Relationships Between<i>p16</i>Gene Promoter Methylation and Clinicopathologic Features of Colorectal Cancer: A Meta-Analysis of 27 Cohort Studies

Chen, Yanzhi; Liú, Dan; Zhao, Yang; Wang, He-Tong; Gao, Ya; Chen, Ying

doi:10.1089/dna.2013.2253

Cited by 6 publications

(4 citation statements)

References 66 publications

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“…And the patients with CRC with p16 protein negative expression would have a bigger chance of lymph node metastasis in tumor cells. And these results were consistent with the founding of Chen et al [ 76 ] They also found that p16 gene promoter hypermethylation was significantly associated with the TNM stage and Dukes stage of patients with CRC. Therefore, p16 gene promoter hypermethylation might repress the activity of p16 protein, which promoted differentiation of tumor cells and aggravated the progression of CRC.…”

Section: Discussionsupporting

confidence: 92%

“…For instance, the status of p16 gene promoter methylation was commonly studied and significantly associated with the development of bladder cancer, lung cancer, brain cancer, and esophagus cancer. [ 72 – 75 ] At the same time, the study of Chen et al [ 76 ] has suggested that promoter hypermethylation of the p16 gene might be significantly associated with the clinicopathologic features of CRC. However, an accurate expression level of p16 gene was not detected in these studies despite the significant impact of p16 promoter hypermethylation on p16 protein expression.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic and clinicopathological value of p16 protein aberrant expression in colorectal cancer

Zhou¹,

Gu²

2018

Medicine

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Purpose:Several studies have examined the potential role of p16 protein expression as a diagnostic and prognostic biomarker in various cancers. However, it remains unclear whether p16 protein expression is a prognostic and diagnostic factor for colorectal cancer. Therefore, this meta-analysis is conducted to evaluate the associations of p16 protein expression with overall survival (OS) and clinicopathological characteristics of colorectal cancer.Methods:According to PRISMA guideline, relevant literatures were identified by searching Medicine, Web of Science, WanFang, and CNKI databases. The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were extracted from included studies to assess the association between p16 protein expression and OS of patients with colorectal cancer. Other relevant data were extracted to evaluate the correlations of p16 protein expression with risk and clinicopathological characteristics of colorectal cancer. Stata 12.0 software was applied to calculate the strength of association between p16 protein expression and colorectal cancer.Results:Forty-one studies were included to evaluate the association between p16 protein expression and colorectal cancer. Nine studies involving 1731 patients with colorectal cancer found that there was no association between p16 protein expression and OS of colorectal cancer in the overall analysis (HR = 0.78, 95% CI: 0.55–1.10). However, p16 protein overexpression was significantly associated with a better prognosis in patients with colorectal cancer when cut-off value of p16 protein expression was <10% (HR = 0.23, 95% CI: 0.08–0.66). The results of subgroup analysis based on ethnicity indicated that p16 protein overexpression was a risk factor for the occurrence of colorectal cancer in Caucasians (odds ratio = 28.95, 95% CI: 6.08–137.89), but not in Asians. Furthermore, p16 protein overexpression was significantly associated with the Dukes stage, lymph node metastasis, tumor location, and Tumor Lymph Node Metastasis-stage of colorectal cancer.Conclusions:p16 protein overexpression might be a useful biomarker to predict the clinicopathological progress and prognosis of colorectal cancer.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Prognostic and clinicopathological value of p16 protein aberrant expression in colorectal cancer

Zhou¹,

Gu²

2018

Medicine

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“…With regards to p16 expression, there is a recent metaanalysis (40), that associates various clinico-pathological features with the deregulation of its promoter via methylation. In our cohort, there is a trend towards higher p16 expression in M b-catenin (21.66 vs. 10.25 vs. 5.00, p=0.028).…”

Section: Discussionmentioning

confidence: 99%

KRAS Mutant Status May Be Associated with Distant Recurrence in Early-stage Rectal Cancer

Sideris

Moorhead

Díaz‐Cano

et al. 2017

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“…The p16 INK4a protein is a cyclin-dependent kinase inhibitor that can act on cyclin-dependent kinases(CDKs) and thus inactivate the cell cycle[ 8 ].The loss of p16ink4a expression seems to be an early event in carcinogenesis. Over the past decades, the prognostic value of p16 INK4a protein has been evaluated in a wide variety of cancers [ 9 – 14 ].Among these, the study of Hellman et al[ 15 ] concluded that p16 INK4A expression might be used as a marker for HPV positivity in vaginal carcinoma, which shares a very similar etiology with vulvar cancer. However, its role and the etiological effect of its combination with the HPV status in vulvar cancer remain somehow unclear.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Value of Overexpressed p16INK4a in Vulvar Cancer: A Meta-Analysis

et al. 2016

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ObjectiveThis study aimed to examine the prognostic value of overexpressed p16INK4a in vulvar cancer. Although the tumor suppressor p16INK4a has been shown to be of prognostic value in a wide variety of cancers and precancerous lesions, its role in the vulvar cancer is still unclear.MethodsAll publications in English language on the association between p16INK4a and clinicopathological features of vulvar cancer were searched from Pubmed, Embase, and Web of Science, and those in Chinese language were identified manually and online from the China National Knowledge Infrastructure. Strict inclusion and exclusion criteria were followed. Odds ratios(ORs) or risk ratios(RRs) with 95% confidence intervals(CIs) were pooled to assess the strength of association. Publication bias was estimated using funnel plots and the Egger’s regression test.ResultsA total of 17 studies with 2309 patients were included. The p16INK4a overexpression was found to correlate significantly with the lower International Federation of Gynecology and Obstetrics stage(I+II vs III+IV; OR = 0.60,95%CI:0.41–0.86,P = 0.006),negative lymph node metastasis(negative vs positive; OR = 0.61,95%CI:0.39–0.95,P = 0.029),patient’s age<55(OR = 0.54,95%CI:0.31–0.96,P = 0.034),human papillomavirus–positive status(OR = 0.01,95%CI:0.00–0.11,P<0.001),and higher overall survival(RR = 0.53,95%CI = 0.35–0.80,P = 0.003).ConclusionThe p16INK4a might be associated with a higher survival and indicates better prognosis of vulvar cancer.

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Relationships Betweenp16Gene Promoter Methylation and Clinicopathologic Features of Colorectal Cancer: A Meta-Analysis of 27 Cohort Studies

Cited by 6 publications

References 66 publications

Prognostic and clinicopathological value of p16 protein aberrant expression in colorectal cancer

Prognostic and clinicopathological value of p16 protein aberrant expression in colorectal cancer

KRAS Mutant Status May Be Associated with Distant Recurrence in Early-stage Rectal Cancer

Prognostic Value of Overexpressed p16INK4a in Vulvar Cancer: A Meta-Analysis

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