Relationships between neuropsychological performance, insight, medication adherence, and social metacognition in schizophrenia

Roux, Paul; Faivre, Nathan; Urbach, M.; Aouizerate, Bruno; Brunel, L.; Capdevielle, Delphine; Chéreau, Isabelle; Dubertret, Caroline; Dubreucq, Julien; Fond, Guillaume; Lançon, Christophe; Leignier, Sylvain; Mallet, J.; Misdrahi, D.; Pires, S.; Schneider, Priscille; Schürhoff, Franck; Yazbek, Hanan; Zinetti-Bertschy, A.; Passerieux, Christine; Brunet-Gouet, Éric

doi:10.1016/j.schres.2022.12.037

Cited by 3 publications

(2 citation statements)

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“… 14 However, a previous study in patients with schizophrenia admitted to hospital within 2 years of initial diagnosis reported a treatment success rate of 64.3% for patients with a positive DA and who consistently received drug treatment. 7 In addition, Hsieh et al reported that DA directly affects MA in individuals with schizophrenia residing in the community, 15 and previous several studies suggest that a positive DA can increase MA rates. 8 , 16 Thus, to improve MA in patients with schizophrenia, healthcare professionals should adopt a personalized medication education approach that considers individual DA, and health providers for patients with early psychosis should aim to increase DA to raise MA and ultimately improve patients’ quality of life.…”

Section: Introductionmentioning

confidence: 96%

“…Typically, nonadherence with drug therapy is reported as 40% within 1 year, and 75% within 2 years. 6 Such nonadherence leads to significant social and psychological consequences and to a major influence on the disease; [7][8][9] therefore, it is particularly important to help patients with early psychosis engage in successful drug therapy to prevent remission and chronicity.…”

Section: Introductionmentioning

confidence: 99%

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Drug Attitude and Medication Adherence of Patients with Early Psychosis in South Korea: Mediating Effect of Medication Adherence Self-Efficacy

Choi¹,

Kweon²

2023

PPA

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Purpose This study examined the mediating effect of medication adherence self-efficacy (MASE) on the relationship between drug attitude (DA) and medication adherence (MA) in patients with early psychosis. Patients and Methods A total of 166 patients, aged 20 years or older, and who had received treatment within 5 years of their initial psychotic episode at a University Hospital outpatient center, participated in the study. Data were analyzed using descriptive statistics, t -tests, one-way analysis of variance, Pearson’s correlation coefficients, and multiple linear regression. Additionally, a bootstrapping test was conducted to determine the statistical significance of the mediating effect. All study procedures adhered to Strengthening the reporting of observational studies in epidemiology (STROBE) guidelines. Results This study found a significant correlation between MA and DA (r=0.393, p<0.001), and between MA and MASE (r=0.697, p<0.001). MASE had a partial mediating effect on the association between DA and MA. The model that integrated both DA and MASE accounted for 53.4% of the variation in MA. Bootstrapping analysis indicated that MASE was a significant partial parameter (lower limit confidence interval [CI] 0.114; upper limit CI 0.356). Further, 64.5% of the study participants were either currently enrolled in college or had higher levels of education. Conclusion These findings could potentially lead to a more personalized approach to medication education and adherence, considering the unique DA and MASE of each patient. By identifying the mediating effect of MASE on the relationship between DA and MA, healthcare providers could tailor interventions to enhance the ability of patients with early psychosis to adhere to prescribed medication regimens.

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Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Drug Attitude and Medication Adherence of Patients with Early Psychosis in South Korea: Mediating Effect of Medication Adherence Self-Efficacy

Choi¹,

Kweon²

2023

PPA

View full text Add to dashboard Cite

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Why using “consciousness” in psychotherapy? Insight, metacognition and self-consciousness

Martin

2023

New Ideas in Psychology

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Confidence in visual detection, familiarity and recollection judgments is preserved in schizophrenia spectrum disorder

Rouy,

Pereira,

Saliou

et al. 2023

Schizophr

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An effective way to quantify metacognitive performance is to ask participants to estimate their confidence in the accuracy of their response during a cognitive task. A recent meta-analysis1 raised the issue that most assessments of metacognitive performance in schizophrenia spectrum disorders may be confounded with cognitive deficits, which are known to be present in this population. Therefore, it remains unclear whether the reported metacognitive deficits are metacognitive in nature or rather inherited from cognitive deficits. Arbitrating between these two possibilities requires equating task performance between experimental groups. Here, we aimed to characterize metacognitive performance among individuals with schizophrenia across three tasks (visual detection, familiarity, recollection) using a within-subject design while controlling experimentally for intra-individual task performance and statistically for between-subject task performance. In line with our hypotheses, we found no metacognitive deficit for visual detection and familiarity judgments. While we expected metacognition for recollection to be specifically impaired among individuals with schizophrenia, we found evidence in favor of an absence of a deficit in that domain also. We found no specific metacognitive deficit in schizophrenia spectrum disorder in the visual or memory domain. The clinical relevance of our findings is discussed in light of a hierarchical framework of metacognition.

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Relationships between neuropsychological performance, insight, medication adherence, and social metacognition in schizophrenia

Cited by 3 publications

References 45 publications

Drug Attitude and Medication Adherence of Patients with Early Psychosis in South Korea: Mediating Effect of Medication Adherence Self-Efficacy

Drug Attitude and Medication Adherence of Patients with Early Psychosis in South Korea: Mediating Effect of Medication Adherence Self-Efficacy

Why using “consciousness” in psychotherapy? Insight, metacognition and self-consciousness

Confidence in visual detection, familiarity and recollection judgments is preserved in schizophrenia spectrum disorder

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