Relationships between cartilage thickness and subchondral bone mineral density in non-osteoarthritic and severely osteoarthritic knees: In vivo concomitant 3D analysis using CT arthrography

Omoumi, Patrick; Babel, Hugo; Jolles, Brigitte M.; Favre, Julien

doi:10.1016/j.joca.2018.12.014

Cited by 23 publications

(23 citation statements)

References 51 publications

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“…Thinner cartilage was associated with denser subchondral bone in OA knees, while thicker cartilage was associated with denser subchondral bone in control knees. The results support the theory that OA disrupts the normal homeostatic relationship between cartilage and subchondral bone 47 . Dube et al used statistical shape modeling of MRI to investigate changes in femur and tibia morphology over 24 months in 600 subjects from the OAI.…”

Section: Bone In Knee Oasupporting

confidence: 84%

Osteoarthritis year in review 2019: imaging

Kijowski

Demehri

Roemer

et al. 2020

Osteoarthritis and Cartilage

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PET-MRI". Articles were reviewed to determine relevance based upon the following criteria: 1) study involved human subjects with OA or risk factors for OA and 2) study involved imaging to evaluate OA disease status or OA treatment response. Relevant articles were ranked according to scientific merit, with the best publications selected for inclusion in the narrative report. Results: The PubMed search revealed a total of 1257 articles, of which 256 (20.4%) were considered relevant to OA imaging. Two-hundred twenty-six (87.1%) articles involved the knee joint, while 195 (76.2%) articles involved the use of magnetic resonance imaging (MRI). The proportion of published studies involving the use of MRI was higher than previous years. An increasing number of articles were also published on imaging of subjects with joint injury and on deep learning application in OA imaging. Conclusion: MRI and other imaging modalities continue to play an important role in research studies designed to better understand the pathogenesis, progression, and treatment of OA.

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Section: Bone In Knee Oasupporting

confidence: 84%

Osteoarthritis year in review 2019: imaging

Kijowski

Demehri

Roemer

et al. 2020

Osteoarthritis and Cartilage

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“…The relationship between subchondral bone degeneration and OA severity has previously been reported in several studies. Among them, Omoumi et al [13] have shown that in knee OA, cartilage thickness and subchondral bone mineral density based on CT arthrography are negatively correlated, which indicate mutual adaptation in cartilage-subchondral bone loses in the OA state. Bobinac et al [33] showed the same trends as reported in the current study in subchondral bone and cartilage degeneration under OA; however, they used a 2D histology method for STB microarchitecture and did not consider the effect of knee alignment changes.…”

Section: Discussionmentioning

confidence: 99%

“…The properties and structure of the STB in OA could be characterized by dual X-ray absorptiometry (DXA) [11], X-ray computed tomography (CT) [12], CT arthrography [13], micro-CT (μCT) [14], and magnetic resonance imaging (MRI) [15,16]. Previous studies have reported that knee OA severity, based on histological score [17], Kellgren-Lawrence (K-L) grade [18], cartilage defects, and cartilage thinning, was positively correlated with tibial plateau subchondral bone mineral density (BMD), trabecular bone volume fraction (BV/TV), trabecular number (Tb.N), and trabecular thickness (Tb.Th), suggesting that subchondral bone is closely related to OA severity.…”

Section: Introductionmentioning

confidence: 99%

Association between knee alignment, osteoarthritis disease severity, and subchondral trabecular bone microarchitecture in patients with knee osteoarthritis: a cross-sectional study

