“…General medical problems secondary to alcohol consumption, acute and chronic toxicity of ethanol can affect the entire body [ 70 ]. The effects of alcohol on the brain are described below [ 71 , 72 , 73 ]: -
- under the influence of alcohol, emotions can become exaggerated and the consumer is excessively happy, expansive or emotional
- alcohol has a depressing effect on the central nervous system, causing drowsiness, an effect dependent on the amount consumed; over time alcohol changes the architecture of sleep, decreasing periods of deep sleep and increasing the number of awakenings during the night
- on a short-term, alcohol has an anxiolytic effect, but the period of relaxation and mental comfort is short
- influences the pleasure centers (dopamine-mediated) and the reward system in the brain, which partly explains the installation of alcohol dependence
- acts on the production of opioid substances, which explains the analgesic effect
- affects the hippocampus, the area of the brain where memory-related processes take place and so the consumer no longer remembers what he did during consumption and immediately afterwards
- inhibits the production of neurotransmitters, such as gamma-amino-butyric acid (GABA) and glutamate, the effect being to slow down the transmission of nerve impulses through the brain
- increased blood alcohol level over 0.05% causes disorders of nerve activity in the frontal lobe and thus difficulties in impulse control and decision making, decreased thought and judgment, reduced censorship
- the effect of alcohol on the cerebral amygdala causes consumers not to realize that certain actions of theirs can have dangerous effects and thus scandals, violence, accidents can occur
- the action of alcohol on the cerebellum leads to loss of balance, coordination of movements and instability of gait
- when the alcohol level exceeds 0.04%, the functioning of the reflex centers in the brainstem that control breathing, coughing, sneezing can be inhibited and they become unable to regulate the vital functions of the body, in extreme cases, death can occur[ 74 ].
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