Relationships between serum brain-derived neurotrophic factor, plasma catecholamine metabolites, cytokines, cognitive function and clinical symptoms in Japanese patients with chronic schizophrenia treated with atypical antipsychotic monotherapy

Hori, Hikaru; Yoshimura, Reiji; Katsuki, Asuka; Atake, Kiyokazu; Igata, Ryohei; Konishi, Yuki; Nakamura, Jun

doi:10.1080/15622975.2016.1212172

Cited by 35 publications

(27 citation statements)

References 42 publications

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“…In this study, an increased TNF-α level was determined in the patient group, but this difference could not reach statistical significance. Similar to the present study, Hori et al [41] assessed TNF-α levels in clinically stable patients with schizophrenia, and they found no difference compared to healthy controls. There are controversial findings regarding TNF-α levels in patients with schizophrenia [35,42].…”

Section: Discussionsupporting

confidence: 86%

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The relationship between psychopathology and cognitive functions with cytokines in clinically stable patients with schizophrenia

Ergün

Yanartaş

Kandemir

et al. 2017

Psychiatry and Clinical Psychopharmacology

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OBJECTIVES: Inflammation and the cytokine hypotheses have been proposed for schizophrenia. Several proinflammatory and anti-inflammatory cytokines have been studied in drug-naive, first-episode, and/or chronic schizophrenia patients. However, there were limited data on clinical stable outpatients reflecting daily routine. The aim of this study was to compare the serum levels of cytokines, including transforming growth factor-beta (TGF-β), interleukin-6 (IL-6), and tumour necrosis factor-alpha (TNF-α), between clinically stable patients with schizophrenia and healthy controls, as well as to examine the relationship between these inflammation parameters and clinical variables (positive and negative symptom severity and cognitive functions). METHODS: Thirty clinically stable outpatients with schizophrenia and 30 healthy controls with similar sex and age were included in this study. Serum IL-6, TGF-β, and TNF-α levels were assessed by enzyme-linked immunosorbent assay (ELISA) and immunoenzyme microplate measurement, respectively. Illness severity was evaluated using the Positive and Negative Syndrome Scale (PANSS), and the cognitive functions of the participants were assessed using a broad neuropsychological test battery. RESULTS: The serum levels of IL-6 and TGF-β were significantly higher in patients with schizophrenia compared to healthy controls (p = .048, p = .012). There was no significant difference between groups in terms of TNF-α levels (p = .726). Global impairment of cognitive functions was observed in the patient group compared to healthy controls, and PANSS scores and cognitive functions showed no correlation with cytokine levels (IL-6, TNF-α, and TGF-β). CONCLUSIONS: The present study demonstrated an increased inflammatory response in clinically stable patients with schizophrenia compared to healthy controls. However, symptom severity and cognitive functions showed no correlation with cytokine levels. Further research studies are needed to clarify the effects of cytokine levels on schizophrenia symptomatology and etiopathogenesis.

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Section: Discussionsupporting

confidence: 86%

“…In the two studies looking for the correlation of cytokine levels with PANSS scores and cognitive functions in clinically stable schizophrenia patients; the first assessed TGF-β, while the other evaluated IL-6 and TNF-α levels. Both studies showed no correlation of cytokine levels with PANSS scores and cognitive functions [40,41].…”

Section: Discussionmentioning

confidence: 99%

The relationship between psychopathology and cognitive functions with cytokines in clinically stable patients with schizophrenia