et al. 2020

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Background: Knee osteoarthritis (OA) is a common disabling disease involving the entire joint tissue, and its onset and progression are affected by many factors. However, the current number of studies investigating the relationship between subchondral trabecular bone (STB), knee alignment, and OA severity is limited. We aimed to investigate the variation in tibial plateau STB microarchitecture in end-stage knee OA patients and their association with knee alignment (hip-knee-ankle, HKA, angle) and OA severity. Methods: Seventy-one knee OA patients scheduled for total knee arthroplasty (TKA) underwent preoperative radiography to measure the HKA angle and Kellgren-Lawrence grade. Tibial plateaus collected from TKA were scanned using micro-computed tomography to analyze the STB microarchitecture. Histological sections were used to assess cartilage degeneration (OARSI score). Correlations between the HKA angle, OA severity (OARSI score, Kellgren-Lawrence grade), and STB microarchitecture were evaluated. Differences in STB microstructural parameters between varus and valgus alignment groups based on the HKA angle were examined. Results: The HKA angle was significantly correlated with all STB microarchitecture parameters (p < 0.01). The HKA angle was more correlated with the medial-to-lateral ratios of the microarchitecture parameters than with the medial or lateral tibia plateaus. The HKA angle and all STB microarchitecture parameters are significantly correlated with both the OARSI score and Kellgren-Lawrence grade (p < 0.01). Conclusions: The STB microarchitecture is associated with the HKA angle and OA severity. With the increase of the knee alignment deviation and OA severity, the STB of the affected side tibial plateau increased in bone volume, trabecular number, and trabecular thickness and decreased in trabecular separation.

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“…In recent years, substantial evidence has shown that subchondral bone and cartilage are a closely related integrated unit and mutually adaptable [17][18][19]. In the early stage of KOA, the absorption of subchondral bone is enhanced, and the mechanical strength of the bone is reduced.…”

Section: Discussionmentioning

confidence: 99%

Osteoporosis is Associated with Varus Deformity in Postmenopausal Women with Knee Osteoarthritis: A Case-Control Study

Zhang

Zhuang

Chen

et al. 2021

Preprint

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Background: Varus deformity of the knee is a common pathological characteristic in knee osteoarthritis (KOA), and not enough attention has been given to the relationship between knee varus deformity and the state of systemic bone mass. The purpose of this study is to evaluate the potential relationship between bone mineral density (BMD) and varus deformity in postmenopausal women with KOA.Methods: This case-control study included 202 postmenopausal women with KOA with or without varus deformity. The hip-knee-ankle angle of the lower extremity (HKA), medial distal femoral angle (MDFA), medial proximal tibial angle (MPTA), and the angle of the joint line (JLCA) were measured in all patients. The BMD of the lumbar (L1-L4), left femoral neck, and left hip were measured by dual-energy X-ray absorptiometry in all patients. The difference in BMD between the knee varus deformity group and the normal limb alignment group was compared, and the relationship between the different angles of limb alignment and the BMD values at different sites was evaluated.Results: The BMD at different sites of the knee varus deformity group was lower than of the normal limb alignment group, and the incidence of osteoporosis was higher. Pearson correlation analysis showed that BMD of the lumbar spine (L1-L4), left femoral neck and left hip joint were positively correlated with the HKA, but negatively correlated with JLCA. MPTA was positively correlated with the left femoral neck and left hip joint BMD, but not correlated with lumbar bone density. Furthermore, in the normal limb alignment group, the HKA was only negatively correlated with JLCA, but not significantly correlated with MDFA and MPTA. In the varus deformity group, the HKA was not only negatively correlated with JLCA but also positively correlated with MDFA and MPTA. Conclusions: Osteoporosis should be an important predicting factor for exacerbating knee varus deformity. Maintaining a systemic bone mass level may help to prevent the progression of knee varus deformity in the treatment of KOA.

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Relationships between cartilage thickness and subchondral bone mineral density in non-osteoarthritic and severely osteoarthritic knees: In vivo concomitant 3D analysis using CT arthrography

Cited by 23 publications

References 51 publications

Osteoarthritis year in review 2019: imaging

Osteoarthritis year in review 2019: imaging

Association between knee alignment, osteoarthritis disease severity, and subchondral trabecular bone microarchitecture in patients with knee osteoarthritis: a cross-sectional study

Osteoporosis is Associated with Varus Deformity in Postmenopausal Women with Knee Osteoarthritis: A Case-Control Study

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