Relationships between computed tomography-assessed density, abdominal fat volume, and glucose metabolism after sleeve gastrectomy in Japanese patients with obesity

Ozeki, Yoshinori; Masaki, Takayuki; Yoshida, Yuichi; Okamoto, Mitsuhiro; Anai, Manabu; Gotoh, Koro; Endo, Yuichi; Ohta, Masayuki; Ito, Masafumi; Shibata, Hirotaka

doi:10.1507/endocrj.ej18-0543

Cited by 9 publications

(9 citation statements)

References 35 publications

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“…Moreover, loss of VAT post-surgery was associated with the changes in fasting glucose and HOMA-IR levels at 3 months post-surgery in the PCOS group and with the changes in TC at 12 months postsurgery in the control group. This finding was generally consistent with those from previous studies reporting that decreased VAT may contribute to the improvement of IR and lipid metabolism [18,33]. Further analyses were performed to explore the factors that may predict changes in body fat distribution in PCOS patients after LSG.…”

Section: Discussionsupporting

confidence: 90%

“…Moreover, pregnancy and fertility rates increased in PCOS patients with morbid obesity, after LSG surgery, with few maternal and neonatal complications [13,14]. It was reported that LSG was beneficial in the reduction of VAT mass in patients with obesity [15,16], which may help to reduce inflammatory adipokine secretion, decrease branched-chain amino acids levels, and improve IR [17,18]. However, limited data are available on the changes in body fat distribution (especially VAT) in PCOS patients with obesity after LSG surgery.…”

Section: Introductionmentioning

confidence: 99%

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The Changes in Body Composition in Obese Patients with Polycystic Ovary Syndrome after Laparoscopic Sleeve Gastrectomy:a 12-Month Follow-up

Cai

Gao

et al. 2021

OBES SURG

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Objectives To investigate the changes in body fat distribution and predicting factors of these changes in polycystic ovary syndrome (PCOS) patients with obesity, after laparoscopic sleeve gastrectomy (LSG). Methods This study consecutively enrolled 153 patients with obesity aged 18-45 years (83 with PCOS and 70 control patients) who underwent LSG from May 2013 to September 2020 at the Department of Endocrinology, Shanghai Tenth People's Hospital, with a 12-month follow-up. Dual-energy X-ray absorptiometry (DEXA) was used to assess body fat distribution. ResultsThe percentage of fat mass loss in the visceral adipose tissue (VAT) region (55.08%) was more than that in any other body regions at 12 months post-surgery in the PCOS group yet insignificant. Homeostatic model assessment of insulin resistance (HOMA-IR) at baseline and Δ HOMA-IR were only negatively correlated with the variations in VAT mass and volume at 3 months post-surgery in the PCOS group. Logistic regression analysis showed that HOMA-IR <6.65 was an independent predictive factor for the changes in VAT mass and volume at 3 months post-surgery in the PCOS group. Conclusions In this study, the percentage loss of fat mass was greater in the VAT region than in any other body regions in all patients. The rate of VAT decrease in the PCOS group was higher than that in the control group yet insignificant. Compared with control patients, HOMA-IR at baseline was an independent risk factor for the changes in VAT mass and volume at 3 months postsurgery in patients with PCOS. Key Points• The percentage loss of fat mass was greater in the VAT region than in any other body regions in all patients.• The rate of VAT decrease in the PCOS group was higher than that in the control group yet insignificant.• HOMA-IR at baseline was an independent risk factor for the changes of VAT mass in patients with PCOS.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

The Changes in Body Composition in Obese Patients with Polycystic Ovary Syndrome after Laparoscopic Sleeve Gastrectomy:a 12-Month Follow-up

Cai

Gao

et al. 2021

OBES SURG

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“…Obesity, especially visceral fat accumulation, secreted visfatin, interleukin-6, tumor necrosis factor Q, etc., cause insulin resistance [43] , which is one of the main reasons for atherosclerosis. At present, CT and MRI scans are the best methods for accurately evaluating visceral fat [44] . Domestic and foreign research results show that [45,46] a signi cant correlation exists between abdominal visceral fat and arteriosclerosis via CT scanning.…”

Section: Discussionmentioning

confidence: 99%

The relationship between the visceral adiposity index and carotid atherosclerosis in different genders and age groups

