Relationships between cobalamin, epidermal growth factor, and normal prions in the myelin maintenance of central nervous system

Scalabrino, Giuseppe; Veber, Daniela; Tredici, G

doi:10.1016/j.biocel.2014.09.011

Cited by 21 publications

(14 citation statements)

References 127 publications

(194 reference statements)

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“…However, one review did not find any evidence that the use of oral vitamin B 12 supplements is associated with improvement in the clinical symptoms of diabetic neuropathy 95 . Low central nervous system cobalamin levels may play a role in the development of multiple sclerosis 96, 97. Similar observations, and even reports on beneficial effects of vitamin B 12 injection therapy, have been reported in patients with myalgic encephalomyelitis, with and without fibromyalgia 98, 99.…”

Section: Just a Vitamin Or More?mentioning

confidence: 89%

The Many Faces of Cobalamin (Vitamin B12) Deficiency

Wolffenbuttel

Wouters

Heiner‐Fokkema

et al. 2019

Mayo Clinic Proceedings: Innovations, Quality & Outcomes

170

143

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Although cobalamin (vitamin B 12 ) deficiency was described over a century ago, it is still difficult to establish the correct diagnosis and prescribe the right treatment. Symptoms related to vitamin B 12 deficiency may be diverse and vary from neurologic to psychiatric. A number of individuals with vitamin B 12 deficiency may present with the classic megaloblastic anemia. In clinical practice, many cases of vitamin B 12 deficiency are overlooked or sometimes even misdiagnosed. In this review, we describe the heterogeneous disease spectrum of patients with vitamin B 12 deficiency in whom the diagnosis was either based on low serum B 12 levels, elevated biomarkers like methylmalonic acid and/or homocysteine, or the improvement of clinical symptoms after the institution of parenteral vitamin B 12 therapy. We discuss the possible clinical signs and symptoms of patients with B 12 deficiency and the various pitfalls of diagnosis and treatment.

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Section: Just a Vitamin Or More?mentioning

confidence: 89%

The Many Faces of Cobalamin (Vitamin B12) Deficiency

Wolffenbuttel

Wouters

Heiner‐Fokkema

et al. 2019

Mayo Clinic Proceedings: Innovations, Quality & Outcomes

170

143

View full text Add to dashboard Cite

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“…Paresthesia reflects an abnormality affecting the sensory pathways anywhere between the peripheral sensory nervous system and the sensory cortex 60,61 . Vitamin B12 (cobalamin) in the methylation process plays a role in myelination and remyelination 62,63 . Although small‐fiber neuropathy is associated with vitamin B 12 deficiency, 64 there is no evidence to support the direct effect of methylcobalamin on unmyelinated C fibers 65 .…”

Section: Discussionmentioning

confidence: 99%

Local Administration of Methylcobalamin for Subacute Ophthalmic Herpetic Neuralgia: A Randomized, Phase III Clinical Trial

et al. 2020

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Objectives: The ophthalmic branch of the trigeminal nerve is one of the most frequently involved sites of postherpetic neuralgia. A single-center randomized controlled study was conducted to evaluate the efficacy of local methylcobalamin injection for subacute ophthalmic herpetic neuralgia (SOHN). Methods: One hundred and five patients with a pain score of 4 or greater were randomized to receive a combination of methylcobalamin and lidocaine via local injection (LM group, n = 35), intramuscular methylcobalamin and local lidocaine injection (IM group, n = 35), and oral methylcobalamin tablet and lidocaine local injection (OM group, n = 35) for 4 weeks. Multilevel mixed modeling was employed to examine treatment responses. Results: Pain scores were reduced in all groups, but this reduction was significantly greater in the LM group (6.7 at baseline vs. 2.8 at endpoint) when compared with systemic administration (IM group 6.8 vs. 4.9, OM group 6.7 vs. 5.1). Clinically relevant reduction of pain (>30%) was seen in 91% of patients in the LM group, a significantly greater proportion than in the systemic groups (66% IM group, 57% OM group). Analgesic use reduced significantly in the LM group (94% at baseline vs. 6% at endpoint) but not in systemic groups (IM group 97% vs. 86%, OM group 94% vs. 80%). Health-related quality of life was higher in the LM group than in the systemic groups. In mixed modelling, increased age was associated with a lower response to methylcobalamin. Conclusions: This study indicates that local injection of methylcobalamin produces significant pain relief from SOHN and is superior to systemic administration. &

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“…In some serious cases, glucocorticoid suspensions may induce separation of the central ventricle or spinal cord aqueduct, which will lead to fatal intracranial hypertension [9]. Different agents of vitamin B 12 are used to inject into epidural space; however, it is unknown what would happen if vitamin B 12 was injected into the cerebrospinal fluid [10].…”

Section: Discussionmentioning

confidence: 99%

Inadvertent Application of a Drug Mixture into the Subarachnoid Space When Performing an Outward-Going Lumbar Intervertebral Foramina Injection

Nie¹

2016

WJNS

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An outward-going intervertebral foramina puncture along the side of lumbar vertebra spinous process was used to avoid infusing drugs into the subarachnoid space. However, we still had an inadvertent malpractice. The patient was diagnosed with lumbar discogenic lower back pain and was administrated an outward-going intervertebral foramina puncture through the side of lumbar vertebra spinous process (L5-S1). The drug mixture, containing triamcinolone acetonide suspension, cyanocobalamin and bupivacaine HCl, was injected. The patient had palpitations, chest tightness, dyspnea, bradycardia, and hypotension 3 min right after the injection. The vital signs gradually stabilized after treatment with atropine sulfate; however, he had complete sensorimotor loss below the level of distribution of the T2 spinal nerve. The cerebrospinal fluid pressure was lower in the subarachnoid space and the cerebrospinal fluid was slightly turbid and light pink in color. Six hours later, the sensory, motor, defecation, and urination functions returned to normal level. The patient had follow-up evaluations at 1, 3, and 6 months. The lumbar and hip pain was mild-to-severe at times as usual, but there were no other neurologic sequelae. Conclusions: This case showed that there is a risk that drugs may stray into the subarachnoid space during an outward-going intervertebral foramina puncture through the side of lumbar vertebral spinous process. The complication may occur due to a distal nerve root cyst. The result of triamcinolone acetonide suspension and cyanocobalamin injection into the cerebrospinal fluid was not as serious as we imagined.

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Relationships between cobalamin, epidermal growth factor, and normal prions in the myelin maintenance of central nervous system

Cited by 21 publications

References 127 publications

The Many Faces of Cobalamin (Vitamin B12) Deficiency

The Many Faces of Cobalamin (Vitamin B12) Deficiency

Local Administration of Methylcobalamin for Subacute Ophthalmic Herpetic Neuralgia: A Randomized, Phase III Clinical Trial

Inadvertent Application of a Drug Mixture into the Subarachnoid Space When Performing an Outward-Going Lumbar Intervertebral Foramina Injection

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