Relationships between oral MUC1 expression and salivary hormones in burning mouth syndrome

Kang, Jeong‐Hyun; Kim, Yoon-Young; Chang, Ju Yong; Kho, Hong‐Seop

doi:10.1016/j.archoralbio.2017.01.022

Cited by 25 publications

(26 citation statements)

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“…A more recent study found that serum cortisol levels are slightly increased while dehydroepiandrosterone (DHEA), the precursor of testosterone and estradiol, is decreased significantly among patients who have BMS (das Neves de Araujo Lima et al 2016). Additional work examining salivary protein expression in the context of disease symptoms revealed that salivary 17β-estradiol levels correlated with disease severity (Kang et al 2017). Moreover, cortisol levels and the cortisol/DHEA ratio in whole saliva showed an inverse relationship with the severity of oral burning (Kang et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in the Etiology and Treatment of Burning Mouth Syndrome

Ritchie

Kramer

2018

J Dent Res

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Burning mouth syndrome (BMS) is a debilitating condition that has a striking female predilection. Although the oral mucosa is normal in appearance, patients with BMS experience oral burning that most commonly localizes to the lips and tongue. BMS is a diagnosis of exclusion, and all underlying pathoses associated with allodynia must be ruled out prior to rendering the diagnosis. The etiopathogenesis of BMS remains poorly understood, and thus patient management is challenging. Data indicate that oral and systemic factors both contribute to the development and persistence of the condition. Of particular interest, emerging work identifies structural and functional deficits within the nervous system that may lead to a more mechanistic understanding of BMS pathology. In addition, several novel findings suggest that circadian rhythm dysfunction may be a previously unappreciated yet clinically significant driver of disease. Circadian rhythm controls pain perception, mood, and sleep and plays a key role in the regulation of the hypothalamic-pituitary-adrenal axis. Since these are altered in patients with BMS, this may be reflective of underlying circadian dysfunction. While evidence-based treatment strategies for BMS are lacking, current treatment approaches consist of local and systemic medications, such as clonazepam, alpha lipoic acid, capsaicin, low-level laser therapy, gabapentin, and amitriptylin. In addition, the use of cognitive behavioral therapy is reported. This review provides an overview of the recent literature related to the etiology and treatment of BMS and identifies current challenges facing researchers and clinicians alike.

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Section: Introductionmentioning

confidence: 99%

Recent Advances in the Etiology and Treatment of Burning Mouth Syndrome

Ritchie

Kramer

2018

J Dent Res

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“…MUC1 expression levels in the oral mucosa were increased in patients with burning mouth syndrome compared with patients with oral lichen planus or normal controls (Kho et al., ). MUC1 expression levels in the oral mucosa in postmenopausal patients with burning mouth syndrome were also correlated with salivary levels of progesterone (Kang, Kim, Chang, & Kho, ). In addition, a positive relationship between the number of dental caries and MUC1 level in unstimulated whole saliva has been reported ( Gabryel‐Porowska et al., ).…”

Section: Oral Mucosal Epithelial Muc1 and Oral Diseasesmentioning

confidence: 99%

“…-Parotid gland/submandibular gland/sublingual gland/labial minor salivary gland/buccal epithelial cells (Offner & Troxler, 2000) -Membranes of the ductal cells in the minor salivary glands (Sengupta et al, 2001) -Epithelial cells lining striated and excretory ducts and some serous acinar cells in the parotid and submandibular glands (Liu et al, 2002) -Cultivated oral mucosal epithelial cells (Hori et al, 2007) Function -Protection of oral mucosal surfaces and salivary glands/Facilitation of salivary flow/Signal transduction and modulation of immune functions (Liu et al, 2002;Offner & Troxler, 2000;Sengupta et al, 2001) Modulation -Pro-inflammatory cytokines or Porphyromonas gingivalis (Li et al, 2003) -Age (Chang et al, 2011) -Salivary levels of cortisol, progesterone, and cortisol/dehydroepiandrosterone ratio (Lee et al, 2015) Associations with oral diseases -Dry mouth (Pramanik et al, 2010) -Burning mouth syndrome (Kang et al, 2017;Kho et al, 2013) -Dental caries (Gabryel-Porowska et al, 2014) T A B L E 1 MUC1 in the oral cavity | 21 KHO studies on the association of oral epithelial MUC1 with oral diseases are sparse. High MUC1 levels have been detected in the salivary layer coating oral mucosal surfaces of patients with dry mouth compared with normal salivators (Pramanik et al, 2010).…”

Section: Expressionmentioning

confidence: 99%

Oral epithelial MUC1 and oral health

Kho

2018

Oral Diseases

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“…Glycosylated transmembrane mucins, such as MUC1, are known as the second line of defense, possibly acting as sensors for any disturbance in the environment, signaling this information into the cell [20, 21], and interacting with local bacteria [22], acting as a barrier for opportunistic infections, against several bacterial strains. At this time, the microorganisms of the dental biofilm are disseminated into the systemic circulation, through the invasion of the gingival tissue throughout the ulcerated epithelium [23].…”

Section: Introductionmentioning

confidence: 99%

Hygiene protocols for the treatment of denture-related stomatitis: local and systemic parameters analysis - a randomized, double-blind trial protocol

Ribeiro

Araújo

Silva

et al. 2019

Trials

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BackgroundDenture-related stomatitis (DS) is chronic multifactorial inflammation, strongly related to the presence of the biofilm that is the complex structure formed by microorganisms held together by a mucus-like matrix of carbohydrate that adheres to different surfaces, including the denture surface. DS has recently been correlated with deleterious cardiovascular alterations. The potential effect of hygiene protocols in the control of DS and randomized clinical trials that address this oral condition with cardiovascular complications are important in clinical decision-making.Material/designA clinical trial, randomized, double-blind, and with parallel groups, will be conducted in Brazil The sample will consist of 100 patients without teeth in both arches, users of at least maxillary complete dentures, and diagnosed with DS, who will be allocated to groups (n = 25 per group) according to the different hygiene protocols: (1) brushing of the palate and immersion of the prosthesis in 0.25% sodium hypochlorite solution (positive control); (2) brushing of the palate and immersion of the prosthesis in 0.15% triclosan solution; (3) brushing of the palate and immersion of the prosthesis in lactose monohydrate; or (4) brushing the palate with citric acid and immersing the prosthesis in lactose monohydrate. The response variables will be heart rate variability and alteration of blood pressure (systemic level), remission of DS, removal of biofilm, reduction of microbial load (colony-forming units (CFU)), mouth and prosthesis odor level, expression of MUC1, proinflammatory cytokines, C-reactive protein (CRP), viscosity, pH and salivary flow (locally); patient-centred qualitative analysis will also be undertaken. Measurements will be performed at baseline and 10 days after the interventions. The results obtained will be statistically analyzed as pertinent, with a level of significance of 0.05.DiscussionThis study will provide a guideline for clinical practice regarding the use of hygiene protocols in the treatment of oral diseases (DS) mediated by biofilm. Also, it may provide evidence of correlation of oral manifestation with cardiac risk.Trial registrationBrazilian Registry of Clinical Trials, RBR-4hhwjb. Registered on 9 November 2018.

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Relationships between oral MUC1 expression and salivary hormones in burning mouth syndrome

Cited by 25 publications

References 50 publications

Recent Advances in the Etiology and Treatment of Burning Mouth Syndrome

Recent Advances in the Etiology and Treatment of Burning Mouth Syndrome

Oral epithelial MUC1 and oral health

Hygiene protocols for the treatment of denture-related stomatitis: local and systemic parameters analysis - a randomized, double-blind trial protocol

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