Cao

Liu

Yang

et al. 2021

Preprint

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Objective: We aimed to investigate the possible relationship between visceral adiposity index (VAI) and carotid atherosclerosis(CAS) in different genders and age groups in China. Methods: This study was an observational cross-sectional study and included 1996 participants who were health examination population .From January 2018 to June 2019, people over 18 years old who had physical examinations were included in the study. Each participant completed a standard questionnaire, anthropometric measurements, ultrasonic examination ,and provided blood samples for biochemical measurements. Regression models were utilized to evaluate the correlation between VAI and the CAS risk. An ROC curve was utilized to predict VAI diagnostic efficacy for carotid atherosclerosis. Result: After adjusting for potential risks, high-VAI subjects had an increased OR of having CAS in women aged>44 years[OR= 3.09,95% Confdence interval (95%CI)=1.64⑶5.82, p <0.001]. In females, the AUC and sensitivity specificity were [(0.595, 76.68% and 39.85%, all females), (0.575, 78.51% and 30.37%, age ≤44), (0.609, 84.71% and 40.46%, age >44). When compared with traditional obesity indices(BMI, WC, and HC) , the predictive ability of VAI was stronger in females >44.The same relationships in males were not signifcant. Conclusions: The VAI were associated with an increased risk of CAS,and it could be selected as new and simple predictors of CAS for middle-aged and elderly women(age >44)in China .

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“…4 Imaging myocardial functions by tissue Doppler (TD) echocardiography have disadvantages like angle dependence, limited spatial resolution, and one-dimensional deformation analysis. LSG is expected to affect many systems, especially the cardiovascular system, by decreasing body fat deposition to different degrees.…”

mentioning

confidence: 99%

“…LSG is expected to affect many systems, especially the cardiovascular system, by decreasing body fat deposition to different degrees. 4 Imaging myocardial functions by tissue Doppler (TD) echocardiography have disadvantages like angle dependence, limited spatial resolution, and one-dimensional deformation analysis. Recently, these limitations were overcome through advances in two-dimensional speckle tracking echocardiography (STE) and the superiority of STE over Doppler strain was established.…”

mentioning

confidence: 99%

Short‐ and mid‐term effects of sleeve gastrectomy on left ventricular function with two‐dimensional speckle tracking echocardiography in obese patients

et al. 2019

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Aim This study aimed to investigate left ventricular functions of obese patients with no known heart disease who underwent laparoscopic sleeve gastrectomy by speckle tracking echocardiography in their early and medium‐term postoperative follow‐up. Patients and Method Thirty‐seven obese patients (10 M, 27 F) without coronary artery disease or heart failure who had undergone LSG were included in the study. Apical four‐, three‐, and two‐chamber images were analyzed longitudinally by conventional methods and speckle tracking echocardiography (STE) for left ventricle functions preoperatively, at the postoperative Month 1 and at the postoperative Month 6 (QLAB 6.0), using current software. Results No difference was found between standard echocardiography and Doppler parameters in terms of the 1‐month versus 6‐month follow‐up values compared to baseline. Left ventricular STE longitudinal measurements demonstrated significantly higher longitudinal strain and strain velocity parameters in the follow‐up values at Month 6 compared to the values at Month 1 and at baseline. Global longitudinal strain (GLS) was −17.48 ± 1.09% in 6‐month follow‐up, −16.16 ± 1.26% in 1‐month follow‐up, and −16.06 ± 1.25% at baseline (P < .001). A significant correlation was found between delta GLS, which represents patients’ GLS change in 6 months, and delta weight, which represents patients’ body weight change in 6 months. Conclusion Obese patients who had undergone LSG were observed to have improved left ventricular function in the mid‐term.

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Relationships between computed tomography-assessed density, abdominal fat volume, and glucose metabolism after sleeve gastrectomy in Japanese patients with obesity

Cited by 9 publications

References 35 publications

The Changes in Body Composition in Obese Patients with Polycystic Ovary Syndrome after Laparoscopic Sleeve Gastrectomy:a 12-Month Follow-up

The Changes in Body Composition in Obese Patients with Polycystic Ovary Syndrome after Laparoscopic Sleeve Gastrectomy:a 12-Month Follow-up

The relationship between the visceral adiposity index and carotid atherosclerosis in different genders and age groups

Short‐ and mid‐term effects of sleeve gastrectomy on left ventricular function with two‐dimensional speckle tracking echocardiography in obese patients

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