Relationships between serum selenium and zinc concentrations versus profibrotic and proangiogenic cytokines (FGF-19 and endoglin) in patients with alcoholic liver cirrhosis

Abstract

Relationships between serum selenium and zinc concentrations versus profibrotic and proangiogenic cytokines in patients with alcoholic liver cirrhosis. Ann Agric Env Med. 2017; 24(3): 544-548. doi: 10.26444/aaem/76937 Abstract Introduction and objective. Liver cirrhosis is a disease involving the liver parenchyma, which is characterised by fibrosis. and impaired architectonics of the parenchyma with regenerative nodules. The aim of the study was to determine the relationship between stage of alcoholic liver cirrhosis, concentrations of selenium, zinc and profibrotic and proangiogenic cytokines ENG). Materials and method. The study included 99 patients with alcoholic cirrhosis and 20 healthy subjects. Ion chromatography with UV/VIS detection was used for determination of zinc ions in the previously mineralized serum samples. The measurements of selenium were performed with the ContrAA700 high-resolution continuum source graphite tube atomic absorption spectrometer. ELISA was used to determine concentration of FGF-19 and ENG in serum samples. Results. Concentrations of zinc and selenium were significantly decreased in cirrhotic patients (p<0.001 for both). The highest concentration of FGF-19 was found in Child-Pugh stage C liver cirrhosis patients (806.9±650.3 pg/ml), and was significantly higher than observed in controls (p=0.005) and stage A patients (compensated cirrhosis) (p=0.02). The highest concentration of ENG was demonstrated in the control group (3.24±148 ng/ml) while the lowest in patients with decompensated cirrhosis (7.32±5.39 ng/ml and 7.92±4.18 ng/ml for stage B and C; p=0.03 and p=0.02, respectively). The use of the multiple-variable model demonstrated that the independent factors affecting the concentration of ENG were the concentration of bilirubin (p=0.02), INR (p=0.01) and duration of alcohol abuse (p=0.02). The independent determinants of FGF-19 concentrations were found to be the stage (severity) of liver cirrhosis (p=0.04) and INR (p=0.03). Conclusions. Concentrations of zinc and selenium in serum of patients with alcoholic liver cirrhosis are not independently related to concentrations of FGF-19 and ENG.

The role of vitamin and microelement supplementation in the treatment of ethanol-induced liver disease

“…Selenium deficiency is often seen in ALD [ 41 ]. It has been shown that the level of selenium is lower in the group of patients with alcoholic liver cirrhosis compared to healthy ones, and it decreases proportionally with the degree of liver fibrosis [ 42 ]. The lowest concentration of serum selenium among liver diseases is found in HCC [ 18 ].…”

Current understanding of the metabolism of micronutrients in chronic alcoholic liver disease

“…Selenium is an important component of antioxidant-glutathione peroxidase and thus it has been broadly used in the clinic due to its antioxidant property. Abnormal metabolism of selenium has been reported in a growing body of research, which suggested that low selenium level is a common feature of patients with ALD[ 52 ]. Selenium metabolic disorder may lead to liver dysfunction[ 52 , 53 ].…”

“…Abnormal metabolism of selenium has been reported in a growing body of research, which suggested that low selenium level is a common feature of patients with ALD[ 52 ]. Selenium metabolic disorder may lead to liver dysfunction[ 52 , 53 ]. However, the involvement of selenium depletion in the pathogenesis of ALD has not been fully defined.…”

Role of Endoglin (CD105) in the Progression of Hepatocellular Carcinoma and Anti-Angiogenic Therapy

“…In contrast to these results, the study of Prystupa et al showed the lowest concentration of Sol-ENG in patients with decompensated alcoholic liver cirrhosis and the highest in the control group. Moreover, their study demonstrated that the independent factors affecting the Sol-ENG level were the concentration of bilirubin, INR, and duration of alcohol abuse [123].…”