Relationships Between Depressive Symptoms, Dietary Inflammatory Potential, and Sarcopenia: Mediation Analyses

Chen, Guoqiang; Wang, Gang-Pu; Lian, Ying

doi:10.3389/fnut.2022.844917

Cited by 12 publications

(9 citation statements)

References 43 publications

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“…Secondly, depression data and LPA assessment in our study were based on self–reported questionnaire. However, PHQ9 and PAQ were regarded as “gold standard” criteria for large population–based studies, which has been applied in several previous publications ( 75 , 76 ). In addition, DII score calculated by 24–h dietary recall may not only cause imprecise estimates due to inability in measuring day–to–day variability in dietary intake, but also characterize population or group intake rather than a measure of individual intake ( 77 ).…”

Section: Discussionmentioning

confidence: 99%

Relationship between leisure-time physical activity and depressive symptoms under different levels of dietary inflammatory index

et al. 2022

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Depressive symptoms are major public health problems. Leisure-time Physical activity (LPA) and dietary inflammatory preference are emerging factors that tends to affect the mental health status. There is limited evidence regarding the joint influence of LPA and dietary status on the prevalence of depression. This study was a cross-sectional study, which used a nationwide represented sample from the National Health and Nutrition Examination Survey (NHANES) to assess the relationship among LPA, diet status and depression. Depression and LPA status was reported by the 9-item Patient Health Questionnaire (PHQ-9) and Physical Activity Questionnaire (PAQ), respectively. To assess dietary inflammatory preferences, dietary inflammatory index (DII) was applied based on a 24-h dietary recall interview. A total of 11,078 subjects was included in this study and weighted participants were 89,682,020. Weighted multivariable linear regression showed that DII was negatively associated with LPA after full adjustment, with β (95% CI): −0.487 (−0.647, −0.327). Weighted multivariable logistic regression showed that LPA was significantly associated with depressive symptoms after full adjustment, with odds ratios OR (95% CIs): 0.986 (0.977, 0.995). By DII stratification analysis, this phenomenon was also existed in groups with anti-inflammatory diet. Mediation effect analysis was further performed, which showed that DII significantly mediating the association between LPA and depression with proportion mediated as 3.94%. Our findings indicated the mediating role of DII in the association between LPA condition and incident depression. More well-designed studies are still needed to validate the causal relationship.

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Section: Discussionmentioning

confidence: 99%

Relationship between leisure-time physical activity and depressive symptoms under different levels of dietary inflammatory index

et al. 2022

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“…For dose-response meta-analysis, we included seven studies that divided DII into at least three categories, and two studies were excluded ( 23 , 44 ). Setting the reference DII level as −2.68, we found a significant non-linear dose-response relationship between DII and sarcopenia ( P = 0.012 for non-linearity).…”

Section: Resultsmentioning

confidence: 99%

The association of dietary inflammatory potential with skeletal muscle strength, mass, and sarcopenia: a meta-analysis

Xie

Wang

et al. 2023

Front. Nutr.

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AimsEvidence suggested that dietary inflammatory potential may be associated with age-related skeletal muscle decline, but the results remained controversial. To summarize the evidence for the relationships between dietary inflammatory potential and skeletal muscle strength, mass, and sarcopenia in adults we conducted this meta-analysis.MethodsEmbase, Pubmed, and Web of Science were searched from inception up to 12 March 2023 for studies that evaluated the associations of dietary inflammatory potential [estimated by the Dietary inflammatory index (DII)] with skeletal muscle strength, mass, and sarcopenia. A meta-analysis was then performed to calculate the pooled regression coefficient (β) and odds ratio (OR). The non-linear dose-response relation between DII and sarcopenia was assessed using random-effects dose-response meta-analysis.ResultsThis meta-analysis included 24 studies involving 56,536 participants. It was found that high DII was associated with low skeletal muscle strength [OR 1.435, 95% confidence interval (CI) 1.247–1.651, P < 0.001, I2 = 4.97%]. There was a negative association of DII with skeletal muscle strength (β−0.031, 95% CI −0.056 to −0.006, P = 0.017, I2 = 72.69%). High DII was also associated with low skeletal muscle mass (OR 1.106, 95% CI 1.058–1.157, P < 0.001, I2 = 0%). DII had a negative relationship with skeletal muscle mass with high heterogeneity (β−0.099, 95% CI −0.145 to −0.053, P < 0.001, I2 = 88.67%); we downgraded the inconsistency in the subgroup analysis of overweight/obese participants (β−0.042, 95% CI −0.065 to −0.019, I2 = 12.54%). Finally, the pooled results suggested that high DII was significantly associated with sarcopenia with significant heterogeneity (OR 1.530, 95% CI 1.245–1.880, P < 0.001, I2 = 69.46%); age and BMI may contribute partially to the heterogeneity since heterogeneity was decreased in the subgroup of older age (OR 1.939, 95% CI 1.232–3.051, I2 = 0%) and the group of overweight/obesity (OR 1.853, 95% CI 1.398–2.456, I2 = 0%). There was a non-linear dose-response association between DII and sarcopenia (P = 0.012 for non-linearity).ConclusionThis meta-analysis suggested that higher dietary inflammatory potential was significantly associated with lower skeletal muscle strength, mass, and risk of sarcopenia. Future studies with consistent assessment and standardized methodology are needed for further analysis.

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“…This provides us with a macro dietary direction to prevent and control sarcopenia, which reduces the total incidence of sarcopenia in the population by increasing the intake of anti-inflammatory diets. At the same time, a mediation analysis [ 26 ] showed that the DII and depressive symptoms are related to sarcopenia. Symptoms of depression play a significant mediating role on the related manifestations of the DII and sarcopenia (muscle strength, muscle mass, and physical performance).…”

Section: Discussionmentioning

confidence: 99%

“… Forest plot of the risk of sarcopenia in subjects with a high DII vs. a low DII [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ]. …”

Section: Figurementioning

confidence: 99%

Association between Dietary Inflammatory Index and Sarcopenia: A Meta-Analysis

Diao

Yan

et al. 2023

Nutrients

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Background: The dietary inflammatory index (DII) is thought to be related to many healthy events. However, the association between the DII and sarcopenia remains unclear. Methods: The meta-analysis was conducted to evaluate the effects of the DII on the risk of sarcopenia utilizing available studies. Up to September 2022, Cochrane, PubMed, Web of Science, Medline, and EMBASE databases were searched to evaluate the relationships between the DII and sarcopenia. A random‒effects model was used to calculate the effect size and 95% confidence intervals (CIs). Result: Eleven studies with 19,954 participants were included in our meta-analysis. The results indicated that a high DII increased the risk of sarcopenia (OR = 1.16, 95%CI [1.06, 1.27], p < 0.05). The result of the dose–response analysis showed that the risk of sarcopenia increased by 1.22 times for each 1-point increase in the DII score (OR = 1.22, 95%CI [1.12, 1.33], p < 0.05). Conclusion: The meta-analysis demonstrated that the DII is associated with sarcopenia. Considering some limitations in this study, more studies are needed to verify this relationship.

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Relationships Between Depressive Symptoms, Dietary Inflammatory Potential, and Sarcopenia: Mediation Analyses

Cited by 12 publications

References 43 publications

Relationship between leisure-time physical activity and depressive symptoms under different levels of dietary inflammatory index

Relationship between leisure-time physical activity and depressive symptoms under different levels of dietary inflammatory index

The association of dietary inflammatory potential with skeletal muscle strength, mass, and sarcopenia: a meta-analysis

Association between Dietary Inflammatory Index and Sarcopenia: A Meta-Analysis

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