Relationships Between Low-Density Lipoprotein Particle Size, Plasma Lipoproteins, and Progression of Coronary Artery Disease

Vakkilainen, Juha; Steiner, George; Ansquer, Jean-Claude; Aubin, F.; Rattier, Stephanie; Foucher, Christelle; Hamsten, Anders; Taskinen, Marja‐Riitta

doi:10.1161/01.cir.0000057982.50167.6e

Cited by 241 publications

(35 citation statements)

References 35 publications

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“…Recent studies have found that plasma sd-LDL levels were influenced by other risk factors such as gender, age, glucose, body mass index and conventional lipid parameters [19, 21, 27]. In our study, multiple stepwise regression analysis showed that sd-LDL was significantly and positively associated with TG, systolic blood pressure, and history of DM, with strong negative correlations with HDL cholesterol (RC = 6.21) as well as LDL cholesterol (RC = 2.07).…”

Section: Discussionmentioning

confidence: 99%

Small Dense Low-Density Lipoproteins and Associated Risk Factors in Patients with Stroke

Zhao¹,

Cui²,

Fan³

et al. 2008

Cerebrovasc Dis

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Objective: Low-density lipoproteins (LDL) are a heterogeneous group of particles, with small, dense particles being more atherogenic. It remains controversial whether elevated plasma levels of small dense LDL (sd-LDL) are risk factors for stroke. The aim of the present study was to examine the plasma levels of sd-LDL in patients with stroke and to investigate the associations in a large Chinese case-control study. Methods: We recruited 299 stroke patients (159 cerebral thrombosis, 42 lacunar infarction, 98 intracerebral hemorrhage) and 299 controls. The semiquantitative analysis of plasma levels of sd-LDL was performed by nondenaturing gradient gel electrophoresis. Results: (1) The plasma levels of sd-LDL in patients with ischemic stroke or hemorrhagic stroke were higher than in controls. (2) Multiple regression analysis showed that there were significant relationships between sd-LDL and triglyceride, high-density lipoprotein cholesterol, LDL cholesterol, systolic blood pressure and history of diabetes, and a significant relationship between sd-LDL and stroke (r = 0.286, p < 0.001) even after adjusting for these factors. (3) Compared with the controls, the calculation of odds ratios indicated relative risk estimates of 3.111 for ischemic stroke (OR = 3.111 , 95% CI = 1.891–5.117, p < 0.001) and 3.164 for hemorrhagic stroke (OR = 3.164, 95% CI = 1.632–6.137, p < 0.01). Conclusion: Plasma sd-LDL was independently associated with both thrombotic and hemorrhagic stroke, suggesting it may be an independent predictor of as well as a risk factor for stroke in Chinese people, justifying clinical trials for primary and secondary prevention of stroke using statins or fibrates.

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Section: Discussionmentioning

confidence: 99%

Small Dense Low-Density Lipoproteins and Associated Risk Factors in Patients with Stroke

Zhao¹,

Cui²,

Fan³

et al. 2008

Cerebrovasc Dis

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“…Compared with placebo, fenofibrate treatment significantly increased LDL particle size and HDL cholesterol and decreased plasma total cholesterol, LDL cholesterol, and triglyceride concentrations. The final LDL particle size was inversely correlated with the increase in percentage diameter stenosis (Vakkilainen et al, 2003).…”

Section: Relationship Between Insulin Resistance Diabetes and Smallmentioning

confidence: 93%

“…These changes in the NMR lipoprotein subclass profile predictably increased the risk of cardiovascular disease but were not fully apparent in the conventional lipid profile (Garvey et al, 2003). The Diabetes Atherosclerosis Intervention Study (DAIS) (Vakkilainen et al, 2003) showed that lipid-modifying treatment decreased the angiographic progression of coronary atherosclerosis in subjects with type 2 diabetes. This effect was related in part to the correction of lipoprotein abnormalities.…”

Section: Relationship Between Insulin Resistance Diabetes and Smallmentioning

confidence: 99%

Lipoproteins and Cardiovascular Diseases

Saba¹,

Oridupa²

2012

Lipoproteins - Role in Health and Diseases

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“…In general, LDL particles can be subfractionated into buoyant, intermediate, and dense LDLs. In vitro experiments (3)(4)(5) and epidemiologic studies (6)(7)(8)(9)(10)(11)(12) have shown that buoyant LDLs (12) and particularly dense LDLs (6)(7)(8)(9)(10)(11) are more atherogenic than intermediate LDLs. Such findings may be partly explained by the association of dense LDLs with increased levels of plasma triglycerides and decreased levels of HDL-cholesterol (8).…”

mentioning

confidence: 99%

In vivo metabolism of LDL subfractions in patients with heterozygous FH on statin therapy

Geiss

Bremer

Barrett

et al. 2004

Journal of Lipid Research

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LDL can be subfractionated into buoyant (1.020-1.029 g/ml Ϫ 1 ), intermediate (1.030-1.040 g/ml Ϫ 1 ), and dense (1.041-1.066 g/ml Ϫ 1 ) LDLs. We studied the rebound of these LDL-subfractions after LDL apheresis in seven patients with heterozygous familial hypercholesterolemia (FH) regularly treated by apheresis (58 Ϯ 9 years, LDL-cholesterol ϭ 342 Ϯ 87 mg/dl Ϫ 1 , triglycerides ϭ 109 Ϯ 39 mg/ dl Ϫ 1 ) and high-dose statins. Apolipoprotein B (apoB) concentrations were measured in LDL subfractions immediately after and on days 1, 2, 3, 5, and 7 after apheresis. Compartmental models were developed to test three hypotheses: 1) that dense LDLs are derived from the delipidation of buoyant and intermediate LDLs (model A); 2) that dense LDLs are generated directly from LDL-precursors (model B); or 3) that a model combining both pathways (model C) is necessary to describe the metabolism of dense LDLs. In all models, it was assumed that apoB production and fractional catabolic rate (FCR) did not change with apheresis. Apheresis decreased buoyant, intermediate, and dense LDL-apoB by 60 Ϯ 12%, 67 Ϯ 5%, and 69 Ϯ 11%, respectively. Models B and C, but not model A, described the rebound data. The model with the greatest biological plausibility (model C) was used to estimate metabolic parameters.

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Relationships Between Low-Density Lipoprotein Particle Size, Plasma Lipoproteins, and Progression of Coronary Artery Disease

Cited by 241 publications

References 35 publications

Small Dense Low-Density Lipoproteins and Associated Risk Factors in Patients with Stroke

Small Dense Low-Density Lipoproteins and Associated Risk Factors in Patients with Stroke

Lipoproteins and Cardiovascular Diseases

In vivo metabolism of LDL subfractions in patients with heterozygous FH on statin therapy

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