eosinophil apoptosis is delayed. Glucocorticoids enhance eosinophil apoptosis, whereas beta(2)-agonists may delay apoptosis in eosinophils. Detailed knowledge on the mechanisms that regulate this process gives an opportunity to develop specific asthma therapies targeting the eosinophil. This review aims to focus on the signalling leading to or preventing apoptosis in human eosinophils as well as reviews the current evidence on the regulation of eosinophil apoptosis and/or survival in allergic diseases.

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Section: Introductionmentioning

confidence: 99%

Pharmacological Regulation of Human Eosinophil Apoptosis

Kankaanranta

Moilanen²,

Zhang

2005

CDTIA

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“…Mast cells are common in the normal middle ear (ME), where they account for the most numerous population of resident leukocytes by far, [17][18][19] a finding that has supported previous attempts to connect allergy to the expression of otitis media. [20][21][22] Although allergic challenge has been shown to induce ME effusion, [23][24][25] a link between atopy and otitis media in human beings has been difficult to establish.…”

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confidence: 99%

Role of mast cells in otitis media

Ebmeyer

Furukawa

Pak³

et al. 2005

Journal of Allergy and Clinical Immunology

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“…Thirdly, different inflammatory response to infections and high incidence of comorbidity with bacterial infections including sinusitis (Mucha and Baroody 2003) in atopic subjects may be a contributing factor in pathogenesis of bronchiectasis. It has been reported that virus-induced inflammatory changes in upper respiratory tract infections are more prolonged in atopic than in nonatopic subjects (Corne et al 2001), suggesting that it might have resulted in higher probability of bronchiectasis.…”

Section: Discussionmentioning

confidence: 99%

Atopy in Patients with Bronchiectasis: More than Coincidence

Öztürk

Tozkoparan

Karaayvaz

et al. 2006

Tohoku J. Exp. Med.

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Bronchiectasis is common in developing countries, but its precise underlying mechanism can be detected in only about 40% of the cases. The studies reporting the frequency of atopy and its relation to radiological findings and lung function in bronchiectasis are limited in number, and the results are controversial. The present study was designed to investigate the relationship between atopy and bronchiectasis by means of high resolution computed tomography (HRCT) and pulmonary function tests. Skin prick test, HRCT and pulmonary function tests, including spirometric values of forced expiratory volume in one second (FEV1), FEV1/FVC (forced vital capacity) ratio were performed in 121 bronchiectatic patients of unknown etiology and in 68 healthy controls. Atopy and HRCT scores for the severity of atopy and extent of bronchiectasis respectively were determined for each patient. The rate of atopy (48.8% vs 11.8%) and mean atopy score (14.3 ± 10.1 mm vs 5.5 ± 2.1 mm) were significantly higher in patients with bronchiectasis than those in controls. Atopic patients had significantly worse spirometric values and more extended bronchiectasis than non-atopics. There is a significant correlation between atopy and HRCT scores (r = 0.54, p < 0.001), indicating that the more severe atopy is the more extended bronchiectasis. In conclusion, we suggest that the rate of atopy is higher in bronchiectatic patients than that in healthy controls. Bronchiectatic patients with atopy have lower spirometric values and higher HRCT scores. Atopy might be considered as a deteriorating and/or a causative or contributing factor for development of bronchiectasis.

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Relationships between atopy and bacterial infections

Cited by 18 publications

References 42 publications

Pharmacological Regulation of Human Eosinophil Apoptosis

Pharmacological Regulation of Human Eosinophil Apoptosis

Role of mast cells in otitis media

Atopy in Patients with Bronchiectasis: More than Coincidence

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