Relationships between serum levels of thyroid hormones and serum concentrations of asymmetric dimethylarginine (ADMA) and N-terminal-pro-B-type natriuretic peptide (NT-proBNP) in patients with Graves’ disease

Gu, Li-Qun; Zhao, Lin; Zhu, Wei; Li, Fengying; Zhang, Minjia; Liu, Yun; Liu, Jianmin; Ning, Guang; Zhao, Yong

doi:10.1007/s12020-011-9436-7

Cited by 26 publications

(17 citation statements)

References 36 publications

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“…Mean ADMA level was the highest among the hyperthyroid group. Gu et al showed that ADMA increases in patients with Graves (15). The result of the present study was in concordance with the results of the all of the aforementioned studies.…”

Section: Discussionsupporting

confidence: 93%

Asymmetric Dimethyl Arginine Level as a Cardiovascular Risk Factor in Patients with Hyperthyroidism

Alçelik¹

2012

Acta Endo (Buc)

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Introduction. Thyroid diseases may cause endothelial dysfunction. Asymmetric dimethylarginine (ADMA) levels in patients with thyroid dysfunction were analyzed by few studies.Aim.We aimed to compare ADMA levels in patients with hyperthyroidism in a cohort free of cardiovascular risk associates such as diabetes or chronic renal failure with further comparison with healthy control subjects.Materials and methods. The study took place in Duzce University Medical Faculty, Cardiology and Internal Medicine Department during the year 2010. The study group consisted of patients with hyperthyroidism (overt and subclinical). The patients with renal failure, diabetes and severe hypertension were excluded.Results. Mean ADMA level was 1.04 ± 0.43 µmol/L in the hyperthyroid group and 0.68 ± 0.21 µmol/L in the control group (p≤0.001). The comparison of patients with hyperthyroidism according to the etiology (three groups as Graves', multinodular goiter and thyroiditis) did not show any significant difference.Conclusion. Asymmetric dimethylarginine increases in patients with hyperthyroidism regardless of the etiology. The increase of ADMA levels is independent of known major cardiovascular risk factors. It may reflect the possible counteraction of endothelial dysfunction in the pathogenesis of atherosclerosis in hyperthyroidism beyond the known cardiovascular risk factors.

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Section: Discussionsupporting

confidence: 93%

Asymmetric Dimethyl Arginine Level as a Cardiovascular Risk Factor in Patients with Hyperthyroidism

Alçelik¹

2012

Acta Endo (Buc)

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“…However, it must be stated that this study lacked a control group [34]. The positive association of increased NT-pro-BNP, as well as asymmetric dimethylarginine (a marker of endothelial dysfunction), with free thyroid hormone levels and heart rate has also been confirmed by others [35]. Another study has been conducted in patients with GD and overt hyperthyroidism in which AS was estimated as pulse pressure (that is systolic-diastolic BP)/stroke volume, by using echocardiographic methodology.…”

Section: Hyperthyroidism and Arterial Stiff-nesssupporting

confidence: 51%

Thyroid Dysfunction and Arterial Stiffness. Does the Restoration of Thyroid Function Tests Offer any Benefit?

Anagnostis¹,

Karras²,

Gotsis³

et al. 2013

TOHYPERJ

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A growing body of evidence suggests that hypothyroidism and hyperthyroidism, either as overt or subclinical states, are associated with increased risk for cardiovascular disease (CVD). Except for the increased prevalence of lipid disorders, coagulation abnormalities, endothelial dysfunction, cardiac arrhythmias, ventricular hypertrophy and hypertension have been proposed as the most plausible pathways for this association, increased arterial stiffness (AS) may also play a role. Increased AS has emerged recently as an early indicator of CVD in various studies. On the other hand, thyroid dysfunction, mainly hypothyroidism (overt and subclinical) seems to be associated with increased AS, although data are heterogeneous, emerging from different populations, with various methodologies of AS assessment and with variable periods of observation. Restoration of thyroid function with L-thyroxin replacement seems to reverse AS parameters, whereas data on the effect of normalization of thyroid function in hyperthyroidism on AS are inconsistent. The present review provides insights on the association between AS and thyroid dysfunction and discusses the available data about potential benefits of the restoration of thyroid function on AS.

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“…The plasma concentration of these methylarginines in renal transplant patients correlates inversely with the renal expression of alanine-glyoxylate aminotransferase 2 (26). ADMA is substantially raised in hyperthyroidism (27) and critical illness (28), that is, two conditions characterized by high sympathetic activity (29,30) and enhanced protein degradation (31,32), suggesting that reduced sympathetic activity after renal denervation may attenuate the release of these compounds from methylated proteins. Whether the sympathetic system regulates methylarginines by interfering with the synthesis or the degradation of these compounds remains to be investigated in future studies.…”

Section: Discussionmentioning

confidence: 99%

Asymmetric and Symmetric Dimethylarginine and Sympathetic Nerve Traffic after Renal Denervation in Patients with Resistant Hypertension

Seravalle

Trevano

Spaziani³

et al. 2015

Clinical Journal of the American Society of Nephrology

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Background and objectives The plasma concentration of the endogenous inhibitor of nitric oxide synthase asymmetric dimethylarginine (ADMA) associates with sympathetic activity in patients with CKD, but the driver of this association is unknown.Design, setting, participants, & measurements In this longitudinal study (follow-up: 2 weeks-6 months), repeated measurements over time of muscle sympathetic nerve activity corrected (MSNAC), plasma levels of ADMA and symmetric dimethylarginine (SDMA), and BP and heart rate were performed in 14 patients with drug-resistant hypertension who underwent bilateral renal denervation (enrolled in 2013 and followed-up until February 2014). Stability of ADMA, SDMA, BP, and MSNAC over time (6 months) was assessed in two historical control groups of patients maintained on stable antihypertensive treatment.Results Time-integrated changes in MSNAC after renal denervation ranged from -40.6% to 10% (average, -15.1%), and these changes were strongly associated with the corresponding changes in plasma ADMA (r= 0.62, P=0.02) and SDMA (r=0.72, P=0.004). Changes in MSNAC went along with simultaneous changes in standardized systolic (r=0.65, P=0.01) and diastolic BP (r=0.61, P=0.02). In the historical control groups, no change in ADMA, SDMA, BP, and MSNAC levels was recorded during a 6-month follow-up. ConclusionsIn patients with resistant hypertension, changes in sympathetic activity after renal denervation associate with simultaneous changes in plasma levels of the two major endogenous methylarginines, ADMA and SDMA. These observations are compatible with the hypothesis that the sympathetic nervous system exerts an important role in modulating circulating levels of ADMA and SDMA in this condition.

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Relationships between serum levels of thyroid hormones and serum concentrations of asymmetric dimethylarginine (ADMA) and N-terminal-pro-B-type natriuretic peptide (NT-proBNP) in patients with Graves’ disease

Cited by 26 publications

References 36 publications

Asymmetric Dimethyl Arginine Level as a Cardiovascular Risk Factor in Patients with Hyperthyroidism

Asymmetric Dimethyl Arginine Level as a Cardiovascular Risk Factor in Patients with Hyperthyroidism

Thyroid Dysfunction and Arterial Stiffness. Does the Restoration of Thyroid Function Tests Offer any Benefit?

Asymmetric and Symmetric Dimethylarginine and Sympathetic Nerve Traffic after Renal Denervation in Patients with Resistant Hypertension

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