Relationships between leptin, insulin, IGF-1 and IGFBP-3 in children with energy malnutrition

Haspolat, Kenan; Ece, Aydın; Gürkan, Fuat; Atamer, Yıldız; Tutanç, Murat; Yolbaş, İlyas

doi:10.1016/j.clinbiochem.2006.11.008

Cited by 45 publications

(36 citation statements)

References 21 publications

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“…In these studies on protein-calorie malnourished children, serum leptin levels were found to be lower than healthy subjects (2,11,12,14,15). Serum leptin concentrations fall rapidly in response to complete fasting and out of proportion to changes in fat mass.…”

Section: Discussionmentioning

confidence: 99%

“…This fat mass catabolism may be partly responsible from the increased triglyceride levels of marasmic children, since fatty acids and triglyceride are released into circulation during lipolysis (25). In marasmus there is also hypoinsulinemia (2,14) and insulin is the most important activator of lipoprotein lipase (LPL) (23). Some authors have shown LPL deficiency in PEM (26,27).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore we suggested a possible relationship between leptin and oxidation processes in a clinical example of children with nephrotic syndrome (13). In studies related to childhood malnutrition, generally very low leptin levels (2,11,14,15) and increased oxidant stress have been reported (5)(6)(7)(8), however up to date no previous study has investigated leptin and erythrocyte oxidant stress markers together.…”

Section: Introductionmentioning

confidence: 99%

“…Clinically, marasmus is characterized by severe deficit of body mass, results from inadequate energy intake (1)(2)(3)(4).…”

Section: Introductionmentioning

confidence: 99%

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Oxidative Stress in Marasmic Children: Relationships with Leptin

et al. 2010

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Clinically, marasmus is characterized by severe deficit of body mass, results from inadequate energy intake (1)(2)(3)(4).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Oxidative Stress in Marasmic Children: Relationships with Leptin

et al. 2010

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“…Além disso, assim como em outros estudos 20 , foram observados níveis significativamente menores de IGF-1 no grupo DPE se comparado aos controles. A diminuição na ingestão energética e proteica, no tecido adiposo e nos níveis séricos de IGF-1 em crianças com DPE pode resultar em redução na secreção de leptina, o que possivelmente leva ao início da ingestão de alimentos ao aumentar o apetite e estimular a secreção de cortisol e GH, com aumento significativo nos níveis basais de GH 15 .…”

Section: Discussionunclassified

Growth hormone/insulin-like growth factor-1 axis: a possible non-nutritional factor for growth retardation in children with cerebral palsy

Hegazi¹,

Soliman²,

Hasaneen³

et al. 2012

J Pediatr (Rio J)