Ergün

Yanartaş

Kandemir

et al. 2017

Psychiatry and Clinical Psychopharmacology

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“…We also observed that plasma MHPG levels were associated with cognitive domains such as verbal learning, working memory, verbal fluency, attention and processing speed, and executive function, suggesting that preserved cognitive functioning in patients receiving aripiprazole may be partly related to activation of the noradrenergic system activation. Indeed, a previous study [22] reported that the plasma MHPG level was associated with attention and processing speed, and that eight weeks of aripiprazole treatment significantly increased plasma MHPG levels.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies of schizophrenia have noted that the behavioral response to antipsychotic drugs, such as a decrease in psychosis, parallels a decrease in plasma HVA levels in schizophrenic patients over time [10,11,12,13,14,15,16,17,18,19,20]. Atypical antipsychotics increase the plasma 3-methoxy-4-hydroxyphenylglycol (MHPG) levels and are associated with negative symptoms and cognitive functions [19,21,22]. Brain-derived neurotrophic factor (BDNF) is the most widely distributed neurotrophic factor in the brain, the levels of which have been associated with schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

Blood Biomarkers Predict the Cognitive Effects of Aripiprazole in Patients with Acute Schizophrenia

Hori

Yoshimura

Katsuki

et al. 2017

IJMS

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Aripiprazole has been reported to exert variable effects on cognitive function in patients with schizophrenia. Therefore, in the present study, we evaluated biological markers, clinical data, and psychiatric symptoms in order to identify factors that influence cognitive function in patients with schizophrenia undergoing aripiprazole treatment. We evaluated cognitive function in 51 patients with schizophrenia using Brief Assessment of Cognition in Schizophrenia (BACS), as well as background information, psychiatric symptoms, plasma catecholamine metabolites—homovanillic acid (HVA), 3-methoxy-4-hydroxyphenylglycol (MHPG)—, and serum brain-derived neurotrophic factor (BDNF). Multivariate analyses were performed in order to identify factors independently associated with cognitive function. Brain-derived neurotrophic factor levels, number of hospitalizations, and MHPG levels were associated with verbal memory and learning. Total hospitalization period and MHPG levels were associated with working memory. Age at first hospitalization and education were associated with motor speed. The number of hospital admissions, Positive and Negative Syndrome Scale negative subscale scores (PANSS-N), MHPG levels, BDNF levels, and Drug-Induced Extrapyramidal Symptoms Scale (DIEPSS) scores were associated with verbal fluency. Homovanillic acid and MHPG levels, duration of illness, and PANSS-N scores were associated with attention and processing speed. Brain-derived neurotrophic factor and MHPG levels were associated with executive function. These results suggest that treatment of psychiatric symptoms and cognitive dysfunction may be improved in patients treated with aripiprazole by controlling for these contributing factors.

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“…Several studies of schizophrenia have noted that the behavioral response to antipsychotic drugs, such as a decrease in psychosis, parallels a decrease in plasma HVA levels in schizophrenic patients over time [10][11][12][13][14][15][16][17][18][19][20]. Atypical antipsychotics increase the plasma 3-methoxy-4-hydroxyphenylglycol (MHPG) levels and are associated with negative symptoms and cognitive functions [19,21,22]. Brain-derived neurotrophic factor (BDNF) is the most widely distributed neurotrophic factor in the brain, the levels of which have been associated with schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

Blood biomarkers predict the cognitive effects of aripiprazole in patients with acute schizophrenia

Hori

Yoshimura

Katsuki

et al. 2017

European Neuropsychopharmacology

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Relationships between serum brain-derived neurotrophic factor, plasma catecholamine metabolites, cytokines, cognitive function and clinical symptoms in Japanese patients with chronic schizophrenia treated with atypical antipsychotic monotherapy

Abstract: Serum BDNF levels are positively related to the impairment of verbal memory and attention, plasma HVA levels are positively related to motor function, and plasma MHPG levels are positively related to attention in patients with schizophrenia.

Cited by 35 publications

References 42 publications

The relationship between psychopathology and cognitive functions with cytokines in clinically stable patients with schizophrenia

The relationship between psychopathology and cognitive functions with cytokines in clinically stable patients with schizophrenia

Blood Biomarkers Predict the Cognitive Effects of Aripiprazole in Patients with Acute Schizophrenia

Blood biomarkers predict the cognitive effects of aripiprazole in patients with acute schizophrenia

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