Relationships Between Self-Injurious Behaviors, Pain Reactivity, and β-Endorphin in Children and Adolescents With Autism

Tordjman, Sylvie; Anderson, George M.; Charrier, Annaëlle; Oriol, Cécile; Kermarrec, Solenn; Canitano, Roberto; Botbol, Michel; Coulon, Nathalie; Antoine, Corinne; Brailly-Tabard, Sylvie; Cohen, David; Haidar, Hazar; Trabado, Séverine; Carlier, Michèle; Bronsard, Guillaume; Mottron, Laurent

doi:10.4088/jcp.16m10889

Cited by 15 publications

(17 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, this was questioned for decades. Nevertheless, nowadays it is well-accepted that individuals with autism do experience and express pain but in an atypical way (e.g., altered sensory thresholds, hypo- and hyper-responsiveness including behavioral problems) (2, 9, 10).…”

Section: Introductionmentioning

confidence: 99%

Autism, Joint Hypermobility-Related Disorders and Pain

et al. 2018

Self Cite

View full text Add to dashboard Cite

Autism Spectrum Disorder (ASD) and Joint Hypermobility-Related Disorders are blanket terms for two etiologically and clinically heterogeneous groups of pathologies that usually appears in childhood. These conditions are seen by different medical fields, such as psychiatry in the case of ASD, and musculoskeletal disciplines and genetics in the case of hypermobility-related disorders. Thus, a link between them is rarely established in clinical setting, despite a scarce but growing body of research suggesting that both conditions co-occur more often than expected by chance. Hypermobility is a frequent sign of hereditary disorders of connective tissue (e.g., Ehlers-Danlos syndromes, Marfan syndrome), in which the main characteristic is the multisystem fragility that prone to proprioceptive and motor coordination dysfunction and hence to trauma and chronic pain. Considering the high probability that pain remains disregarded and untreated in people with ASD due to communication and methodological difficulties, increasing awareness about the interconnection between ASD and hypermobility-related disorders is relevant, since it may help identify those ASD patients susceptible to chronic pain.

show abstract

Section: Introductionmentioning

confidence: 99%

Autism, Joint Hypermobility-Related Disorders and Pain

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…On the other hand, concerning pain experience and self‐injury in patients with intellectual disability (ID), reduced pain reactivity has been recently described in autism (Tordjman et al, ) and in Smith–Magenis syndrome (Poisson et al, ). Increased thermic tolerance and threshold have been reported even in patients with Prader–Willi syndrome (Priano et al, ).…”

Section: Discussionmentioning

confidence: 99%

Skin picking disorder in 97 Italian and Spanish Cri du chat patients

Spunton

Guala

Liverani

et al. 2019

American J of Med Genetics Pt A

View full text Add to dashboard Cite

Skin picking (SP) disorder is characterized by recurrent SP resulting in skin lesions.Several studies estimated its prevalence as approximately 2-4 % of the general population. It is also present in a high percentage of patients with intellectual and developmental disabilities, such as Cri du chat (CdC) syndrome, a rare genetic disorder caused by variable size deletions of the short arm of chromosome 5. The aim of this study was to evaluate, in 97 patients with CdC syndrome, the following data: frequency of SP, patient's age at onset, type, and topographic-anatomic distribution of the lesions presented. The results show that 85% of patients confirm a SP disorder, usually concentrated on the hands, fingers, and the face, with onset between 6 and 10 years of age, regardless of patient's sex. Evidence for early appearance of SP behavior, high prevalence in stressful circumstances, and efficacy of distracting actions immediately suggest the possibility that proper parental information about SP behavior and parental education concerning the methods to deal with this problem may result in its efficient reduction already in childhood.

show abstract

“…Nociceptive (pain) processing is commonly disturbed in ASD according to self-report, questionnaire, observational, and neuroimaging studies [25,81,104,105,106,107]. Self-report, observational, and neuroimaging evidence support commonly impaired sensitivity to conditions of heat and cold in ASD [30,53,58,65,108,109].…”

Section: Major Symptoms and Features Of Asdmentioning

confidence: 99%

“…A diverse set of behavioral abnormalities is collected together into the domain of restricted repetitive patterns of behavior, interests, or activities [58]. Examples are pacing and stereotyped walking; rocking of the body; inflexible rituals that are integral to washing, dressing, and other regular activities; insistence on sameness and intolerance of even trivial changes to environment, routines, or rituals; circumscribed interests as described earlier; and SIBs such as hand biting or head banging [58,107,157,158]. Models involving two or three subtypes of repetitive behaviors have been generated [158,159,160], and in support of these developmental patterns, and associations with ASD and patient variables, differ across subtypes [158,159]; such models have value but also limitations.…”

Section: Major Symptoms and Features Of Asdmentioning

confidence: 99%

Four Social Brain Regions, Their Dysfunctions, and Sequelae, Extensively Explain Autism Spectrum Disorder Symptomatology

Weston¹

2019

Brain Sciences

View full text Add to dashboard Cite

Autism spectrum disorder (ASD) is a challenging neurodevelopmental disorder with symptoms in social, language, sensory, motor, cognitive, emotional, repetitive behavior, and self-sufficient living domains. The important research question examined is the elucidation of the pathogenic neurocircuitry that underlies ASD symptomatology in all its richness and heterogeneity. The presented model builds on earlier social brain research, and hypothesizes that four social brain regions largely drive ASD symptomatology: amygdala, orbitofrontal cortex (OFC), temporoparietal cortex (TPC), and insula. The amygdala’s contributions to ASD largely derive from its major involvement in fine-grained intangible knowledge representations and high-level guidance of gaze. In addition, disrupted brain regions can drive disturbance of strongly interconnected brain regions to produce further symptoms. These and related effects are proposed to underlie abnormalities of the visual cortex, inferior frontal gyrus (IFG), caudate nucleus, and hippocampus as well as associated symptoms. The model is supported by neuroimaging, neuropsychological, neuroanatomical, cellular, physiological, and behavioral evidence. Collectively, the model proposes a novel, parsimonious, and empirically testable account of the pathogenic neurocircuitry of ASD, an extensive account of its symptomatology, a novel physiological biomarker with potential for earlier diagnosis, and novel experiments to further elucidate the mechanisms of brain abnormalities and symptomatology in ASD.

show abstract

Relationships Between Self-Injurious Behaviors, Pain Reactivity, and β-Endorphin in Children and Adolescents With Autism

Cited by 15 publications

References 0 publications

Autism, Joint Hypermobility-Related Disorders and Pain

Autism, Joint Hypermobility-Related Disorders and Pain

Skin picking disorder in 97 Italian and Spanish Cri du chat patients

Four Social Brain Regions, Their Dysfunctions, and Sequelae, Extensively Explain Autism Spectrum Disorder Symptomatology

Contact Info

Product

Resources

About