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Objective: To assess growth hormone (GH)/insulin like growth factor-1 (IGF-1) axis as a possible non-nutritional factor for growth retardation in children with cerebral palsy (CP). Methods:A case-control study was conducted at a tertiary university hospital. Thirty children with CP (seven children with normal growth [CP-N] and 23 with retarded growth [CP-R]), 30 children with protein energy malnutrition (PEM), and 30 healthy children (REF group) underwent an assessment of growth parameters, serum IGF-1, basal GH, and peak GH after stimulation with insulin.Results: PEM patients had higher basal GH levels than CP-N, CP-R and REF groups (p = 0.026, p < 0.001, and p < 0.001 respectively). After insulin stimulation, CP-N, CP-R, and PEM patients had lower GH levels compared to the REF group (p = 0.04, p = 0.007, and p = 0.036 respectively). IGF-1 levels were lower in CP-R group compared to CP-N and REF groups (p = 0.037 and p < 0.001 respectively), and in PEM group compared to CP-N and REF groups (p < 0.001 and p < 0.001 respectively). Conclusions:CP-R patients failed to demonstrate the same high basal GH response as PEM patients, and responded inadequately to the insulin stimulation test, but they had IGF-1 levels comparable to those of PEM patients. On the other hand, CP-N patients behaved as controls regarding their basal GH and IGF-1 levels, but failed to respond adequately to the insulin stimulation test. The PEM group presented high basal GH and low IGF-1 levels. These findings suggest that nonnutritional factors contribute to growth retardation in CP children. J Pediatr (Rio J). 2012;88(3):267-74:GH, IGF-1, cerebral palsy, children. ResumoObjetivo: Avaliar o eixo hormônio de crescimento (GH)/fator de crescimento semelhante à insulina 1 (IGF-1) como possível fator não nutricional para o retardo de crescimento em crianças com paralisia cerebral (PC). Conclusões:Os pacientes com PC-R não demonstraram a mesma resposta basal elevada do GH apresentada pelos pacientes com DPE, e responderam de forma inadequada ao estímulo com insulina, mas apresentaram níveis de IGF-1 comparáveis aos dos pacientes com DPE. Por outro lado, os pacientes com PC-N tiveram comportamento semelhante ao dos controles com relação aos níveis basais de GH e IGF-1, mas não responderam adequadamente ao estímulo com insulina. O grupo DPE apresentou GH basal elevado e IGF-1 baixo. Esses achados sugerem que fatores não nutricionais contribuem para o retardo de crescimento em crianças com PC. Growth hormone/insulin-like growth factor-1 axis: a possible non-nutritional factor for growth retardation in children with cerebral palsy Não foram declarados conflitos de interesse associados à publicação deste artigo.Como citar este artigo: Hegazi MA, Soliman OE, Hasaneen BM, El-Arman M, El-Galel NA, El-Deek BS. Growth hormone/insulin-like growth factor-1 axis: a possible non-nutritional factor for growth retardation in children with cerebral palsy. J Pediatr (Rio J). 2012;88(3):267-74.Artigo submetido em 27.11.11, aceito em 14.03.12.http://dx

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Multiple endocrine neoplasia type 2B: Frequency of physical stigmata—Results of the GPOH‐MET registry

Redlich

Lessel

Petrou

et al. 2019

Pediatric Blood & Cancer

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BackgroundMultiple endocrine neoplasia (MEN) 2B is characterized by early development of aggressive medullary thyroid carcinoma (MTC), visible physical stigmata, and associated symptoms. In most cases, de novo mutations are revealed. There are premonitory symptoms and stigmata that enable early diagnosis, before an inoperable MTC develops. The German Society for Paediatric Oncology and Haematology (GPOH)—Malignant Endocrine Tumours (MET) registry maintains records of children with MTC in Germany since 1997.MethodsChildren with a diagnosis of MTC in MEN 2B recorded in the GPOH‐MET study were analyzed retrospectively. Stigmata and symptoms associated with MEN 2B were examined.ResultsFrom inception through 2017, 24 patients aged 0.2‐17.3 years were included. Symptoms affecting the oral/dental (88.0%), musculoskeletal (79.2%), and gastrointestinal (70.8%) systems were recognized most frequently. Gastrointestinal and musculoskeletal symptoms preceded symptoms of MTC. Twelve patients had short stature. Regarding the prevalence of single symptoms, neuromas of the lips and the oral cavity were mentioned most frequently. Five patients died from MTC. Patients diagnosed by tumor symptoms showed more advanced disease than those with disease detected by other means. Children diagnosed via associated stigmata and symptoms or positive family history had significantly improved overall survival (OS) compared to children diagnosed via symptoms of MTC (OS 100% vs 53.3%).ConclusionsIn children with MEN 2B, oral/dental, musculoskeletal, and gastrointestinal symptoms are most common. If children are diagnosed via associated symptoms and stigmata, OS is improved. Most of the children were diagnosed with growth disturbances; this finding requires verification and ranging in other patient cohorts.

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Relationships between leptin, insulin, IGF-1 and IGFBP-3 in children with energy malnutrition

Cited by 45 publications

References 21 publications

Oxidative Stress in Marasmic Children: Relationships with Leptin

Oxidative Stress in Marasmic Children: Relationships with Leptin

Growth hormone/insulin-like growth factor-1 axis: a possible non-nutritional factor for growth retardation in children with cerebral palsy

Multiple endocrine neoplasia type 2B: Frequency of physical stigmata—Results of the GPOH‐MET registry

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