Relationships between occupational history and serum concentrations of organochlorine compounds in exocrine pancreatic cancer

Abstract

Certain occupations were associated with higher concentrations of PCBs, suggesting that these compounds may account for some increased risks found in previous studies. The lack of association between work in agriculture and concentrations of OC pesticides is consistent with occupation playing a lesser role than diet in influencing OC concentrations. Occupational studies on the relationships among exposure to industrial agents and EPC risk may need to consider adjusting for exposure to PCBs.

Exposición laboral a hidrocarburos clorados y cáncer de páncreas: revisión de la bibliografía reciente

“…No high serum levels of organochlorines were found in agriculture workers, which was a novelty, since other studies have linked with the occurrence of cancer pancreas 1 . Cocco et al reported no differences in risk between the group exposed and not exposed to DDT 15. This result contrasts with the findings of Beard et al that coincide with most of the previous studies that found an association between pancreatic cancer risk and exposure to DDT 16 .…”

“…This appears to be associated with tobacco consumption and obesity, which may be modifiable risk factors, although there may be other factors concerning which there is no proven evidence that should be studied in order to also act on them. The high lethality of exocrine pancreatic cancer further underscores the need to identify risk factors suitable for primary prevention [1][2][3] .…”

“…3,4 traditionally occupations that have been associated with increased risk of pancreatic cancer include: printing and paper manufacturing, chemical, petroleum and rubber industries, transport, dry cleaning, leather tanning, transformer manufacturing plants, the production of pesticides, mechanic and metallurgical occupations, as well as miners, shotfires, stone cutters and carvers, machinery mechanics and fitters, building trades workers and motor vehicle drivers in men, office clerks in women and waiters in both sexes 1,3,7,10,11 . Other specific agents that might increase exocrine pancreatic cancer risk include asbestos and ionizing radiations 3,10,12 .…”

Adipose tissue concentrations of persistent organic pollutants and total cancer risk in an adult cohort from Southern Spain: Preliminary data from year 9 of the follow-up

“…Diet, especially of animal origin, has been acknowledged as an important risk factor for cancer (Vieira et al, 2011) but is also responsible for most of the POP exposure in the general population (Agudo et al, 2009;Bosch de et al, 2010). We therefore assume that observed effects were mainly caused by the POPs present in the diet, and that the inclusion of diet as a covariate could produce an overadjustment of the models.…”

Exposición a carga física en el trabajo por ocupación: una explotación de los datos en matriz empleo-exposición española (MATEMESP)

“…Por tanto, una matriz empleo-exposición recopila información disponible de distintas fuentes y en distintos períodos y homogeneiza el uso de esa información reuniendo todos los datos a través de un eje común, la ocupación, facilitando así análisis simultáneos considerando distintos agentes de exposición y circunstancias asociadas a cada ocupación. En España se han llevado a cabo con cierta frecuencia estudios que han utilizado la información de matrices empleo-exposición elaboradas en otros paí-ses [2][3][4] , pero hasta el momento no se disponía de una MEE específica para población laboral española. El proyecto MatEmESp (Matriz Empleo-Exposición Española) se inició en 2009 con el objetivo de construir una matriz empleo exposición específica para población laboral española que cubriera el período 1996-2005.…”