Relationships between autonomic nerve function and gastric emptying in patients with autoimmune gastritis

Kalkan, Çağdaş; Soydal, Çiğdem; Özkan, Elgin; Maden, Ata; Soykan, İrfan

doi:10.1007/s10286-016-0353-y

Cited by 6 publications

(5 citation statements)

References 22 publications

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“…These changes indicate that the thiol/disulfide redox balance shifted to the disulfide bond side in acute pancreatitis [23]. Patients with AIG exhibited altered autonomic function, indicating an important association between autonomic dysfunction and delayed GE [18]. This result and the existence of a positive association between elevated oxidative stress and autonomic dysfunction have led us to examine the relationship between GE and TDH [35,36].…”

Section: Discussionmentioning

confidence: 99%

“…The study was approved by the local ethical committee of the related institution and informed consent was obtained from all subjects before conducting the study. Some of the data included in this research were used in other studies previously [18,19].…”

Section: Gastric Emptying Studymentioning

confidence: 99%

“…Moreover, it has been found that there is a change in autonomic nerve function of some AIG patients. This has revealed a close association between altered autonomic nervous system function and delay in gastric emptying (GE) [18]. Therefore, the aim of our research was to examine dynamic TDH and IMA levels in AIG and specify possible factors associated with this oxidation.…”

Section: Introductionmentioning

confidence: 99%

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Thiol/disulphide homeostasis and ischemia modified albumin levels in autoimmune gastritis and their relations with gastric emptying

Erel

et al. 2020

Turk J Med Sci

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Background/aim: Autoimmune gastritis is an autoimmune and inflammatory disorder. The aim of this study is to examine dynamic thiol/disulfide homeostasis and ischemia modified albumin levels, and to analyze the association between thiol/disulfide homeostasis and gastric emptying time in autoimmune gastritis. Materials and methods:Thiol/disulfide homeostasis tests and ischemia modified albumin levels were determined in 50 autoimmune gastritis patients and 53 healthy subjects. Patients with delayed and normal gastric emptying were compared by thiol/disulfide homeostasis tests. Results:The results showed that native thiol (μmol/L), total thiol (μmol/L), and native thiol/total thiol ratio (%) of the patients with autoimmune gastritis decreased compared to the control group (177.7 ± 34.18 vs. 245.25 ± 33.83, P = 0.001, 227.25 ± 36.78 vs. 284.20 ± 27.19, P = 0.03, and 8.84 ± 1.1 vs. 7.74% ± 1.3%, P = 0.001). In addition, native thiol (μmol/L), total thiol (μmol/L), and native thiol/ total thiol ratio (%) were found to be lower in patients with delayed gastric emptying (198.65 ± 24.27 vs. 167.12 ± 20.51, 241.81 ± 27.14 vs. 213.92 ± 26.35, 8.34 ± 1.29 vs. 7.20 ± 1.83, P = 0.001). Disulfide level, disulfide/native thiol, disulfide/total thiol (P = 0.001) ratios, and ischemia modified albumin levels (ABSU, 0.71 ± 0.08 vs. 0.83 ± 0.07) were found to be higher in autoimmune gastritis patients with delayed gastric emptying (P = 0.001). Conclusion:The results showed that thiol/disulfide homeostasis in patients with autoimmune gastritis caused an increase in ischemia modified albumin and disulfide whereas a decrease in thiols. An altered thiol/disulfide balance was also observed in patients with delayed gastric emptying. These results suggest that the oxidative process is involved in patients with autoimmune gastritis.

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Section: Discussionmentioning

confidence: 99%

Section: Gastric Emptying Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Thiol/disulphide homeostasis and ischemia modified albumin levels in autoimmune gastritis and their relations with gastric emptying

Erel

et al. 2020

Turk J Med Sci

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“…Codes used for "simple" and "global" score calculations and a score of 7 or higher was accepted as severe autonomic dysfunction (12). Some data included in this study were used in previous studies (7). Table 1 were used in order to define whether autonomic dysfunction occurs in autoimmune gastritis patients.…”

Section: Autonomic Nerve Function Testsmentioning

confidence: 99%

“…The presence of autonomic nervous dysfunction affects the clinical progress of these kinds of diseases (5). There is enough evidence that AIG involves autonomic nervous system and the vagus nerve has a significant role in the control of gastric motility (6,7). Furthermore, gastric emptying is also controlled by vagal and sphlanchnic nerves and intrinsic innervation via the enteric nervous system.…”

Section: Introductionmentioning

confidence: 99%