Relationships Between Skeletal Muscle Mass, Lumbar Lordosis, and Chronic Low Back Pain in the Elderly

Park, Myung Woo; Park, Sang Jun; Chung, Sun Gun

doi:10.14245/ns.2346494.247

Cited by 7 publications

(3 citation statements)

References 41 publications

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“…In various LBP animal models, Wang et al (2021) also found lower abundance of Lachnospiraceae NK4A136 group in rats with lumbar disk herniation compared to the control group. A cross-sectional study revealed a significant reduction in skeletal muscle mass index in patients with LBP compared to normal individuals ( Park et al, 2023 ). Sugimura et al (2022) found a positive relationship between the abundance of Eisenbergiella and skeletal muscle mass, suggesting a reasonable hypothesis that Eisenbergiella may prevent LBP by increasing lumbar skeletal muscle mass.…”

Section: Discussionmentioning

confidence: 99%

Genetically predicted causal effects of gut microbiota on spinal pain: a two-sample Mendelian randomization analysis

Hong,

Chen,

Zhou

et al. 2024

Front. Microbiol.

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BackgroundObservational studies have hinted at a correlation between the gut microbiota and spinal pain (SP). However, the impact of the gut microbiota on SP remains inconclusive.MethodsIn this study, we employed a two-sample Mendelian randomization (MR) analysis to explore the causal relationship between the gut microbiota and SP, encompassing neck pain (NP), thoracic spine pain (TSP), low back pain (LBP), and back pain (BP). The compiled gut microbiota data originated from a genome-wide association study (GWAS) conducted by the MiBioGen consortium (n = 18,340). Summary data for NP were sourced from the UK Biobank, TSP from the FinnGen Biobank, and LBP from both the UK Biobank and FinnGen Biobank. Summary data for BP were obtained from the UK Biobank. The primary analytical approach for assessing causal relationships was the Inverse Variance Weighted (IVW) method, supplemented by various sensitivity analyses to ensure result robustness.ResultsThe IVW analysis unveiled 37 bacterial genera with a potential causal relationship to SP. After Benjamini-Hochberg corrected test, four bacterial genera emerged with a strong causal relationship to SP. Specifically, Oxalobacter (OR: 1.143, 95% CI 1.061–1.232, P = 0.0004) and Tyzzerella 3 (OR: 1.145, 95% CI 1.059–1.238, P = 0.0007) were identified as risk factors for LBP, while Ruminococcaceae UCG011 (OR: 0.859, 95% CI 0.791–0.932, P = 0.0003) was marked as a protective factor for LBP, and Olsenella (OR: 0.893, 95% CI 0.839–0.951, P = 0.0004) was recognized as a protective factor for low back pain or/and sciatica. No significant heterogeneity or horizontal pleiotropy was observed through alternative testing methods.ConclusionThis study establishes a causal relationship between the gut microbiota and SP, shedding light on the “gut-spine” axis. These findings offer novel perspectives for understanding the etiology of SP and provide a theoretical foundation for potential interventions targeting the gut microbiota to prevent and treat SP.

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Section: Discussionmentioning

confidence: 99%

Genetically predicted causal effects of gut microbiota on spinal pain: a two-sample Mendelian randomization analysis

Hong,

Chen,

Zhou

et al. 2024

Front. Microbiol.

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“…Despite the widespread prevalence of cervical muscle degeneration, it has not garnered commensurate attention relative to the lumbar spine ( 40 – 44 ). He et al.…”

Section: Discussionmentioning

confidence: 99%

“…Despite the widespread prevalence of cervical muscle degeneration, it has not garnered commensurate attention relative to the lumbar spine (40)(41)(42)(43)(44). He et al observed a degeneration rate of 69.1% in the paraspinal muscles (Goutallier Grade ≥1.5) among patients with two-level cervical disc degenerative disease (24).…”

Section: Discussionmentioning

confidence: 99%

Comparison of the effectiveness of zero-profile device and plate cage construct in the treatment of one-level cervical disc degenerative disease combined with moderate to severe paraspinal muscle degeneration

Abudouaini,

Xu,

Yang

et al. 2023

Front. Endocrinol.

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ObjectiveRecent evidence indicates that cervical paraspinal muscle degeneration (PMD) is a prevalent and age-related condition in patients with cervical disc degenerative disease (CDDD). However, the relationship between surgery selection and post-operative outcomes in this population remains unclear. Consequently, this study aims to investigate the disparities in clinical outcomes, radiological findings, and complications between two frequently utilized anterior cervical surgical procedures. The objective is to offer guidance for the management of PMD in conjunction with CDDD.MethodsA total of 140 patients who underwent single-level anterior cervical discectomy and fusion (ACDF) at our department were included in this study. The patients were divided into three groups based on the severity of PMD: mild (n=40), moderate (n=54), and severe (n=46), as determined by Goutalier fat infiltration grade. The subjects of interest were those with moderate-severe PMD, and their clinical outcomes, radiological parameters, and complications were compared between those who received a stand-alone zero-profile anchored cage (PREVAIL) and those who received a plate-cage construct (PCC).ResultsThe JOA, NDI, and VAS scores exhibited significant improvement at all postoperative intervals when compared to baseline, and there were no discernible differences in clinical outcomes between the two groups. While the PCC group demonstrated more pronounced enhancements and maintenance of several sagittal alignment parameters, such as the C2-7 angle, FSU angle, C2-7 SVA, and T1 slope, there were no statistically significant differences between the two groups. The incidence of dysphagia in the zero-profile group was 22.41% at one week, which subsequently decreased to 13.79% at three months and 3.45% at the final follow-up. In contrast, the plate cage group exhibited a higher incidence of dysphagia, with rates of 47.62% at one week, 33.33% at three months, and 11.90% at the final follow-up. Notably, there were significant differences in the incidence of dysphagia between the two groups within the first three months. However, the fusion rate, occurrence of implant subsidence, and adjacent segment degeneration (ASD) were comparable at the final follow-up.ConclusionFor patients with one-level cervical disc degenerative disease combined with paraspinal muscle degeneration, both the zero-profile technique and PCC have demonstrated efficacy in ameliorating clinical symptoms and maintaining the postoperative sagittal balance. Although no significant disparities were observed between these two technologies in terms of complications such as adjacent segment degeneration and implant subsidence, the zero-profile technique exhibited superior performance over PCC in relation to dysphagia during the early stages of postoperative recovery. To validate these findings, studies with longer follow-up periods and evaluations of multilevel cervical muscles are warranted.

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Causal associations between sarcopenia-related traits and intervertebral disc degeneration: a two-sample mendelian randomization analysis

Qi,

Mei,

Mao

et al. 2024

Eur Spine J

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Relationships Between Skeletal Muscle Mass, Lumbar Lordosis, and Chronic Low Back Pain in the Elderly

Cited by 7 publications

References 41 publications

Genetically predicted causal effects of gut microbiota on spinal pain: a two-sample Mendelian randomization analysis

Genetically predicted causal effects of gut microbiota on spinal pain: a two-sample Mendelian randomization analysis

Comparison of the effectiveness of zero-profile device and plate cage construct in the treatment of one-level cervical disc degenerative disease combined with moderate to severe paraspinal muscle degeneration

Causal associations between sarcopenia-related traits and intervertebral disc degeneration: a two-sample mendelian randomization analysis

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